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4-Methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline

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Identification
Molecular formula
C12H13NO3
CAS number
65373-37-3
IUPAC name
4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline
State
State

At room temperature, 4-Methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline is typically a solid. This crystalline powder is stable under normal conditions and does not easily evaporate.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
361.50
Boiling point (Kelvin)
634.65
General information
Molecular weight
217.24g/mol
Molar mass
217.2420g/mol
Density
1.2000g/cm3
Appearence

4-Methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline typically appears as a crystalline solid. The color can vary from white to slightly yellowish, depending on purity and specific conditions. It is important to note that appearance can also be influenced by the presence of impurities.

Comment on solubility

Solubility of 4-Methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline

The solubility of 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline (C12H13NO3) can be influenced by several factors, making it an intriguing compound to study.

In general, the solubility of organic compounds like this isoquinoline derivative can be categorized as follows:

  • Polarity: The presence of methoxy and dioxole groups may enhance its solubility in polar solvents like water.
  • Temperature Dependency: Solubility can increase with temperature, which is a common trend for many organic compounds.
  • pH Sensitivity: The solubility may vary depending on the pH of the solution due to potential protonation or deprotonation.
  • Solvent Interaction: It may exhibit different solubility profiles in various organic solvents (e.g., ethanol, methanol, dichloromethane).

While specific solubility data for this compound might not be readily available, one could hypothesize that the combination of functional groups suggests a moderate to good solubility in various solvents. As highlighted in chemical studies, "the solubility of a compound is a crucial property that dictates its practical applications in pharmaceuticals and material science." Therefore, conducting solubility tests in different media would be essential to fully characterize the behavior of this compound.

Interesting facts

Interesting Facts about 4-Methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline

This intriguing compound is part of the isoquinoline family, which encompasses a wide range of biologically active molecules. Here are some captivating aspects about 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline:

  • Biological Activity: Compounds featuring isoquinoline structures have been studied for various pharmacological effects, including anti-inflammatory, anti-cancer, and neuroprotective properties. This specific compound's structure hints at potential biological significance worth exploring.
  • Structural Features: The presence of the methoxy group and the dioxole ring is notable. These functional groups can significantly influence the compound's reactivity and interactions with biological systems.
  • Natural Occurrence: Isoquinoline derivatives can often be found in various plants, suggesting that this compound may have natural analogs or sources, which could lead to discoveries in natural product chemistry.
  • Chemical Synthesis: Designing synthetic pathways to create such compounds can be a complex endeavor, involving multiple steps and specific reagents. Understanding these methodologies can provide insights into organic synthesis and functional group transformations.
  • Analytical Techniques: Characterizing this compound often requires advanced techniques such as NMR (Nuclear Magnetic Resonance) spectroscopy and mass spectrometry. These tools help chemists verify purity and structure, which is essential for further studies.

In summary, 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline presents a rich area for exploration, from its potential therapeutic applications to its intriguing chemical properties. As with many complex organic molecules, there is much more than meets the eye!

Synonyms
Hydrocotarnine
550-10-7
Hydrocotarnin
4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline
4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
UNII-G22L6JNE61
G22L6JNE61
4-Methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo(4,5-g)isoquinoline
4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline
EINECS 208-978-2
MFCD00868501
HYDROCOTARNINE [MI]
BRN 0017283
1,3-DIOXOLO(4,5-g)ISOQUINOLINE, 5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-
HYDROCOTARNINE [WHO-DD]
DTXSID60203535
1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-
4-27-00-06395 (Beilstein Handbook Reference)
5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinoline
Hydrocotarnine hydrochloride (JP15)
8-methoxy-5,6-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
1,2,3,4-Tetrahydro-8-methoxy-2-methyl-6,7-methylenedioxyisoquinoline
1,2,3,4-Tetrahydro-8-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline, 9CI
5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline
NCGC00016666-01
CAS-5985-00-2
4-methoxy-6-methyl-2H,5H,6H,7H,8H-(1,3)dioxolo(4,5-g)isoquinoline
4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline
4-methoxy-6-methyl-7,8-dihydro-5H-(1,3)dioxolo(4,5-g)isoquinoline
1,2,3,4-Tetrahydro-8-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinoline, 9ci
Spectrum_000366
SpecPlus_000929
Prestwick0_000605
Prestwick1_000605
Prestwick2_000605
Prestwick3_000605
Spectrum2_001393
Spectrum3_001433
Spectrum4_001851
Spectrum5_000382
BSPBio_000510
BSPBio_002504
BSPBio_003166
KBioGR_002283
KBioSS_000846
DivK1c_007025
SCHEMBL680035
SPBio_001406
SPBio_002729
BPBio1_000562
CHEMBL1606295
CHEBI:92664
KBio1_001969
KBio2_000846
KBio2_003414
KBio2_005982
KBio3_002386
DTXCID90126026
AAA55010
BBL029075
STK802005
AKOS005068108
HY-W176629
SDCCGMLS-0066725.P001
NCGC00016666-02
NCGC00016666-03
NCGC00016666-04
DA-64317
VS-09097
AB00053339
CS-0237743
NS00033220
EN300-186673
BRD-K37447567-001-01-8
BRD-K37447567-004-05-3
Q27164371
Z1824565757
8-methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
4-methoxy-6-methyl-5,6,7,8-tetrahydro-2H-[1,3]dioxolo[4,5-g]isoquinoline
208-978-2