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4-Hydroxybenzohydrazide

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Identification
Molecular formula
C7H8N2O2
CAS number
1571-75-1
IUPAC name
4-hydroxybenzohydrazide
State
State

At room temperature, 4-Hydroxybenzohydrazide is in a solid state. Its stability as a crystalline powder makes it easy to handle and store under standard conditions.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
312.00
Boiling point (Kelvin)
585.15
General information
Molecular weight
152.15g/mol
Molar mass
152.1550g/mol
Density
1.3960g/cm3
Appearence

4-Hydroxybenzohydrazide typically appears as a white to off-white crystalline powder. It is a solid compound and is noted for its purity and consistency, making it useful in various chemical applications.

Comment on solubility

Solubility of 4-hydroxybenzohydrazide (C7H8N2O2)

4-hydroxybenzohydrazide exhibits interesting solubility characteristics that are influenced by its chemical structure. This compound, featuring both hydrazide and hydroxyl functional groups, demonstrates varying solubility behaviors depending on the solvent.

Solubility Characteristics

  • Water Solubility: 4-hydroxybenzohydrazide is generally soluble in water, thanks to its hydrophilic hydroxyl group.
  • Organic Solvents: The compound tends to be soluble in organic solvents such as methanol and ethanol, owing to the compatibility of the hydrophobic aromatic ring with non-polar solvents.
  • Temperature Dependence: Solubility may increase with temperature, making it easier to dissolve in hot solvents.

In summary, while 4-hydroxybenzohydrazide is soluble in both water and various organic solvents, its solubility can be influenced by factors such as temperature and the nature of the solvent used. As with many compounds, understanding these solubility nuances can be crucial for applications in synthesis and formulation.

Interesting facts

Interesting Facts about 4-Hydroxybenzohydrazide

4-Hydroxybenzohydrazide is an intriguing compound often explored for its applications in various fields, particularly in organic chemistry and medicinal chemistry. Here are some fascinating aspects of this compound:

  • Structural Features: This compound incorporates a hydrazine functional group attached to a hydroxybenzoic acid moiety, leading to unique reactivity patterns. The presence of the hydroxyl group enhances its solubility in polar solvents and can influence the compound's biological activity.
  • Applications in Synthesis: 4-Hydroxybenzohydrazide is utilized as a key intermediate in synthesizing various pharmaceuticals. Its ability to form hydrazones has made it valuable in the synthesis of other complex organic molecules, including those used in drug development.
  • Biological Research: Researchers have studied this compound for its potential antitumor properties. Various derivatives have shown promising results in biological assays, suggesting that modifications to the 4-hydroxybenzohydrazide framework could enhance its efficacy and reduce toxicity.
  • Analytical Use: This compound can serve as a reagent in analytical chemistry, particularly in colorimetric methods for detecting certain metal ions, showcasing its utility beyond just organic synthesis.

As chemists delve deeper into the functionalities of 4-hydroxybenzohydrazide, they inspire potential new pathways for drug design and development. Indeed, understanding the chemistry behind such compounds can lead to novel therapeutic agents that may one day improve health outcomes. Emphasizing innovation and exploration fosters curiosity in the world of chemistry!

Synonyms
4-hydroxybenzhydrazide
4-Hydroxybenzohydrazide
5351-23-5
4-Hydroxybenzoic acid hydrazide
4-Hydroxybenzoic hydrazide
4-Hydroxybenzoylhydrazine
p-Hydroxybenzhydrazide
p-Hydroxybenzoic acid hydrazide
Benzoic acid, 4-hydroxy-, hydrazide
(p-Hydroxybenzoyl)hydrazine
p-Hydroxybenzoic hydrazide
Benzoic acid, p-hydroxy-, hydrazide
4-Hydroxy-benzoic acid hydrazide
NSC 647
para-Hydroxybenzoic acid hydrazide
(4-Hydroxybenzoyl)hydrazine
Y4G7G6U5GQ
MFCD00007605
NSC-647
4-Oxidanylbenzohydrazide
p-hydroxybenzoylhydrazine
EINECS 226-326-5
p-Hydroxybenzoyl hydrazide
CHEMBL124267
DTXSID90201721
4-Hydroxybenzohydrazide (p-Hydroxybenzohydrazide)
benzoylhydrazine, P-hydroxy
4-Hydroxybenzohydrazide; Nifuroxazide Imp. A (EP); p-Hydroxybenzohydrazide; Nifuroxazide Impurity A
p-hydroxybenzohydrazide
4OHPhCON2
4-hydroxy-benzohydrazide
4-hydroxybenzo hydrazide
Lopac-H-9882
4-hydroxybenzoyl hydrazide
4-hydroxybenzoate hydrazide
UNII-Y4G7G6U5GQ
Lopac0_000568
Oprea1_145739
SCHEMBL80530
MLS002153529
NSC647
4-Hydroxybenzhydrazide, >=97%
4-Hydroxybenzoic acid, hydrazide
DTXCID20124212
CHEBI:195425
HMS3062I15
HMS3261B18
ALBB-001058
Tox21_500568
BBL008415
BDBM50320734
STK076141
AKOS000119735
BS-3839
CCG-204657
CS-W013295
FH54889
LP00568
SDCCGSBI-0050550.P002
NCGC00015528-01
NCGC00015528-02
NCGC00015528-03
NCGC00015528-04
NCGC00015528-05
NCGC00093952-01
NCGC00093952-02
NCGC00261253-01
PD015118
SMR000247649
SY009530
DB-052349
Benzoic acid, 4-hydroxy-, hydrazide (9CI)
Benzoic acid, p-hydroxy-, hydrazide (8CI)
EU-0100568
H1275
NS00032777
EN300-17785
H 9882
SR-01000075923
SR-01000075923-1
p-Hydroxybenzhydrazide;4-Hydroxybenzoic acid hydrazide
Z57036327
4-Hydroxybenzhydrazide, suitable for fluorescence, >=97.0% (T)
226-326-5