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Aminophenazone

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Identification
Molecular formula
C13H17N3O
CAS number
58-15-1
IUPAC name
4-isopropyl-1-methyl-5-[[methyl-(1-methyl-2-phenyl-ethyl)amino]methyl]-2-phenyl-pyrazol-3-one
State
State

At room temperature, aminophenazone exists as a solid. It tends to be stable under normal conditions, although it should be handled carefully to avoid inhalation or ingestion.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
245.00
Boiling point (Kelvin)
518.15
General information
Molecular weight
231.30g/mol
Molar mass
231.2960g/mol
Density
1.1240g/cm3
Appearence

Aminophenazone appears as a white or slightly yellowish crystalline powder. It is relatively stable and possesses a sharp melting point.

Comment on solubility

Solubility of 4-isopropyl-1-methyl-5-[[methyl-(1-methyl-2-phenyl-ethyl)amino]methyl]-2-phenyl-pyrazol-3-one

When evaluating the solubility of the compound 4-isopropyl-1-methyl-5-[[methyl-(1-methyl-2-phenyl-ethyl)amino]methyl]-2-phenyl-pyrazol-3-one (C13H17N3O), there are several factors to consider:

  • Polarity: The presence of nitrogen and oxygen atoms suggests potential polar characteristics, which can enhance solubility in polar solvents.
  • Hydrophobic Regions: The isopropyl and phenyl groups contribute to a hydrophobic nature, which may decrease solubility in water, favoring organic solvents.
  • Functional Groups: The amine group may allow for hydrogen bonding, possibly improving solubility in certain conditions.
  • Temperature and pH: Solubility can vary significantly with changes in temperature and the pH of the environment.

In general, compounds with similar structures tend to show variable solubility depending on their environment. While there is a potential for moderate solubility in polar solvents due to functional groups, the overall behavior in mixtures or different solutions may diverge. It's essential to conduct experimental measurements under specific conditions to accurately determine solubility in applicable solvents.

As with many chemical compounds, solubility is a complex characteristic influenced by multifaceted interactions.

Interesting facts

Interesting Facts about 4-isopropyl-1-methyl-5-[[methyl-(1-methyl-2-phenyl-ethyl)amino]methyl]-2-phenyl-pyrazol-3-one

This compound is a member of the extensive pyrazolone family, which are known for their diverse biological activities. Its complex structure showcases various functional groups that enhance its interaction with biological systems, making it a subject of numerous studies.

Key Features:

  • Bioactivity: Compounds in the pyrazolone category, particularly this one, have been explored for their potential anti-inflammatory and analgesic properties.
  • Structural Diversity: The presence of multiple aryl and alkyl substituents provides a unique arrangement that may influence its reactivity and pharmacological properties.
  • Synthetic Pathways: This compound highlights the importance of synthetic organic chemistry, as the intricate synthesis provides a deep insight into the mechanisms of chemical transformations.

As a scientist or student delving into the world of medicinal chemistry, you'll find this compound fascinating not just for its structure but also for its implications in drug discovery. The combination of amino and phenyl groups suggests that it may serve as a scaffold for developing new therapeutic agents.

Moreover, compounds like this emphasize the importance of structure-activity relationships (SAR) in medicinal chemistry, where slight changes in chemical structure can lead to significant differences in activity:

"Understanding the nuances of molecular interactions opens the door to designing better drugs."

Overall, 4-isopropyl-1-methyl-5-[[methyl-(1-methyl-2-phenyl-ethyl)amino]methyl]-2-phenyl-pyrazol-3-one represents not only a fascinating chemical entity but also a bridge to deeper explorations in chemical biology and pharmacology.

Synonyms
Famprofazone
22881-35-2
Famprofazonum
Famprofazona
Famprofazon
Geodowin
Famprofazone [INN:BAN]
Famprofazonum [INN-Latin]
Famprofazona [INN-Spanish]
3H-Pyrazol-3-one, 1,2-dihydro-1-methyl-4-(1-methylethyl)-5-[[methyl(1-methyl-2-phenylethyl)amino]methyl]-2-phenyl-
UNII-HN0NCX453C
EINECS 245-284-9
HN0NCX453C
NSC-759244
BRN 5768367
DTXSID3045435
FAMPROFAZONE [INN]
FAMPROFAZONE [MART.]
FAMPROFAZONE [WHO-DD]
1-methyl-5-[[methyl(1-phenylpropan-2-yl)amino]methyl]-2-phenyl-4-propan-2-ylpyrazol-3-one
DTXCID1025435
component of Gewodin (Salt/Mix)
Antipyrine, 4-isopropyl-3-(alpha-(methyl-(1-phenyl-2-propyl)amino))-
3-(N-Methyl-(alpha-methyl-beta-phenyl)-ethyl-aminomethyl)-4-isopropyl-norantipyrine [French]
Pyrazolin-5-one, 4-isopropyl-2-methyl-1-phenyl-3-((1-phenyl-2-propyl)methylamino)methyl-
NSC 759244
1,2-Dihydro-1-methyl-4-(1-methylethyl)-5-((methyl(1-methyl-2-phenylethyl)amino)methyl)-2-phenyl-3H-pyrazol-3-one
3H-Pyrazolin-5-one, 4-isopropyl-2-methyl-3-((methyl(alpha-methylphenethyl)amino)methyl)-1-phenyl-
Famprofazonum (INN-Latin)
Famprofazona (INN-Spanish)
3-(N-Methyl-(alpha-methyl-beta-phenyl)-ethyl-aminomethyl)-4-isopropyl-norantipyrine
FAMPROFAZONE (MART.)
3H-Pyrazol-3-one, 1,2-dihydro-1-methyl-4-(1-methylethyl)-5-((methyl(1-methyl-2-phenylethyl)amino)methyl)-2-phenyl-
Antipyrine, 4-isopropyl-3-(.alpha.-(methyl-(1-phenyl-2-propyl)amino))-
3-(N,.alpha.-Dimethylphenethylaminomethyl)-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-one
3-(N-Methyl-(.alpha.-methyl-.beta.-phenyl)-ethyl-aminomethyl)-4-isopropyl-norantipyrine
1,2-Dihydro-1-methyl-4-(1-methylethyl)-5-[[methyl(1-methyl-2-phenylethyl)amino]methyl]-2-phenyl-3H-pyrazol-3-one
1-methyl-5-{[methyl(1-phenylpropan-2-yl)amino]methyl}-2-phenyl-4-(propan-2-yl)-2,3-dihydro-1H-pyrazol-3-one
4-isopropyl-1-methyl-5-((methyl(1-phenylpropan-2-yl)amino)methyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
4-ISOPROPYL-2-METHYL-3-((METHYL(.ALPHA.-METHYLPHENETHYL)AMINO)METHYL)-1-PHENYL-3-PYRAZOLIN-5-ONE
4-Isopropyl-2-methyl-3-([methyl(.alpha.-methylphenethyl)amino]methyl)-1-phenyl-3-pyrazolin-5-one
4-Isopropyl-2-methyl-3-{(methyl(alpha-methylphenethyl)amino)methyl}-1-phenyl-3-pyrazolin-5-one
SR-01000838884
NCGC00016769-01
1-methyl-5-((methyl(1-phenylpropan-2-yl)amino)methyl)-2-phenyl-4-(propan-2-yl)-2,3-dihydro-1H-pyrazol-3-one
3H-Pyrazol-3-one, 1,2-dihydro-1-methyl-4-(1-methylethyl)-5-[[methyl(1-methyl-2-phenylethyl)amino]methyl]-2-phenyl-; Famprofazone; 3-Pyrazolin-5-one, 4-isopropyl-2-methyl-3-[[methyl(alpha-methylphenethyl)amino]methyl]-1-phenyl- (8CI)
4-ISOPROPYL-2-METHYL-3-((METHYL(ALPHA-METHYLPHENETHYL)AMINO)METHYL)-1-PHENYL-3-PYRAZOLIN-5-ONE
CAS-22881-35-2
Prestwick0_000703
Prestwick1_000703
Prestwick2_000703
Prestwick3_000703
BSPBio_000885
MLS002153964
SCHEMBL893453
SPBio_002806
BPBio1_000975
CHEMBL1475693
CHEBI:93799
Famprofazone, analytical standard
GLXC-20247
HMS1570M07
HMS2097M07
HMS2235J18
HMS3369C14
HMS3714M07
Pharmakon1600-01505773
HY-B1054
Famprofazone 1.0 mg/ml in Methanol
Tox21_110600
BDBM50103614
NSC602800
NSC759244
AKOS015894771
Tox21_110600_1
CCG-213983
CS-4576
KS-1356
NSC-602800
NCGC00179385-01
NCGC00179385-03
4-Isopropyl-2-methyl-3- (methyl(alpha-methylphenethyl)amino)methyl -1-phenyl-3-pyrazolin-5-one
4-isopropyl-2-methyl-3-(N-methyl-N-(alpha-methylphenylethyl)aminomethyl)-1-phenyl-3-pyrazolin-5-one
SMR001233303
SBI-0207052.P001
AB00513898
NS00003719
SW196346-3
AB00513898_06
AB00513898_07
Q5433492
SR-01000838884-2
SR-01000838884-3
BRD-A08255417-001-03-0
BRD-A08255417-001-06-3
BRD-A08255417-001-13-9
BRD-A08255417-001-14-7
3-(N,alpha-Dimethylphenethylaminomethyl)-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-one
245-284-9