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Podophyllotoxin

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Identification
Molecular formula
C22H22O8
CAS number
518-28-5
IUPAC name
4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one
State
State

Podophyllotoxin is typically in a solid state at room temperature. It is stable under normal conditions and should be handled with care as it is a biologically active compound.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
655.00
Boiling point (Kelvin)
928.15
General information
Molecular weight
414.41g/mol
Molar mass
414.4130g/mol
Density
2.2800g/cm3
Appearence

Podophyllotoxin is a naturally occurring plant-derived compound that usually appears as a white to off-white crystalline powder. It can be transparent or exhibit a subtle sheen due to its crystalline nature.

Comment on solubility

Solubility of 4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one

The solubility characteristics of the compound C22H22O8 (4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one) are crucial for its potential applications in various fields. Here are some key points about its solubility:

  • Polarity: The presence of multiple hydroxyl (-OH) and methoxy (-OCH3) groups suggests that the compound may exhibit varying levels of solubility in polar solvents, such as water.
  • Non-polar Solvents: Given its large polycyclic structure, the compound may also be soluble in non-polar organic solvents such as dichloromethane or ethyl acetate.
  • Hydrogen Bonding: The hydroxyl groups can form hydrogen bonds, potentially enhancing solubility in polar media.
  • Temperature Dependence: The solubility of such complex organic compounds is often temperature dependent; higher temperatures might improve solubility in solvents.

In essence, while this compound may show some degree of solubility in both polar and non-polar solvents, the exact solubility needs to be confirmed through experimental data to understand its behavior in various conditions. As a general rule, solubility can be influenced by structure and environmental factors, making it a fascinating subject for further investigation.

Interesting facts

Interesting Facts About 4-Hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one

This intriguing compound, known for its complex structure and potential applications, boasts several noteworthy features that capture the interest of chemists and researchers alike:

  • Chemical Structure: Its elaborate structure includes multiple functional groups, particularly hydroxyl and methoxy groups, which significantly influence its chemical behavior and biological activity.
  • Potential Biological Activity: Compounds similar to this one have been investigated for their anti-inflammatory and antioxidant properties, making them candidates for pharmaceutical research.
  • Natural Occurrence: Many compounds in the same family are derived from plants, leading to inquiries about their natural sources and the ecological roles they play.
  • Research Applications: Scientists are exploring this compound for use in materials science, specifically in quarterly to polymer chemistry.
  • Synthesis Challenges: The synthesis of such complex organic molecules can be challenging, often requiring multi-step procedures and refined techniques in organic synthesis.

As chemists study compounds like this, they contribute invaluable insight into both basic science and applied research.
The detailed exploration of their properties helps pave the way for innovations in health, materials, and environmental science.

In conclusion, 4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one stands as a testament to the intricate interplay of structure and function in chemistry, inspiring both scholarly investigation and practical applications.

Synonyms
299431-00-8
MLS002702982
NSC659372
SCHEMBL516628
CHEMBL1435754
DTXSID00871732
HLBPOYVRLSXWJJ-UHFFFAOYSA-N
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-10-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5.alpha.,5a.beta.,8a.alpha.)]-
AKOS024322664
NCGC00095966-01
NCGC00095966-02
10-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
SMR001566792
10-HO-5-(3,4,5-TRI-MEO-PH)-4H-5AH-FURO(3',4':6,7)NAPHTHO(2,3-D)(1,3)DIOXOL-6-ONE
10-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one #
4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one
5,8,8a,9-Tetrahydro-10-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3a(2),4a(2):6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Naphtho(2,3-d)-1,3-dioxole-6-carboxylic acid, 5,6,7,8-tetrahydro-9-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-, .gamma.-lactone
NCGC00095966-03!4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one