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Phenazone

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Identification
Molecular formula
C11H12N2O
CAS number
60-80-0
IUPAC name
4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one
State
State
Phenazone is a solid at room temperature, appearing as a crystalline powder. It is generally stable under normal conditions.
Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
361.00
Boiling point (Kelvin)
634.15
General information
Molecular weight
188.23g/mol
Molar mass
188.2330g/mol
Density
1.1277g/cm3
Appearence

Phenazone is a crystalline powder that appears to be white or almost white. It has a characteristic odor and can sometimes appear as fine, shiny, needle-like crystals or flakes. This compound is sparingly soluble in water, but more soluble in alcohol and chloroform.

Comment on solubility

Solubility of 4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one (C11H12N2O)

The solubility of 4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one in various solvents provides insight into its chemical behavior and potential applications. This compound is a member of the pyrazolone class and exhibits interesting solubility characteristics:

  • Solvent Dependency: The solubility can vary significantly depending on the solvent used. Generally, compounds with similar functional groups tend to have higher solubility in organic solvents.
  • Polar vs. Non-Polar Solvents:
    • It is expected to be more soluble in non-polar solvents, due to its hydrophobic isopropyl and phenyl groups.
    • In polar solvents, such as water, solubility may be lower due to the absence of highly polar functional groups.
  • Temperature Influence: Like many organic compounds, solubility may increase with temperature, enabling better dissolution in higher-energy environments.

Understanding the solubility profile of this compound is crucial for its utilization in various applications, including pharmaceuticals and materials science. As a general note, predicting solubility trends can often be challenging without empirical data, but the structural features of 4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one can guide one’s expectations.

Interesting facts

Interesting Facts about 4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one

4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one is a fascinating compound that belongs to the family of pyrazolones, a group known for their significant biological activities. Here are some captivating insights about this compound:

  • Pharmaceutical Potential: Compounds like 4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one have garnered attention for their potential use in medicinal chemistry. Their structure enables them to act on various biological targets, leading to applications in anti-inflammatory and analgesic therapies.
  • Synthetic Versatility: The synthesis of pyrazolones often involves multi-step approaches. This compound showcases the ability of chemists to manipulate molecular structures to enhance desired properties. Techniques such as condensation reactions are key in creating these complex molecules.
  • Pharmacophore: The unique arrangement of functional groups in this compound represents a significant pharmacophore, which is crucial in drug design. The presence of both aromatic and aliphatic groups increases the likelihood of interaction with biological systems.
  • Structure-Activity Relationship (SAR): Scientists often study compounds like this one to establish a structure-activity relationship. By systematically altering specific molecular components, researchers can optimize efficacy while minimizing adverse effects, paving the way for novel therapeutic agents.
  • Scientific Interest: This compound serves as a subject of interest in various fields including organic chemistry, medicinal chemistry, and drug development. Its multifaceted nature opens up avenues for research that may lead to groundbreaking discoveries.

As we delve into the chemistry of 4-isopropyl-1,5-dimethyl-2-phenyl-pyrazol-3-one, we are reminded of the intricate dance between structure and function that defines the essence of many bioactive compounds. Exploring its potential not only broadens our understanding of chemical interactions but also brings us closer to advancements in health and medicine.

Synonyms
Propyphenazone
479-92-5
isopropylantipyrine
4-Isopropylantipyrine
Isopropylphenazone
Isopropyrine
Isopropylantipyrin
Propifenazona
Larodon
Isopropylantipyrinum
Propyphenazonum
Propifenazone
Yoshipyrin
1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one
1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one
Budirol
Cibalgina
Propifenazone [DCIT]
1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one
Propifenazona [INN-Spanish]
Propyphenazonum [INN-Latin]
Propyphenazon
CCRIS 6716
4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Propyphenazone [INN:BAN:DCF]
ANTIPYRINE, 4-ISOPROPYL-
CHEBI:135538
OED8FV75PY
Yoshipyrin (TN)
EINECS 207-539-2
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-
BRN 0204533
4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one
DTXSID6023529
Propyphenazone (INN)
2,3-Dimethyl-4-isopropyl-1-phenyl-3H-pyrazolin-5-one
3-Pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl-
3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-
PROPYPHENAZONE [MI]
5-Pyrazolone, 1-phenyl-2,3-dimethyl-4-isopropyl-
PROPYPHENAZONE [INN]
PROPYPHENAZONE [MART.]
DTXCID503529
PROPYPHENAZONE [WHO-DD]
ISOPROPYLANTIPYRINE [JAN]
4-Isopropyl-2,3-dimethyl-1-phenyl-5-pyrazolone
1,5-dimethyl-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3H-pyrazol-3-one
5-24-01-00408 (Beilstein Handbook Reference)
PROPYPHENAZONE [EP MONOGRAPH]
4-Isopropylantipyrine;Isopropylphenazone
NCGC00164612-01
Isopropchin
1,5-dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
Propifenazona (INN-Spanish)
Propyphenazonum (INN-Latin)
PROPYPHENAZONE (MART.)
4-Isopropyl-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
Causyth
PROPYPHENAZONE (EP MONOGRAPH)
Isopropyl Phenazone
CAS-479-92-5
4-Isopropylphenazone
UNII-OED8FV75PY
Propyphenazone,(S)
MFCD00053368
4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one
Propyphenazone (Standard)
ChemDiv2_002457
Epitope ID:124928
Isopropylantipyrine (JP17)
Isopropylantipyrine (JP18)
SCHEMBL23393
MLS004773970
CHEMBL28318
HY-A0273R
PXWLVJLKJGVOKE-UHFFFAOYSA-
N02BB04
HMS1375P15
HY-A0273
Tox21_112233
s5309
STK766727
AKOS001725335
Propyphenazone (4-Isopropylantipyrine)
Tox21_112233_1
CCG-266797
CS-5533
DB13524
FP67039
NCGC00164612-02
AC-12099
BS-16890
Propyphenazone 1.0 mg/ml in Acetonitrile
SMR001495368
I0656
NS00010501
D01380
D91192
Q425111
SR-01000536454
4-Isopropylantipyrine, analytical reference material
SR-01000536454-1
4-ISOPROPYL-1,5-DIMETHYL-2-PHENYL-3-PYRAZOLONE
Propyphenazone, European Pharmacopoeia (EP) Reference Standard
4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one #
pyrazole, 2,3-dihydro-4-isopropyl-1,5-dimethyl-3-oxo-2-phenyl-
Propyphenazone, Pharmaceutical Secondary Standard; Certified Reference Material
207-539-2
InChI=1/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3