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4-Nitrophenol

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Identification
Molecular formula
C6H5NO3
CAS number
100-02-7
IUPAC name
4-nitrophenol
State
State
Solid at room temperature, 4-nitrophenol is generally found in its crystalline form.
Melting point (Celsius)
114.00
Melting point (Kelvin)
387.00
Boiling point (Celsius)
279.00
Boiling point (Kelvin)
552.00
General information
Molecular weight
139.11g/mol
Molar mass
139.1110g/mol
Density
1.4790g/cm3
Appearence
4-Nitrophenol typically appears as a yellow crystalline solid. It has a slightly sweet, phenolic odor.
Comment on solubility

Solubility of 4-Nitrophenol (C6H5NO3)

4-Nitrophenol, a nitro-substituted phenolic compound, exhibits interesting solubility characteristics. Its solubility behavior can largely be attributed to its molecular structure, which influences its interactions with solvents.

Solubility Characteristics:

  • Solvent Compatibility: 4-nitrophenol is known to be more soluble in organic solvents such as ethanol and acetone compared to water.
  • Water Solubility: It possesses limited solubility in water, estimated around 0.5 g/100 mL at room temperature, primarily due to its hydrophobic phenyl ring and the polar nitro group.
  • Temperature Dependency: Solubility in water tends to increase with temperature, demonstrating typical behavior for many organic solids.

The unique solubility profile of 4-nitrophenol underscores its utility in various applications. According to scientific literature, “the solubility in organic solvents makes 4-nitrophenol an excellent candidate for various synthetic processes and as an intermediate in chemical synthesis.”

Overall, understanding the solubility of 4-nitrophenol is crucial for effectively utilizing this compound in both industrial and laboratory settings.

Interesting facts

Interesting Facts about 4-Nitrophenol

4-Nitrophenol, also referred to as para-nitrophenol, is a fascinating aromatic compound with a variety of applications and properties that make it noteworthy:

  • Chemical Structure: The unique structure of 4-nitrophenol features a nitro group (-NO2) positioned at the para position relative to the hydroxyl group (-OH) on the benzene ring. This configuration enhances its reactivity and solubility in various organic solvents.
  • Industrial Uses: 4-Nitrophenol serves as a crucial intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is also utilized in the production of explosives and as a disinfectant in certain formulations.
  • Biological Importance: This compound exhibits various biological activities, including antimicrobial properties. Some studies highlight its potential effects on enzymes and its interactions with cellular processes, making it a subject of interest in biochemical research.
  • Environmental Concerns: Due to its toxicity and potential for environmental contamination, the handling and disposal of 4-nitrophenol must be approached with caution. Regulatory agencies have set standards to minimize risks associated with its use.
  • Color Change: 4-Nitrophenol is known for its ability to undergo color changes depending on the pH of the solution it's in. This characteristic is often explored in laboratory experiments, serving as an acid-base indicator.

The versatility of 4-nitrophenol exemplifies the intricate roles that organic compounds play in both industrial and scientific contexts. With its diverse applications and intriguing properties, it continues to be an essential compound for chemists and researchers alike.

Synonyms
4-Nitrophenol
p-nitrophenol
100-02-7
Phenol, 4-nitro-
Paranitrophenol
Niphen
4-Hydroxynitrobenzene
p-Hydroxynitrobenzene
para-nitrophenol
Phenol, p-nitro-
Mononitrophenol
Paranitrofenol
Paranitrofenolo
p-Nitrofenol
4-Nitrofenol
Caswell No. 603
RCRA waste number U170
NCI-C55992
p-Nitrofenol [Czech]
Paranitrofenol [Dutch]
4-Nitrofenol [Dutch]
Paranitrophenol [French,German]
Paranitrofenolo [Italian]
1-Hydroxy-4-nitrobenzene
PNP
UN1663
CCRIS 2316
EPA Pesticide Chemical Code 056301
CHEBI:16836
HSDB 1157
4-nitro-phenol
AI3-04856
RCRA waste no. U170
NSC 1317
EINECS 202-811-7
UNII-Y92ZL45L4R
MFCD00007331
DTXSID0021834
NITROPHENOL, P-
NSC-1317
PHENOL,4-NITRO
P-NITROPHENOL [MI]
4-NITROPHENOL [HSDB]
P-NITROPHENOL [MART.]
DTXCID201834
SR-1C2
Y92ZL45L4R
EC 202-811-7
p-Nitrophenol [UN1663] [Poison]
PARACETAMOL IMPURITY F [EP IMPURITY]
P-NITROPHENOL (MART.)
CAS-100-02-7
Nitrophenol (para)
NPO
PARACETAMOL IMPURITY F (EP IMPURITY)
4-Nitrophenol Solution in Methanol, 100ug/mL
pNitrofenol
pNitrophenol
4nitrophenol
4Nitrofenol
p-nitro phenol
Phenol, pnitro
4-nitryl phenol
4- nitrophenol
4-nitro phenol
4-nitrophenol-
Phenol, 4nitro
3qvu
phenol, 4-nitro
pHydroxynitrobenzene
4Hydroxynitrobenzene
RPN
para-hydroxynitrobenzene
WLN: WNR DQ
4-Hydroxy-1-nitrobenzene
bmse000223
Epitope ID:161303
O2NC6H4OH
SCHEMBL1839
CHEMBL14130
SGCUT00249
4-Nitrophenol, puriss., 99%
SCHEMBL13906248
SCHEMBL14501907
BDBM31678
CHEBI:39362
NSC1317
4-Nitrophenol, Reference Material
to_000002
Tox21_202444
Tox21_300117
4-Nitrophenol, reagent grade, 98%
MSK9037-100M
s6196
STL281865
AKOS000118985
4-Nitrophenol, spectrophotometric grade
DB04417
FN00318
RP10002
USEPA/OPP Pesticide Code: 056301
NCGC00247904-01
NCGC00247904-02
NCGC00254220-01
NCGC00259993-01
1ST9037-100M
4-Nitrophenol 100 microg/mL in Methanol
4-Nitrophenol, ReagentPlus(R), >=99%
AS-13146
BP-20405
4-Nitrophenol 10 microg/mL in Acetonitrile
DS-005476
N0161
N0162
N0220
NS00010495
EN300-18010
4-Nitrophenol, JIS special grade, >=99.0%
C00870
4-Nitrophenol, PESTANAL(R), analytical standard
A800004
AE-562/40217722
Q656269
Z57127483
F9995-1636
4-Nitrophenol, certified reference material, TraceCERT(R)