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Tosylamide

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Identification
Molecular formula
C7H9NO2S
CAS number
70-55-3
IUPAC name
4-methylbenzenesulfonamide
State
State

At room temperature, Tosylamide is typically found in a solid state.

Melting point (Celsius)
137.00
Melting point (Kelvin)
410.15
Boiling point (Celsius)
216.00
Boiling point (Kelvin)
489.15
General information
Molecular weight
171.22g/mol
Molar mass
171.2160g/mol
Density
1.2400g/cm3
Appearence

Tosylamide is a white crystalline solid. It has a characteristic sulfonamide odor.

Comment on solubility

Solubility of 4-methylbenzenesulfonamide

4-methylbenzenesulfonamide, with the chemical formula C7H9NO2S, exhibits notable solubility characteristics that are important for its application in various chemical processes.

Solubility Characteristics

  • Solvent Interaction: This compound is primarily soluble in polar solvents due to the presence of the sulfonamide group, which can form hydrogen bonds.
  • Water Solubility: 4-methylbenzenesulfonamide shows moderate solubility in water. The electrostatic interactions between water molecules and the sulfonamide functional group contribute to this solubility.
  • Organic Solvents: It is also soluble in a variety of organic solvents, making it versatile for organic synthesis.
  • Temperature Dependence: Like many organic compounds, solubility can change with temperature; generally, higher temperatures tend to increase solubility.

These properties can aid in predicting the behavior of 4-methylbenzenesulfonamide in laboratory settings and industrial applications. Understanding its solubility is essential for effectively utilizing this compound in various chemical reactions and formulations.

Interesting facts

Interesting Facts about 4-Methylbenzenesulfonamide

4-Methylbenzenesulfonamide, commonly known as *p-toluenesulfonamide*, is a fascinating compound that holds significance in both scientific research and industrial applications.

Key Highlights:

  • Pharmaceutical Relevance: This compound is often utilized in the pharmaceutical industry due to its ability to act as a sulfonamide, which is a class of compounds that have shown antimicrobial properties. They have been pivotal in the development of various antibiotics.
  • Versatile Building Block: 4-Methylbenzenesulfonamide serves as an important precursor in synthetic organic chemistry. It can be modified to create a diverse range of chemicals including dyes, plastics, and other biologically active molecules.
  • Applications in Research: Researchers often employ 4-methylbenzenesulfonamide in the study of enzyme inhibitors as it can effectively modulate biological activity; it is particularly useful for studying sulfamides.
  • Physical Properties: Though the individual properties of the compound are interesting, its ability to form strong hydrogen bonds makes it a useful component in various chemical reactions.

Did You Know?

  • 4-Methylbenzenesulfonamide has been the focus of studies investigating its potential roles in cancer research.
  • This compound also has applications in the dyeing and textile industries due to its ability to bind effectively to various substrates.

The world of 4-methylbenzenesulfonamide is a perfect example of how a single compound can have multifaceted roles across various fields, illustrating the beauty of chemistry and its applications in our everyday lives. As one prominent chemist once said, "Chemistry is the magic that happens between atoms."

Synonyms
P-TOLUENESULFONAMIDE
4-Methylbenzenesulfonamide
70-55-3
4-Toluenesulfonamide
Tosylamide
p-Tosylamide
Toluene-4-sulfonamide
Benzenesulfonamide, 4-methyl-
para-Toluenesulfonamide
p-Tolylsulfonamide
4-methylbenzene-1-sulfonamide
p-Methylbenzenesulfonamide
p-Toluenesulfonylamide
Tolylsulfonamide
p-Toluenesulfamide
Toluene-4-sulphonamide
Toluene-p-sulphonamide
4-Toluenesulfanamide
TOLUENESULFONAMIDE, P-
4-Toluenesulfonic acid, amide
tosylamine
HSDB 5203
NSC 9908
NSC-9908
4-tolylsulfonamide
EINECS 200-741-1
MFCD00011692
BRN 0472689
p-toluene sulphonamide
DTXSID8029105
CHEBI:34435
Paratoulene sulfonamide
AI3-19503
I8266RI90M
4-methylbenzenesulphonamide
CHEMBL574
DTXCID109105
EC 200-741-1
P-TOLUENESULFONAMIDE [HSDB]
4-11-00-00376 (Beilstein Handbook Reference)
P-TOLUENESULFONAMIDE [USP-RS]
TOLBUTAMIDE IMPURITY A [EP IMPURITY]
P-TOLUENESULFONAMIDE (USP-RS)
CAS-70-55-3
TOLBUTAMIDE IMPURITY A (EP IMPURITY)
pTosylamide
UNII-I8266RI90M
pToluenesulfamide
pTolylsulfonamide
p-toluensulfonamide
4Toluenesulfanamide
Toluene4sulfonamide
Toluenepsulphonamide
4-tolylsulphonamide
4J8
p-Toluenesulfanamide
pToluenesulfonylamide
p-Toluenesulphonamide
para-Toluenesulfamine
paraToluenesulfonamide
4-toluenesulphonamide
p-toluene sulfonamide
p-toluene-sulfonamide
PASAM
Toluene-p-sulfonamide
4-toluenesulfonylamide
N-p-tolylsulfonylamine
Tolbutamide impurity a
p-toluenesulfonic amide
para-toluenesulphonamide
pMethylbenzenesulfonamide
para-toluen sulphonamide
4Methylbenzenesulfonamide
para-toluene sulphonamide
4-methylphenylsulphonamide
4-methylphenyl sulfonamide
P-Toluenesulfonamide,(S)
4-methyl benzenesulfonamide
4-methyl-benzenesulfonamide
WLN: ZSWR D1
4-methylphenylsulphonylamine
Benzenesulfonamide, 4methyl
p-methyl-benzene sulfonamide
SCHEMBL7370
4Toluenesulfonic acid, amide
MLS001065595
BIDD:ER0609
PTS100
BDBM10859
benzene, 1-methyl-4-sulphamoyl-
NSC9908
PTS 100
HMS3039B12
Tox21_201594
Tox21_303506
aromatic/heteroaromatic sulfonamide 4
STK416410
AKOS000149655
FS-3585
NCGC00091435-01
NCGC00091435-02
NCGC00091435-03
NCGC00257435-01
NCGC00259143-01
BP-12584
HY-79602
NCI60_042220
p-Toluenesulfonamide, reagent grade, 98%
SMR000568494
GLICLAZIDE IMPURITY A [EP IMPURITY]
CS-0012133
NS00010636
T0281
EN300-15721
p-Toluenesulfonamide, ReagentPlus(R), >=99%
AE-562/40173366
p-Toluenesulfonamide, Vetec(TM) reagent grade, 98%
BRD-K62412084-001-07-1
Q23013959
Z45415564
F0722-8812
p-Toluenesulfonamide, United States Pharmacopeia (USP) Reference Standard
12552-95-3
200-741-1