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Kojic acid

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Identification
Molecular formula
C6H6O4
CAS number
501-30-4
IUPAC name
4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one
State
State

At room temperature, kojic acid is a solid. It is typically found in powder form, which is convenient for use in various applications, particularly in skincare formulations.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
292.00
Boiling point (Kelvin)
565.15
General information
Molecular weight
142.11g/mol
Molar mass
142.1130g/mol
Density
1.5809g/cm3
Appearence

Kojic acid is usually seen as a white to slightly yellow powder. It can also appear in the form of crystals. Kojic acid easily dissolves in water, alcohol, and acetone, making it versatile in its applications, especially in cosmetic products.

Comment on solubility

Solubility of 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one (C6H6O4)

The solubility of 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one, a compound with the chemical formula C6H6O4, can be influenced by various factors. Understanding its solubility characteristics is crucial for its potential applications and efficacy in different environments. Here are some key points to consider:

  • Polarity: The presence of hydroxyl functional groups in its structure suggests that 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one may exhibit enhanced solubility in polar solvents such as water. This is due to the ability of hydroxyl groups to form hydrogen bonds with solvent molecules.
  • Solvent Interaction: The solubility is also dependent on the solvent used for dissolution. In non-polar solvents, this compound may show limited solubility due to its polar nature.
  • Temperature: Increasing temperature typically increases the solubility of solids in liquids; thus, heating the solution may enhance the solubility of this compound considerably.
  • pH Influence: Solubility can vary with pH; hence, alterations in the acidity or basicity of the solution might significantly affect the dissolution behavior of the compound.

In summary, while 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one is expected to be soluble in aqueous solutions, particularly at higher temperatures and in varying pH conditions, its solubility in non-polar environments is likely to be much lower. As always, experimental validation is essential to determine the exact solubility profile in different conditions.

Interesting facts

Interesting Facts About 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one

4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one is a fascinating compound that showcases the intricate beauty of organic chemistry. This versatile molecule is primarily known for its presence in a variety of natural products and can be derived from more complex biochemicals. Here are some noteworthy aspects of this compound:

  • Natural Occurrence: This compound can be found in nature, particularly in certain plants where it contributes to the overall profile of phytochemicals. Its existence in plant metabolites underscores its ecological importance.
  • Structural Complexity: The unique structural features of 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one, including its fused ring system, not only enhance its stability but also influence its reactivity in organic reactions.
  • Reactivity: This compound exhibits notable reactivity due to the presence of functional groups. It can participate in various chemical transformations, making it a valuable compound in synthetic organic chemistry.
  • Potential Applications: Researchers are interested in its potential applications in pharmaceuticals and materials science, given its unique properties. Its role in the synthesis of biologically active compounds is an area of ongoing research.
  • Scientific Significance: The study of such compounds helps chemists understand the challenges of stereochemistry and functionalization in organic synthesis, furthering the development of new methodologies and reactions.

In conclusion, 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one is more than just a simple compound; it is a testament to the intricacies of molecular structure and reactivity that define the field of chemistry. Its significant presence in nature, along with its potential for application, makes it an exciting subject of study for chemists and students alike.

Synonyms
patulin
149-29-1
Clavacin
Clavatin
Expansin
Patuline
Expansine
Claviform
Claviformin
Clairformin
Leucopin
Terinin
Gigantin
Mycoin
Mycoin C3
Penicidin
Tercinin
Mycoine C3
Mycosin
Penatin
Mycoin C
4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
4H-Furo[3,2-c]pyran-2(6H)-one, 4-hydroxy-
4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one
NSC 8120
NSC 32951
Sch-351633
4-Hydroxy-4H-furo(3,2-C)pyran-2(6H)-one
CCRIS 4940
Clavicin
Clavitin
Expansion
HSDB 3522
Gigantic acid?
4,6-Dihydro-4-hydroxy-2H-furo(3,2-c)pyran-2-one
(2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid, 3,4-lactone
EINECS 205-735-2
UNII-95X2BV4W8R
MFCD00005858
SCH 351633
4H-Furo(3,2-c)pyran-2(6H)-one, 4-hydroxy-
BRN 0149675
95X2BV4W8R
(2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid-3,4-lactone
CHEBI:74926
DL-PATULIN
NSC8120
Acetic acid, (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone
Antibiotic YS 1649
NSC-8120
NSC32951
PATULIN [HSDB]
PATULIN [IARC]
PATULIN [MI]
NSC-32951
4H-Furo(3,3-c)pyran-2(6H)-one, 4-hydroxy-
Antibiotic Sch 351633
4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-one
CHEMBL294018
DTXSID2021101
4-Hydroxy-4,6-dihydrofuro[4,5-c]pyran-2-one
2,4-Dihydroxy-2H-pyran-delta-3(6H),alpha-acetic acid-3,4-lactone
5-18-03-00005 (Beilstein Handbook Reference)
2H-Pyran-delta(sup 3(6H),alpha)-acetic acid, 2,4-dihydroxy-, 3,4-lactone
Patulin 100 microg/mL in Acetonitrile
YS 1649
PATULIN (IARC)
(2, 3,4-lactone
4-Hydroxy-4H-Furo(3,3-c)pyran-2(6H)-one
4-hydroxy-2H,4H,6H-furo[3,2-c]pyran-2-one
4H-Furo[3, 4-hydroxy-
247172-18-5
4-hydroxy-4,6-dihydro-2H-furo[3,2-c]pyran-2-one
4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one, 9CI, 8CI
(+/-)-4-HYDROXY-4H-FURO(3,2-C)PYRAN-2(6H)-ONE
2,.alpha.-acetic acid, 3,4-lactone
2,4-Dihydroxy-2H-pyran-.delta.-3(6H),.alpha.-acetic acid, 3,4-lactone
2H-Pyran-.delta.(3(6H),.alpha.)-acetic acid, 2,4-dihydroxy-,3,4-lactone
WLN: T56 BOV GO IU & TJ FQ
4-hydroxy-2H,4H,6H-furo(3,2-c)pyran-2-one
4-hydroxy-4,6-dihydrofuro(3,2-c)pyran-2-one
4-Hydroxy-4,6-dihydrofuro(4,5-c)pyran-2-one
SR-05000002238
4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one, 9CI, 8CI
2H-Pyran-.delta.(sup 3(6H), 2,4-dihydroxy-, 3,4-lactone
Acetic acid,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone
Clavacin; Expansin
Patulin (Standard)
520 - Patulin
Spectrum_000015
starbld0009637
Spectrum3_000796
Spectrum4_000753
Spectrum5_001659
PATULIN 13C3
Patulin, reference material
Neuro_000008
Clairformin;Patuline;Clavatin
SCHEMBL29056
BSPBio_002532
KBioGR_001106
KBioSS_000355
DivK1c_000438
SPECTRUM1503904
DTXCID701101
MEGxm0_000442
ACon1_002106
HMS501F20
HY-N6779R
KBio1_000438
KBio2_000355
KBio2_002923
KBio2_005491
KBio3_001752
Patulin from Penicillium expansum
MSK7008
NINDS_000438
HMS1923M19
Patulin, >=98.0% (HPLC)
BCP29227
EX-A5478
HY-N6779
YEB13369
BDBM50158841
MSK7008-100A
SCH351633
4Hydroxy4Hfuro(3,2c)pyran2(6H)one
AKOS015904103
BS-1260
CCG-208451
DB15586
FP31796
IDI1_000438
SMP1_000230
NCGC00095272-01
NCGC00095272-02
NCGC00095272-03
NCGC00095272-04
NCGC00095272-05
NCI60_041782
4,6Dihydro4hydroxy2Hfuro(3,2c)pyran2one
DB-042987
4-Hydroxy-4H,6H-furo[3,2-c]pyran-2-one
CS-0083018
NS00011821
Patulin Solution in Acetonitrile, 100ug/mL
A12069
Q414526
SR-05000002238-2
SR-05000002238-3
(2,4Dihydroxy2Hpyran3(6H)ylidene)acetic acid3,4lactone
(2,4Dihydroxy2Hpyran3(6H)ylidene)acetic acid, 3,4lactone
2,4-Dihydroxy-2H-pyran-alpha -acetic acid, 3, 4-lactone
2,4-Dihydroxy-2H-pyran-alpha-acetic acid, 3, 4-lactone
2,4Dihydroxy2Hpyrandelta3(6H),alphaacetic acid3,4lactone
2H-Pyran-alpha)-acetic acid, 2, 4-dihydroxy-,3,4-lactone
2H-Pyran-alpha)-acetic acid, 2,4-dihydroxy-, 3,4-lactone
(2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetate, 3,4-lactone
(2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetate-3,4-lactone
2H-Pyran-.delta.(sup 3(6H), 2,4-dihydroxy-,3,4-lactone
2H-Pyran-alpha )-acetic acid, 2, 4-dihydroxy-,3,4-lactone
2H-Pyran-alpha )-acetic acid, 2,4-dihydroxy-, 3,4-lactone
Acetic acid, (2,4dihydroxy2Hpyran3(6H)ylidene), 3,4lactone
2,4-Dihydroxy-2H-pyran-delta-3(6H),alpha-acetic acid, 3,4-lactone
2H-Pyran-delta(3(6H),alpha)-acetic acid, 2,4-dihydroxy-,3,4-lactone
2HPyrandelta(sup 3(6H),alpha)acetic acid, 2,4dihydroxy, 3,4lactone