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2-Amino-4-methylpyridine

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Identification
Molecular formula
C6H8N2
CAS number
695-34-1
IUPAC name
4-methylpyridin-2-amine
State
State

2-Amino-4-methylpyridine is in a solid state at room temperature.

Melting point (Celsius)
56.00
Melting point (Kelvin)
329.15
Boiling point (Celsius)
216.00
Boiling point (Kelvin)
489.15
General information
Molecular weight
108.14g/mol
Molar mass
108.1440g/mol
Density
1.0050g/cm3
Appearence

2-Amino-4-methylpyridine appears as a crystalline solid. It is often colorless to pale yellow in appearance. Its crystalline nature reflects light, giving it a shiny or glossy look under proper lighting conditions.

Comment on solubility

Solubility of 4-methylpyridin-2-amine (C6H8N2)

4-methylpyridin-2-amine, with its unique molecular structure, exhibits interesting solubility characteristics that can be significant in various chemical applications. Notably, its solubility is influenced by the presence of both the pyridine nitrogen and amino group, which enhance its ability to interact with different solvents. Here’s a closer look:

  • Water Solubility: 4-methylpyridin-2-amine is moderately soluble in water. This solubility can be attributed to hydrogen bonding capabilities due to the amino group.
  • Solvents Compatibility: It is commonly soluble in polar organic solvents such as:
    • Alcohols (e.g., ethanol, methanol)
    • Dimethyl sulfoxide (DMSO)
    • Aqueous solutions of acids
  • Temperature Influence: As with many organic compounds, its solubility tends to increase with temperature, allowing for better dissolution in hotter solvent mixtures.

In summary, the solubility of 4-methylpyridin-2-amine underscores its versatility as a chemical, making it a suitable candidate for various synthetic processes and reactions. As one might say, "Understanding the solubility of a compound is crucial in tapping into its full potential." Overall, the compound's amphipathic characteristics contribute significantly to its solvation behavior.

Interesting facts

Interesting Facts about 4-Methylpyridin-2-amine

4-Methylpyridin-2-amine, often abbreviated as 4-MP, is a fascinating compound with numerous applications in both industrial and research settings. Here are some intriguing insights:

  • Structure and Reactivity: The compound features a pyridine ring, a six-membered aromatic ring that plays a crucial role in the properties of heterocyclic compounds. This makes 4-MP a valuable scaffold for various chemical reactions, particularly in medicinal chemistry.
  • Biological Significance: 4-MP is of interest due to its potential biological activities. Its structural similarities to other biologically active compounds highlight its potential as a lead compound in drug development.
  • Applications in Synthesis: In synthetic chemistry, 4-MP serves as a versatile intermediate. It is utilized in creating more complex molecules through reactions such as nucleophilic substitution and coupling reactions, which are pivotal in the development of pharmaceuticals.
  • Environmental Impact: 4-MP has also been investigated for its role in environmental science, particularly concerning its behavior in various environmental compartments and its impact on aquatic systems.
  • Research Applications: Scholars often explore 4-MP for its potential applications in catalysis and materials science, where its unique electronic properties can be harnessed to create innovative functional materials.
  • Historical Context: The study of pyridine derivatives such as 4-MP has a rich history dating back to the early 19th century, contributing significantly to the fields of organic chemistry and pharmacology.

As a chemistry student, exploring the structural and chemical aspects of 4-methylpyridin-2-amine can deepen your understanding of aromatic compounds and their transformations, while also offering a glimpse into the interdisciplinary connections between chemistry, biology, and environmental science.

Synonyms
2-amino-4-methylpyridine
4-METHYLPYRIDIN-2-AMINE
695-34-1
2-Amino-4-picoline
Aminopicoline
2-Pyridinamine, 4-methyl-
Ascensil
4-Methyl-2-pyridinamine
4-Methyl-2-pyridylamine
4-Methyl-2-aminopyridine
4-PICOLINE, 2-AMINO-
W 45 Raschig
Pyridine, 2-amino-4-methyl-
Methyl-4 amino-2-pyridine
4M2AP
VMI 20-4
4-methylpyridin-2-ylamine
RA 1226
2-Amino-.gamma.-picoline
NSC 1490
NSC 6972
EINECS 211-780-9
MFCD00006321
BRN 0107066
DTXSID1044720
UNII-394N1Z644H
W 45
AI3-23984
NSC-1490
NSC-6972
2-amino-4-methyl-pyridine
4-Methyl-pyridin-2-ylamine
CHEMBL40833
DTXCID9024720
2-AMINO-4-PICOLINE [MI]
2-amino-4-methyl pyridine
5-22-09-00325 (Beilstein Handbook Reference)
AMINO-4-METHYLPYRIDINE, 2-
(4-METHYLPYRIDIN-2-YL)AMINE
394N1Z644H
NSC-176165
RA-1226
RIFAXIMIN IMPURITY A [EP IMPURITY]
WLN: T6NJ BZ D1
alpha-Amino-gamma-picoline
BVF
RIFAXIMIN IMPURITY A (EP IMPURITY)
4-methylpyridyl amine
Tocris-1020
2-Amino-gamma-picoline
2-amino4-methylpyridine
4-methyl-pyridin-2-amine
4-methyl-2-amino-pyridine
2-Amino-4-methylpyridine (2-Amino-4-picoline)
SCHEMBL25153
GTPL5111
.alpha.-Amino-.gamma.-picoline
SCHEMBL21515309
(4-methyl-pyridin-2-yl)-amine
NSC1490
NSC6972
2-Amino-4-methylpyridine, 99%
BCP05096
STR00701
Tox21_301597
4-METHYLPYRIDIN-2-AMINE, 6
AB2620
BDBM50091800
HSCI1_000374
STK385035
AKOS000119085
AB00703
AC-2481
CS-W003969
FA45037
HY-W003969
PS-9285
SB75552
NCGC00024943-01
NCGC00256313-01
CAS-695-34-1
W-45
DB-024215
A0402
A5223
A9196
NS00036880
EN300-21467
AC-907/25014131
SR-01000597673
SR-01000597673-1
BRD-K74039237-001-01-7
Q24755764
F1995-0205
Z203045032