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Ketoprofen

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Identification
Molecular formula
C16H14O3
CAS number
22071-15-4
IUPAC name
4-oxo-4-(4-phenylphenyl)butanoic acid
State
State

At room temperature, Ketoprofen is in a solid state, appearing as a white crystalline powder.

Melting point (Celsius)
94.50
Melting point (Kelvin)
367.70
Boiling point (Celsius)
384.50
Boiling point (Kelvin)
657.70
General information
Molecular weight
254.28g/mol
Molar mass
254.2820g/mol
Density
1.2040g/cm3
Appearence

Ketoprofen appears as a white crystalline powder. It is odorless and has a slightly bitter taste. The crystals are generally needle-like or elongated.

Comment on solubility

Solubility of 4-oxo-4-(4-phenylphenyl)butanoic acid (C16H14O3)

4-oxo-4-(4-phenylphenyl)butanoic acid exhibits unique solubility characteristics, primarily influenced by its molecular structure. This compound's solubility can be detailed as follows:

  • Polar vs. Non-polar: The presence of the carboxylic acid functional group contributes to its polar nature, which typically enhances solubility in polar solvents such as water.
  • Organic Solvents: Conversely, due to its significant non-polar aromatic character, it is more soluble in organic solvents like ethanol or acetone.
  • pH Influence: The solubility of the acid form can be affected by the pH of the solution. In basic conditions, the carboxylic acid can deprotonate, leading to increased solubility in aqueous solutions as a salt.
  • Concentration: Its solubility can vary significantly with concentration, making it important to consider the specific concentration for practical applications.

Hence, it can be summarized that:

  • In polar solvents: Moderate solubility due to the polar functional group.
  • In non-polar solvents: Higher solubility owing to the aromatic components of the molecule.

Understanding these solubility traits is crucial for applications in pharmaceuticals, materials science, and chemical synthesis, allowing chemists to tailor conditions for optimal use.

Interesting facts

Interesting Facts about 4-Oxo-4-(4-phenylphenyl)butanoic Acid

4-Oxo-4-(4-phenylphenyl)butanoic acid is a fascinating compound that showcases the intersection of organic chemistry and material science. This compound belongs to a class of molecules known as diketones, which possess two carbonyl (C=O) functional groups. Here are some engaging insights about this unique chemical:

  • Versatile Applications: The structural characteristics of this acid make it useful in various fields, including pharmaceuticals, polymer science, and organic synthesis.
  • Unique Structure: The presence of two distinct phenyl groups contributes to its intriguing physical and chemical properties, such as enhanced stability and solubility characteristics, which are essential for many applications.
  • Key Intermediate: This compound often serves as an intermediary in synthetic pathways for creating more complex organic compounds.
  • Potential for Natural Products: With its unique architecture, researchers are exploring its potential as a building block in the synthesis of natural products and bioactive molecules.

As quote often reminds us in the scientific community, "The beauty of chemistry lies in its diversity." This compound is a testament to that beauty, exhibiting a blend of functionality and complexity that is both captivating and significant in the world of chemistry.

Further studies on 4-oxo-4-(4-phenylphenyl)butanoic acid may reveal additional properties and interactions that could broaden its applicability, making it an exciting area of research for chemists and material scientists alike.

Synonyms
fenbufen
36330-85-5
Lederfen
Cinopal
Bufemid
Napanol
4-(4-Biphenylyl)-4-oxobutyric acid
3-(4-Phenylbenzoyl)propionic acid
3-(4-Biphenylylcarbonyl)propionic acid
Fenbufene
4-([1,1'-biphenyl]-4-yl)-4-oxobutanoic acid
4-(biphenyl-4-yl)-4-oxobutanoic acid
Fenbufenum
gamma-Oxo(1,1'-biphenyl)-4-butanoic acid
4-oxo-4-(4-phenylphenyl)butanoic acid
CL-82204
3-(4-Biphenylcarbonyl)propionic acid
Fenbufene [INN-French]
Fenbufenum [INN-Latin]
CL 82204
4-(4-biphenyl)-4-oxobutyric acid
4-biphenyl-4-yl-4-oxobutanoic acid
Butyric acid 4-(4-biphenyl)-4-oxo-
beta,p-Phenylbenzoylpropionic acid
Propionic acid, 3-(4-biphenylylcarbonyl)-
EINECS 252-979-0
MFCD00056701
NSC-757812
BRN 2378560
Diphenyl-4-gamma-oxo-gamma-butyric acid
MLS000069810
DTXSID9023043
CHEBI:31599
CL 82,204
Fenbufen [USAN:INN:BAN:JAN]
9815R1WR9B
FENBUFEN [USAN]
FENBUFEN [INN]
FENBUFEN [JAN]
FENBUFEN [MI]
FENBUFEN [MART.]
FENBUFEN [WHO-DD]
[1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo-
(1,1'-BIPHENYL)-4-BUTANOIC ACID, gamma-OXO-
SMR000059150
CHEMBL277522
DTXCID703043
FENBUFEN [EP MONOGRAPH]
4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid
3-10-00-03334 (Beilstein Handbook Reference)
NSC 757812
Fenbufen 100 microg/mL in Acetonitrile
NCGC00016834-01
Fenbufene (INN-French)
Fenbufenum (INN-Latin)
CAS-36330-85-5
FENBUFEN (MART.)
FENBUFEN (EP MONOGRAPH)
(1,1'-BIPHENYL)-4-BUTANOIC ACID, .GAMMA.-OXO-
Cinopol
4-(1,1'-biphenyl-4-yl)-4-oxobutanoic acid
SR-01000721906
UNII-9815R1WR9B
Lederfen cp
Lederfen f
Fenbufen,(S)
Prestwick_567
3-(4-Phenyl)benzoyl propionic acid
Fenbuzip 300
Fenbuzip 450
Lederfen 450
Fenbufen (Standard)
Fenbufen, 96%
Spectrum_001248
Opera_ID_464
Prestwick0_000218
Prestwick1_000218
Prestwick2_000218
Prestwick3_000218
Spectrum2_001389
Spectrum3_001430
Spectrum4_000411
Spectrum5_001528
SCHEMBL25117
BSPBio_000235
BSPBio_003140
Fenbufen, analytical standard
KBioGR_000702
KBioSS_001728
MLS001074090
DivK1c_000025
SPECTRUM1501008
SPBio_001378
SPBio_002156
BPBio1_000259
Fenbufen (JP17/USAN/INN)
HMS500B07
HY-B1138R
KBio1_000025
KBio2_001728
KBio2_004296
KBio2_006864
KBio3_002360
M01AE05
NINDS_000025
HMS1568L17
HMS1921B13
HMS2090G14
HMS2092B03
HMS2095L17
HMS2235I24
HMS3372M18
HMS3712L17
HMS3885N06
Pharmakon1600-01501008
4-biphenyl-4-yl-4-oxobutyric acid
BCP12106
HY-B1138
PXB94096
.beta.,p-Phenylbenzoylpropionic acid
Tox21_110638
BDBM50240374
CCG-38988
NSC757812
s4526
STK202178
4-biphenyl-4-yl-4-oxo-butyric acid
AKOS000200430
Tox21_110638_1
CS-4743
DB08981
SS-4225
3-(4'-biphenylcarbonyl) propanoic acid
IDI1_000025
3-(4-biphenylylcarbonyl)-propionic acid
NCGC00016834-02
NCGC00016834-03
NCGC00016834-04
NCGC00016834-07
NCGC00094886-01
NCGC00094886-02
NCGC00094886-03
AC-14459
SBI-0051631.P002
AB00052195
gamma-oxo(1,1''-biphenyl)-4-butanoic acid
gamma-Oxo-(1,1'-biphenyl)-4-butanoic acid
NS00008115
.gamma.-Oxo(1,1'-biphenyl)-4-butanoic acid
Diphenyl-4-.gamma.-oxo-.gamma.-butyric acid
EN300-14196
4-([1,1'-biphenyl]-4-yl)-4-oxobutanoicacid
4-[1,1''-biphenyl-4-yl]-4-oxobutanoic acid
D01344
4-[1,1'-Biphenyl]-4-yl-4-oxobutanoic acid #
AB00052195-13
AB00052195_14
Q2304195
SR-01000721906-2
SR-01000721906-4
SR-01000721906-5
BRD-K12513978-001-05-0
BRD-K12513978-001-16-7
BRD-K12513978-001-24-1
Z99599540
Fenbufen, European Pharmacopoeia (EP) Reference Standard
252-979-0