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1,3-Benzenedicarboxamide, 4-methoxy-N,N'-bis(3-pyridinylmethyl)-

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Identification
Molecular formula
C21H21N3O4
CAS number
134659-32-2
IUPAC name
4-methoxy-N1,N3-bis(3-pyridylmethyl)benzene-1,3-dicarboxamide
State
State

At room temperature, this compound is generally found in solid state. It is a stable solid and can be stored under typical laboratory conditions.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.00
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.00
General information
Molecular weight
367.39g/mol
Molar mass
367.3850g/mol
Density
1.2500g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder, which might exhibit slight variations in appearance depending on the presence of impurities or the method of synthesis.

Comment on solubility

Solubility of 4-methoxy-N1,N3-bis(3-pyridylmethyl)benzene-1,3-dicarboxamide

The solubility of 4-methoxy-N1,N3-bis(3-pyridylmethyl)benzene-1,3-dicarboxamide (C21H21N3O4) is an intriguing subject due to its complex structure and functional groups.

Generally, the solubility of a compound can be influenced by several factors:

  • Polarity: The presence of polar functional groups in this compound, such as carboxamide and methoxy groups, suggests potential for dissolution in polar solvents, particularly water.
  • Hydrogen bonding: The amide groups in the structure could facilitate hydrogen bonding with water molecules, enhancing solubility.
  • Substituents: The pyridylmethyl substituents introduce additional complexities, impacting how the molecule interacts with various solvents.

Furthermore, it is crucial to take into account:

  • The effect of temperature, which generally increases solubility for most compounds.
  • The presence of co-solvents that may alter the solubility profile.

In summation, while exact solubility data for this compound may not be readily available, its structure implies a reasonable expectation for moderate solubility in polar solvents, accentuated by the potential for hydrogen bonding. To fully ascertain its solubility characteristics, experimental determination would be beneficial.

Interesting facts

Interesting Facts about 4-methoxy-N1,N3-bis(3-pyridylmethyl)benzene-1,3-dicarboxamide

4-methoxy-N1,N3-bis(3-pyridylmethyl)benzene-1,3-dicarboxamide is a fascinating compound that showcases the rich interplay of organic chemistry and medicinal applications. Here are some intriguing aspects:

  • Unique Structure: This compound features a complex structure that includes a benzene ring connected to multiple functional groups, which can provide significant chemical reactivity and versatility.
  • Pyridine Interaction: The presence of pyridyl groups not only enhances solubility in various solvents but also plays a crucial role in biological interactions, making it useful in pharmacological applications.
  • Potential Applications: Compounds of this nature can be investigated for their potential in drug development, particularly due to their ability to interact with biological systems effectively. Research into similar amides has shown promise in anti-cancer, anti-inflammatory, and anti-microbial therapies.
  • Research Opportunities: The diverse functional groups present open up pathways for new reactions, and this compound can serve as a basis for synthesizing even more complex molecules, beneficial in the field of materials science and drug discovery.
  • Mechanism of Action: Understanding how this compound interacts at the molecular level with biological targets is a critical area of research, potentially leading to breakthroughs in therapeutic methodologies.

In conclusion, 4-methoxy-N1,N3-bis(3-pyridylmethyl)benzene-1,3-dicarboxamide stands at the crossroads of chemistry and biology. Its unique structural elements and potential applications in medicine make it a compelling subject for further study.

Synonyms
picotamide
32828-81-2
4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
EINECS 251-245-7
Picotamide [INN:BAN]
4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide
G-137
UNII-654G2VCI4Q
Picotamide (BAN)
NSC-304384
BRN 0499268
654G2VCI4Q
4-methoxy-N1,N3-bis(pyridin-3-ylmethyl)isophthalamide
G 137
N,N'-Bis(3-picolyl)-4-methoxyisophthalamide
PICOTAMIDE [MI]
4-Methoxy-N,N'-bis(3-pyridylmethyl)isophthalamide
PICOTAMIDE [MART.]
PICOTAMIDE [WHO-DD]
Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-
DTXSID40186498
N,N'-Bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide
5-22-09-00319 (Beilstein Handbook Reference)
NSC 304384
Plactidil (TN)
1,3-Benzenedicarboxamide, N,N'-bis(3-pyridinylmethyl)-4-methoxy-
PICOTAMIDE (MART.)
1,3-Benzenedicarboxamide, 4-methoxy-N,N'-bis(3-pyridinylmethyl)-
1,3-BENZENEDICARBOXAMIDE, 4-METHOXY-N1,N3-BIS(3-PYRIDINYLMETHYL)-
4-methoxy-N1,N3-bis((pyridin-3-yl)methyl)benzene-1,3-dicarboxamide
4-methoxy-N1,N3-bis[(pyridin-3-yl)methyl]benzene-1,3-dicarboxamide
SR-01000076086
4-Methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide
1085306-93-9
Prestwick0_000119
Prestwick1_000119
Prestwick2_000119
Prestwick3_000119
Lopac-P-8477
Lopac0_001003
BSPBio_000138
N,N'-Bis(3-pyridylmethyl)-4-methoxyisophthalamide
SCHEMBL137025
SPBio_002077
BPBio1_000152
CHEMBL1257015
CHEBI:93175
GTPL11379
DTXCID50108989
KYWCWBXGRWWINE-UHFFFAOYSA-N
HMS2090L18
HMS3263I07
HY-B1735
Tox21_501003
BDBM50103507
MFCD00866792
NSC304384
AKOS040759696
CCG-205083
DB13327
LP01003
SDCCGSBI-0050976.P003
NCGC00015847-01
NCGC00015847-02
NCGC00015847-03
NCGC00015847-04
NCGC00015847-05
NCGC00094297-01
NCGC00094297-02
NCGC00261688-01
FP146861
MS-26107
SBI-0050976.P002
DB-048275
EU-0101003
NS00029358
D07140
G63334
P 8477
L013375
Q1235921
SR-01000076086-1
BRD-K67277431-002-03-0
BRD-K67277431-002-10-5
Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-(8CI)
4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide
251-245-7
Picotamide; 1,3-Benzenedicarboxamide, 4-methoxy-N1,N3-bis(3-pyridinylmethyl)-; 1,3-Benzenedicarboxamide, 4-methoxy-N,N'-bis(3-pyridinylmethyl)- (9CI); Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)- (8CI); 4-Methoxy-N1,N3-bis(3-pyridinylmethyl)-1,3-benzenedicarb