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4-Iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)benzamide

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Identification
Molecular formula
C24H28IN3O2
CAS number
202743-54-8
IUPAC name
4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)benzamide
State
State

At room temperature, the compound is typically in a solid state.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.20
Boiling point (Celsius)
511.50
Boiling point (Kelvin)
784.70
General information
Molecular weight
532.52g/mol
Molar mass
532.5210g/mol
Density
1.4047g/cm3
Appearence

The compound appears as a crystalline solid, typically in a pale yellow to off-white form. It is not highly soluble in water but may be soluble in organic solvents such as methanol or ethanol.

Comment on solubility

Solubility of 4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)benzamide

The solubility of the compound C24H28IN3O2 can be discussed in several contexts, particularly considering its molecular structure and the presence of various functional groups. Solubility is influenced by several key factors:

  • Polarity: The presence of the pyridyl and piperazine groups tends to increase polarity, which can enhance solubility in polar solvents like water.
  • Hydrophobic Interactions: The methoxyphenyl and iodine substituents may impart hydrophobic characteristics, potentially reducing solubility in aqueous environments.
  • Solvent Compatibility: This compound may be more soluble in organic solvents such as ethanol or DMSO due to its extensive hydrophobic regions.

It is essential to note that:

  • The solubility can vary widely based on the concentration of the solution and temperature.
  • Crystallization: Some compounds like this may have limited solubility at room temperature but can dissolve better when heated.

In summary, while the solubility of 4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)benzamide is likely to be moderate in polar solvents, specific experimental conditions will ultimately determine its solubility profile. Further experimental validation will provide clarity on its practical usability in various applications.

Interesting facts

Exploring 4-Iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)benzamide

This complex compound, known as 4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)benzamide, is an interesting study for medicinal chemists and pharmacologists alike. Its intricate structure suggests potential biological activity, making it a candidate for various therapeutic applications.

Key Features and Potential Applications

  • Diverse Functional Groups: The presence of a piperazine moiety, an aromatic ether group, and a pyridine ring contributes to its versatility in binding interactions within biological systems.
  • Targeting Neurological Disorders: Similar compounds have been explored for their affinities to specific receptors in the brain, making them attractive for research in the context of treating conditions like depression, anxiety, or schizophrenia.
  • Halogen Influence: The iodo substituent can enhance lipophilicity and biological activity, aiding in receptor binding and improving pharmacokinetic properties.
  • Drug Development Potential: Compounds with similar structures have undergone clinical trials, showcasing the relevance of such compounds in developing new medications.

As researchers delve into the synthesis and evaluation of this compound, it's noteworthy that the design of multifunctional agents could lead to innovative therapies. In the words of a renowned chemist, “The best discoveries arise from the chemical imagination, merging structure with function.” This highlights the promise that 4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)benzamide holds in the field of drug design.

In summary, studying this compound not only enhances our understanding of chemical interactions but also paves the way for advances in treating complex diseases. The journey from molecular structure to therapeutic efficacy is a fascinating aspect of chemical and biological sciences!

Synonyms
p-MPPI
155204-23-2
4-Mppi
4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide
4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine
4-iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-benzamide hydrochloride
CHEMBL29027
DTXSID70165857
4-Iodo-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinylbenzamide
4-Iodo-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)benzamide
Benzamide, 4-iodo-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinyl-
4-Iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)benzamide
4-Iodo-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-N-pyridin-2-yl-benzamide
4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-pyridin-2-ylbenzamide
4-IODO-N-(2-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-ETHYL)-N-PYRIDIN-2-YL-BENZAMIDE
4-Iodo-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylbenzamide
NCGC00015638-01
Lopac-M-204
GTPL68
Lopac0_000874
SCHEMBL2640211
DTXCID9088348
FGA20423
BDBM50035508
MFCD10565910
CCG-204956
SDCCGSBI-0050849.P002
NCGC00015638-02
SY288488
E86171
L001337
Q27078091
4-iodo-n-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-benzamide