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Bortezomib

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Identification
Molecular formula
C19H25BBr2N4O4
CAS number
179324-69-7
IUPAC name
[4,4-dibromo-1-[[1-[2-(5-oxopentanoylamino)-3-phenyl-propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid
State
State

At room temperature, Bortezomib is typically in a solid state.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
360.15
Boiling point (Kelvin)
633.30
General information
Molecular weight
384.19g/mol
Molar mass
384.1910g/mol
Density
1.8830g/cm3
Appearence

Bortezomib typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4,4-Dibromo-1-[[1-[2-(5-oxopentanoylamino)-3-phenyl-propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid (C19H25BBr2N4O4)

The solubility of the compound 4,4-dibromo-1-[[1-[2-(5-oxopentanoylamino)-3-phenyl-propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid can be influenced by various factors related to its chemical structure. Key points to consider include:

  • Polarity: The presence of multiple functional groups such as amides and carboxylic acids suggests that the compound may have varying degrees of polarity, potentially increasing its solubility in polar solvents.
  • Hydrogen bonding: The ability to form hydrogen bonds can significantly enhance solubility in aqueous environments, which may apply to this compound due to its amine and carbonyl groups.
  • Hydrophobic regions: The hydrophobic phenyl and alkyl sectors of the compound can impair solubility in water, suggesting that it may be more readily soluble in organic solvents.

In practical terms, it is crucial to consider how the compound behaves in different solvents:

  • Aqueous solutions: May exhibit limited solubility due to hydrophobic characteristics.
  • Organic solvents: Likely to show better solubility; solvents such as dimethyl sulfoxide (DMSO) or acetonitrile could be beneficial for dissolving this compound.

Overall, the solubility of C19H25BBr2N4O4 presents a complex profile that may require empirical testing to characterize thoroughly in various solvent environments. As a final note, the influence of temperature and pH on solubility should not be underestimated.

Interesting facts

Interesting Facts About 4,4-Dibromo-1-[[1-[2-(5-Oxopentanoylamino)-3-phenyl-propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic Acid

This fascinating compound, recognized for its unique structure and potential applications, is part of the boronic acid family. Here are some intriguing points to consider:

  • Role in Drug Discovery: Compounds containing boronic acids are often utilized in medicinal chemistry. They play a significant role in the design of inhibitors for various enzymes and receptors, particularly in the field of cancer research.
  • Structural Complexity: The complexity of its structure, with multiple functional groups and bromine atoms, enables it to interact with biological molecules in unique ways, potentially leading to innovative therapeutic avenues.
  • Protease Inhibitor Potential: The design of this compound suggests that it may serve as a protease inhibitor, which is highly relevant in the development of antiviral treatments, especially those targeting enzymes crucial for viral replication.
  • Reactivity with Biomolecules: The boronic acid moiety in this compound can form reversible covalent bonds with diols, making it a powerful tool in the design of targeted drug delivery systems and biosensors.
  • Research in Organic and Medicinal Chemistry: The investigation of compounds like this one is immensely valuable in the academic community, often leading to breakthroughs in the development of new pharmaceuticals.

This compound embodies the intersection of intricate organic synthesis and biological application, making it a subject of ongoing research and exploration in the fields of chemistry and pharmacology.