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Ethoxzolamide

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Identification
Molecular formula
C9H10N2O4S3
CAS number
452-35-7
IUPAC name
4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
State
State

Ethoxzolamide is a solid at room temperature.

Melting point (Celsius)
208.50
Melting point (Kelvin)
481.70
Boiling point (Celsius)
292.60
Boiling point (Kelvin)
565.80
General information
Molecular weight
268.34g/mol
Molar mass
268.3360g/mol
Density
1.4830g/cm3
Appearence

Ethoxzolamide appears as a crystalline solid that is typically off-white to light yellow in color.

Comment on solubility

Solubility Overview of 4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide

The solubility of 4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide (C9H10N2O4S3) is influenced by its complex structure and various functional groups. Understanding its solubility characteristics is crucial for applications in pharmaceuticals and chemical synthesis.

Factors Influencing Solubility:

  • Polarity: The presence of sulfonamide and dioxo groups increases the polarity of the molecule, which generally enhances solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules can significantly improve solubility.
  • Thermodynamic Properties: The enthalpy and entropy changes upon dissolution affect the extent of solubility.

Generally, compounds with similar structural features may exhibit:

  • Good solubility in polar organic solvents, such as methanol or ethanol.
  • Limited solubility in non-polar solvents, due to the lack of favorable interactions.

In conclusion, while exact solubility data for C9H10N2O4S3 may not be extensively documented, its chemical characteristics suggest a tendency towards `moderate to good solubility` in polar environments, making it a candidate for diverse applications in chemical formulations.

Interesting facts

Interesting Facts about 4-(Ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide

This fascinating compound belongs to a unique class of thieno compounds, which are characterized by their incorporation of sulfur and nitrogen heteroatoms. Here are some intriguing facts about this compound:

  • Complex Structure: The intricate design of the compound features a thieno[2,3-b]thiopyran framework, which is known for its diverse biological activities, including antimicrobial and anti-inflammatory properties.
  • Medical Relevance: Compounds like this one are being explored for their potential therapeutic applications, particularly in drug discovery. The sulfonamide moiety is often associated with antibiotic properties, making it a point of interest in medicinal chemistry.
  • Novel Functional Groups: The presence of both ethylamine and sulfonamide functional groups adds to the compound's chemical reactivity and can influence its pharmacokinetic profile, including absorption, distribution, metabolism, and excretion in living organisms.
  • Diloids in Synthesis: The dioxo groups in the structure provide interesting synthetic pathways for chemists, allowing the exploration of various reactions that could lead to derivatives with enhanced biological activities.

As a future chemist or a seasoned scientist, you might appreciate how the exploration of such compounds not only contributes to our understanding of organic molecules but also enhances the development of new drugs that can combat various diseases. Observing how the unique structure of 4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide interacts with biological targets could reveal valuable insights into molecular interactions.

In conclusion, compounds like this one highlight the intricate relationship between chemical structure and biological function, demonstrating the endless possibilities for innovation in pharmaceutical chemistry.

Synonyms
120280-13-9
DORZOLAMIDE BASE
4-(ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
rac-Dorzolamide
4H-Thieno[2,3-b]thiopyran-2-sulfonamide,4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide
CHEMBL269001
4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
ent-Dorzolamide
(4R)-Dorzolamide
Dorzolamide impurity B
(4-Ethylamino)-5,6-dihydro-6-methyl-4H-thieno(2,3B)thiopyran-2-sulphonamide-7,7-dioxide
trans-6-Methyl-4-ethylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide
SCHEMBL3306381
DTXSID10274396
DTXSID70861261
IAVUPMFITXYVAF-UHFFFAOYSA-N
HMS3745I07
HMS3868E03
VEA27995
ZFA24972
BDBM50043906
AKOS015914563
ID181506
4-(Ethylamino)-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda~6~-thieno[2,3-b]thiopyran-2-sulfonamide