Brinzolamide | Solubility of Things

Identification

Molecular formula

C₁₂H₂₁N₃O₈S₃

CAS number

138890-62-7

IUPAC name

4-hydroxy-1,1-dioxo-2-(2-thienylmethyl)-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

State

Brinzolamide is typically a solid at room temperature. When used for therapeutic purposes, specifically in eye drops, it is formulated into a liquid suspension for ease of administration.

Melting point (Celsius)

131.00

Melting point (Kelvin)

404.15

Boiling point (Celsius)

500.00

Boiling point (Kelvin)

773.15

General information

Molecular weight

383.50g/mol

Molar mass

383.5040g/mol

Density

1.4640g/cm³

Appearence

Brinzolamide appears as a white to off-white powder. It is not very hygroscopic and has no significant odor. When formulated for medical use, it is commonly found in suspension form for ophthalmic solutions, appearing as a light, white suspension.

Comment on solubility

Solubility of 4-hydroxy-1,1-dioxo-2-(2-thienylmethyl)-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

The solubility of the compound 4-hydroxy-1,1-dioxo-2-(2-thienylmethyl)-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide (C₁₂H₂₁N₃O₈S₃) can be influenced by various factors such as its chemical structure, functional groups, and environmental conditions.

Key Factors Affecting Solubility:

Polarity: The presence of sulfonamide and hydroxyl groups contributes to the polarity of this compound, which typically aids in solubility in polar solvents.
Hydrogen Bonding: The ability to form hydrogen bonds with water can enhance solubility, especially given the hydroxyl groups.
Temperature: Generally, increased temperatures can enhance the solubility of many compounds; however, this should be evaluated specifically for this compound.

It is important to note that while the compound contains polar groups that could improve solubility in water, its overall structure may also present steric hindrance that can impact dissolution rates. Additionally, the presence of thienyl and sulfur components may introduce hydrophobic characteristics, leading to variable solubility in different solvents.

In conclusion, the solubility of 4-hydroxy-1,1-dioxo-2-(2-thienylmethyl)-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide is a complex interplay of its structural features and solvent interactions. Understanding these dynamics is essential for optimizing its application in various environments.

Interesting facts

Exploring 4-hydroxy-1,1-dioxo-2-(2-thienylmethyl)-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

This fascinating compound, known as 4-hydroxy-1,1-dioxo-2-(2-thienylmethyl)-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide, is part of the thiazine family, which has garnered considerable attention in medicinal chemistry. Here are some intriguing aspects to consider:

Diverse Applications: This compound boasts potential therapeutic applications due to its unique structure. Thiazine derivatives are commonly explored for their antibacterial and antifungal properties.
Sulfonamide Group: The presence of the sulfonamide functional group (~SO₂NH₂~) is noteworthy as it contributes to the biological activity, enabling the compound to interact effectively with various biological targets.
Antimicrobial Properties: Numerous studies have indicated that compounds containing thiazine structures may exhibit significant antimicrobial properties, making them candidates for developing new antibiotics.
Thienylmethyl Influence: The thienylmethyl substituent enhances the specificity of the compound. Thienyl rings are known for their electron-rich characteristics, which can affect how the compound interacts with protein targets.
Structural Complexity: The intricate architecture of this compound allows for a diverse range of chemical modifications, which can lead to enhanced potency and specificity in biological systems.

In summary, 4-hydroxy-1,1-dioxo-2-(2-thienylmethyl)-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide exemplifies the potential of thiazine derivatives in medicinal chemistry. As researchers continue to explore its properties and applications, it may play a significant role in addressing current medicinal challenges.

Synonyms

SCHEMBL5080690

BDBM11932

4-hydroxy-1,1-dioxo-2-(thiophen-2-ylmethyl)-2H,3H,4H-1$l^{6},7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide