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4-Methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine

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Identification
Molecular formula
C12H14N4O2
CAS number
116355-84-3
IUPAC name
4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidine
State
State

This compound is typically found in a solid state at room temperature due to its crystalline structure. It is stable under standard conditions, with minimal volatization.

Melting point (Celsius)
144.00
Melting point (Kelvin)
417.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
246.28g/mol
Molar mass
246.2760g/mol
Density
1.1800g/cm3
Appearence

The compound generally appears as a white or off-white crystalline solid. The crystals can vary in size depending on the method of synthesis or purification but typically are small and powdery.

Comment on solubility

Solubility of 4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidine

The solubility of 4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidine (C12H14N4O2) can be influenced by several factors, including its molecular structure and the presence of functional groups. Generally, compounds with similar structures can exhibit:

  • Moderate Solubility in Organic Solvents: Due to the presence of methoxy groups, this compound may dissolve reasonably well in non-polar solvents like dichloromethane or ethyl acetate.
  • Limited Water Solubility: Given that pyrimidine derivatives often have hydrophobic properties, solubility in water is likely to be quite low.
  • pH Dependence: The solubility may vary with changes in pH, particularly due to the possible presence of functional groups that can protonate or deprotonate, altering their solubility characteristics.

As a rule of thumb, **chemical structures with higher numbers of alkyl or aromatic groups** tend to favor non-polar environments, whereas those with polar or ionic functional groups may enhance water solubility. Consequently, the solubility profile of C12H14N4O2 can be summarized as:

  1. Good solubility in organic solvents
  2. Poor solubility in water
  3. Potential fluctuation with pH changes

**In conclusion**, the solubility of this compound is likely *moderate to low in polar solvents and moderate in non-polar solvents*, making it necessitate appropriate solvent considerations for practical applications.

Interesting facts

Exploring 4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidine

4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidine is an intriguing compound in the realm of organic chemistry, particularly due to its structural complexity and potential applications. Here are some fascinating aspects of this compound:

  • Diverse Applications: This compound belongs to a class of molecules known as pyrimidines, which are integral to various fields. They are often explored for their potential therapeutic effects, especially in medicinal chemistry where they may serve as a basis for drug development.
  • Structural Complexity: The presence of multiple functional groups, including methoxy and pyrazole moieties, lends this compound unique pharmacological properties. The interplay between these groups can lead to interesting reactivity and interaction with biological targets.
  • Bioactivity: Compounds like this often exhibit a range of biological activities, which can include antimicrobial, antifungal, and anticancer properties. Studies may investigate the compound's efficacy against various diseases, making it a valuable subject for drug discovery.
  • Research Potential: The ongoing research into pyrimidine derivatives has led to the discovery of new compounds with significant effects in treating conditions such as diabetes and inflammation. This aspect emphasizes the compound's importance in finding new therapeutic avenues.

As a chemist or a student, delving into the synthesis and characterization of 4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidine can provide insights into both its chemical behavior and its potential as a lead compound in pharmacological research. The unique architecture of this molecule showcases the beauty of organic chemistry and highlights the importance of chemical diversity in drug design.

Synonyms
epirizole
Mepirizole
18694-40-1
Mebron
Methopyrimazole
Mepirizol
4-Methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine
DA-398
Epirizol
Epirizolum [INN-Latin]
4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
Mepirizol [German]
Epirizolum
Epirizol [INN-Spanish]
Epirizole [USAN:INN:JAN]
EINECS 242-507-1
Mebron (TN)
BRN 0751084
3B46O2FH8I
DTXSID4045422
Pyrimidine, 4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methyl-
EPIRIZOLE [INN]
EPIRIZOLE [JAN]
EPIRIZOLE [MI]
EPIRIZOLE [USAN]
EPIRIZOLE [MART.]
1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole
2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine
2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine
EPIRIZOLE [WHO-DD]
Pyrimidine,4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methyl-
MLS000028844
DTXCID2025422
4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin
4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin [German]
5-25-18-00012 (Beilstein Handbook Reference)
NCGC00016737-01
SMR000058715
Epirizol (INN-Spanish)
Epirizolum (INN-Latin)
CAS-18694-40-1
EPIRIZOLE (MART.)
2-(3-METHYL-5-METHOXY-1-PYRAZOLYL)-4-METHOXY-6-METHYL-PYRIMIDINE
UNII-3B46O2FH8I
Prestwick_201
Opera_ID_598
Prestwick0_000032
Prestwick1_000032
Prestwick2_000032
Prestwick3_000032
Epirizole (JP17/USAN)
SCHEMBL23765
BSPBio_000123
MLS001148256
MLS001424179
SPBio_002044
Mepirizole, analytical standard
BPBio1_000137
CHEMBL1411693
CHEBI:31545
HMS1568G05
HMS2052A07
HMS2095G05
HMS2232E23
HMS3370D19
HMS3394A07
HMS3712G05
Tox21_110584
Pyrimidine, 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methyl-
AKOS016000700
Tox21_110584_1
CCG-101087
DB08991
NC00337
NCGC00016737-02
NCGC00016737-04
TS-08065
HY-103595
CS-0022015
MLS000028844-02
NS00026110
D01394
G76483
SR-01000721915
Q5383219
SR-01000721915-3
BRD-K39339537-001-03-8
BRD-K39339537-001-21-0
242-507-1