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4-Phenylbutyric acid

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Identification
Molecular formula
C10H12O2
CAS number
1821-12-1
IUPAC name
4-phenylbutanoic acid
State
State

4-Phenylbutyric acid generally exists as a solid at room temperature.

Melting point (Celsius)
49.00
Melting point (Kelvin)
322.00
Boiling point (Celsius)
304.50
Boiling point (Kelvin)
577.70
General information
Molecular weight
164.21g/mol
Molar mass
164.2080g/mol
Density
1.0790g/cm3
Appearence

4-Phenylbutyric acid is a white crystalline solid. It typically appears as a powder and may give off a faint aromatic odor.

Comment on solubility

Solubility of 4-phenylbutanoic acid

4-phenylbutanoic acid (C10H12O2) presents interesting solubility characteristics that can affect its applications in various fields. As an aromatic carboxylic acid, it exhibits a certain degree of polarity due to the presence of the carboxylic functional group, which enhances its interaction with polar solvent molecules.

Key Points on Solubility:

  • Solvent Interaction: The polar carboxyl group (-COOH) allows 4-phenylbutanoic acid to dissolve in polar solvents such as water, but the hydrophobic phenyl ring may limit its solubility compared to more polar compounds.
  • Temperature Dependence: Solubility can be affected by temperature; typically, increasing temperature enhances solubility for organic acids.
  • pH Influence: Adjusting the pH can also impact solubility—at higher pH levels, the acid can deprotonate, increasing its solubility in aqueous solutions.
  • Practical Applications: The solubility characteristics are crucial for its use in pharmaceuticals and organic synthesis, where the ability to dissolve in various solvents is essential.

Overall, the solubility of 4-phenylbutanoic acid is a balance between its polar and nonpolar characteristics, making it moderately soluble in water while being more readily soluble in organic solvents. Understanding these properties is vital for researchers and practitioners working with this compound.

Interesting facts

Interesting Facts About 4-Phenylbutanoic Acid

4-Phenylbutanoic acid, also known as 4-phenylbutanoate, is a compound that piques the interest of chemists due to its unique structure and potential applications. Here are some fascinating aspects of this aromatic carboxylic acid:

  • Structural Characteristics: The compound features a 4-phenyl group attached to a butanoic acid backbone, showcasing how aromatic systems can modify the properties of fatty acid chains.
  • Biological Significance: It is known for its role in biological systems, particularly as a metabolic intermediate. The presence of the phenyl group can enhance its interaction with proteins and enzymes.
  • Potential Applications: 4-Phenylbutanoic acid has been studied for its potential applications in pharmaceuticals and agrochemicals. Researchers are exploring its use as a building block for synthesizing more complex molecules.
  • Research Utility: In the context of drug development, derivatives of this compound have shown activity as anti-inflammatory agents. Its structure serves as a model for studying similar compounds.
  • Synthesis: The synthesis of 4-phenylbutanoic acid can be achieved through various methods, one of which is the Friedel-Crafts acylation, which illustrates the versatility of carbon chain extensions in organic synthesis.

As a chemistry student, one can appreciate how compounds like 4-phenylbutanoic acid illustrate the blend of organic chemistry's elegance and the importance of structure in determining function. Its study reflects a broader understanding of how *carbon-based compounds* play a crucial role in both nature and industry.

In the words of a prominent chemist, "Understanding the behavior of compounds like 4-phenylbutanoic acid not only enhances our knowledge but also broadens the horizons for innovation in chemical applications."

Synonyms
4-PHENYLBUTYRIC ACID
4-Phenylbutanoic acid
1821-12-1
Benzenebutanoic acid
Benzenebutyric acid
Phenylbutyrate
Phenylbutyric acid
gamma-Phenylbutyric acid
omega-Phenylbutanoic acid
Butyric acid, 4-phenyl-
4-PHENYL-BUTANOIC ACID
1-Phenylbutyric acid
4-Phenyl-n-butyric acid
GAMMA-PHENYL-BUTYRIC ACID
omega-phenylbutyric acid
CHEBI:41500
gamma-Phenyl-n-butyric acid
4-Phenyl-butyric acid
4-PHENYLBUTYRIC-2,2,3,3-D4 ACID
NSC 295
PHENYLBUTANOIC ACID
UNII-7WY7YBI87E
.gamma.-Phenylbutyric acid
461391-24-2
EINECS 217-341-8
7WY7YBI87E
MFCD00004403
AI3-12065
NSC-295
.omega.-Phenylbutanoic acid
MLS000069408
PBA
4-Phenylbutyric acid (4-PBA)
DTXSID2037631
EC 217-341-8
SMR000059104
4-Phenyl butyric acid
gamma-Phenylbutanoic acid
NCGC00018113-03
HDInhib_000004
Benzenebutyrate
Benzenebutanoate
g-Phenylbutyrate
g-Phenylbutanoate
w-Phenylbutanoate
g-phenyl-Butyrate
4-phenyl-Butyrate
2-methyl-1-phenyl-propan-2-amine
gamma-Phenylbutyrate
g-Phenylbutyric acid
gamma-Phenylbutanoate
omega-Phenylbutanoate
4-Phenyl-n-butyrate
g-Phenylbutanoic acid
gamma-phenyl-Butyrate
w-Phenylbutanoic acid
4-Phenylbutyric acid sodium 100 microg/mL in Acetonitrile:Water
g-phenyl-Butyric acid
Spectrum_001331
2ay7
3tz2
Opera_ID_387
SpecPlus_000814
Spectrum2_001798
Spectrum3_000782
Spectrum4_000092
Spectrum5_001003
4-PBA;Benzenebutyric acid
bmse000701
Epitope ID:167707
SCHEMBL1716
CHEMBL1469
3-phenylpropylcarboxylic acid
4-Phenylbutyric acid, 99%
BSPBio_002484
KBioGR_000384
KBioSS_001811
MLS001076482
DivK1c_006910
SPBio_001755
.gamma.-Phenyl-n-butyric acid
GTPL8480
NSC295
DTXCID0017631
KBio1_001854
KBio2_001811
KBio2_004379
KBio2_006947
KBio3_001704
OBKXEAXTFZPCHS-UHFFFAOYSA-
HMS2234G14
HMS3259M07
BCP10715
CS-D1686
HY-A0281
STR05306
BDBM50480960
CCG-39733
CX1106
s3592
STL164372
AKOS000154540
AC-3254
DB06819
FP26946
NC00469
PS-4322
NCGC00018113-01
NCGC00018113-02
NCGC00018113-04
NCGC00018113-18
DA-60378
NCI60_002455
NCI60_020145
SY004771
NS00008326
P0643
EN300-35719
C21793
BRD-K67102207-001-02-6
BRD-K67102207-236-01-0
BRD-K67102207-236-06-9
BRD-K67102207-236-07-7
BRD-K67102207-236-08-5
Q27088364
F2190-0002
Z234895119
Benzenebutanoic acid;4-Phenyl-n-butyric acid;gamma-Phenylbutanoic acid
1262970-43-3
217-341-8
InChI=1/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)