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Apigenin

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Identification
Molecular formula
C15H10O5
CAS number
520-36-5
IUPAC name
4,5-dihydroxy-2-phenyl-chromen-7-one
State
State

At room temperature, apigenin is a solid. It forms bright yellow crystals, indicative of its flavone nature. This solid state is typical for many naturally occurring polyphenolic compounds.

Melting point (Celsius)
345.00
Melting point (Kelvin)
618.00
Boiling point (Celsius)
553.00
Boiling point (Kelvin)
826.00
General information
Molecular weight
270.24g/mol
Molar mass
270.2400g/mol
Density
1.5866g/cm3
Appearence

Apigenin typically appears as a yellow crystalline solid. It is known for its distinct, vibrant yellow color, which is typical of flavones due to the presence of conjugated systems within their molecular structure. It is poorly soluble in water at room temperature but can dissolve in organic solvents such as ethanol and DMSO.

Comment on solubility

Solubility of 4,5-dihydroxy-2-phenyl-chromen-7-one

The solubility of 4,5-dihydroxy-2-phenyl-chromen-7-one (C15H10O5), often referred to as a flavonoid compound, presents certain interesting characteristics:

  • Polar character: Due to the presence of hydroxyl (-OH) groups, this compound exhibits a degree of polarity, which typically enhances solubility in polar solvents such as water.
  • Solvent Interaction: It is frequently soluble in organic solvents like ethanol and methanol, where it can participate in hydrogen bonding due to its hydroxyl groups.
  • Influence of pH: The solubility may vary with pH; at lower pH values, the compound may remain more soluble due to protonation effects.
  • Temperature Dependency: Like many organic compounds, the solubility can be affected by temperature, with higher temperatures often leading to increased solubility.

In summary, while 4,5-dihydroxy-2-phenyl-chromen-7-one shows notable solubility characteristics, it is essential to consider both the solvent and environmental conditions when determining its solubility profile in various applications.

Interesting facts

Interesting Facts About 4,5-Dihydroxy-2-phenyl-chromen-7-one

4,5-Dihydroxy-2-phenyl-chromen-7-one, commonly known for its role in the **flavonoid** family, holds a wealth of intriguing characteristics that beckon the attention of scientists and students alike. This compound is primarily noted for its diverse biological activities, making it a subject of extensive research in various fields, from pharmacology to natural product chemistry.

Key Features

  • Biological Activity: Compounds like 4,5-dihydroxy-2-phenyl-chromen-7-one are celebrated for their antioxidant properties, which help combat oxidative stress in cells.
  • Pharmacological Potential: Research has shown that this flavonoid exhibits anti-inflammatory and anticancer effects, fostering interest in its medicinal applications.
  • Natural Sources: This compound is often isolated from a variety of plants, particularly those used in traditional herbal medicine, underscoring its significance in natural product research.
  • Chemical Reactivity: Due to its hydroxyl groups (-OH), this compound is particularly reactive, enabling various chemical modifications that can enhance its therapeutic profile.

Furthermore, its structure, featuring the characteristic chromenone scaffold, allows for interactions with biological macromolecules, making it an excellent candidate for drug design. As scientists continue to explore its pathways and effects, 4,5-dihydroxy-2-phenyl-chromen-7-one stands as a prime example of how organic compounds can bridge the gap between chemistry and health, opening avenues for innovative treatment strategies.

As the motto in chemistry goes, "To understand the properties of matter is to understand the universe," and compounds like this one are fundamental to that understanding. Whether as part of a research study or a discussion in a classroom setting, the exploration of this flavonoid is bound to spark curiosity and inspire future discoveries.