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Apixaban

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Identification
Molecular formula
C25H25N5O4S
CAS number
503612-47-3
IUPAC name
4-hydroxy-3-[[2-oxo-3-(thieno[3,2-b]pyridin-2-ylsulfonylamino)pyrrolidin-1-yl]methyl]benzamidine
State
State

Apixaban is in a solid state at room temperature. It is typically available as a crystalline powder and is formulated into tablets for pharmaceutical use.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.00
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.00
General information
Molecular weight
459.48g/mol
Molar mass
459.4770g/mol
Density
1.4000g/cm3
Appearence

Apixaban is typically a crystalline solid. It is usually found in its salt forms which are often white to off-white powders. It does not have a notable color or odor when pure.

Comment on solubility

Solubility of 4-hydroxy-3-[[2-oxo-3-(thieno[3,2-b]pyridin-2-ylsulfonylamino)pyrrolidin-1-yl]methyl]benzamidine

The solubility of the compound C25H25N5O4S, also known as 4-hydroxy-3-[[2-oxo-3-(thieno[3,2-b]pyridin-2-ylsulfonylamino)pyrrolidin-1-yl]methyl]benzamidine, can provide insight into its potential applications, bioavailability, and suitability for pharmaceutical formulations.

Key Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl and sulfonamide groups enhances the polarity of the compound, which generally increases solubility in polar solvents, such as water.
  • Molecular Weight: With a molecular weight of 485.56 g/mol, larger compounds can demonstrate reduced solubility; however, functional groups can offset this.
  • pH Sensitivity: The solubility may vary with pH, as amines and sulfonamides can exist in charged or neutral forms, impacting their interaction with solvents.

Moreover, the specific structural features, like the thieno[3,2-b]pyridin moiety, may lead to unique solubility characteristics, including:

  • Non-polar Characteristics: Parts of the molecule that are aromatic or heterocyclic may hinder water solubility.
  • Hydrogen Bonding: The potential for intramolecular and intermolecular hydrogen bonding can also play a role in solubility behaviors.

In summary, while predicting the exact solubility of this complex compound may require empirical testing, the outlined considerations provide a structured approach to understanding its solubility profile in various environments.

Interesting facts

4-Hydroxy-3-[[2-oxo-3-(thieno[3,2-b]pyridin-2-ylsulfonylamino)pyrrolidin-1-yl]methyl]benzamidine

This compound, known for its complex structure, falls into the category of bioactive molecules that are often explored for pharmaceutical applications. Its unique configuration exemplifies the intricate nature of medicinal chemistry, where every atom and functional group plays a critical role in the compound's biological activity.

Key Characteristics:

  • Structural Complexity: The presence of thieno[3,2-b]pyridine adds to its structural novelty, contributing to varied interactions with biological targets.
  • Biological Activity: Such compounds are often investigated for their potential as inhibitors in various enzymatic processes, making them valuable in drug design.
  • Sulfamoyl Group: The sulfonamide moiety in this compound may influence its pharmacodynamics, enhancing solubility and metabolic stability.

As stated by prominent chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound embodies that idea — it demonstrates that complexity can lead to novel functionalities, opening pathways for new therapeutic agents.

Understanding how compounds like this interact within biological systems can pave the way for significant advancements in treating diseases. Investigating its interaction with biological targets could reveal essential insights into its therapeutic potential. The field remains vibrant as researchers continue to explore such intricate molecules for innovations in healthcare.