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4-(dichlorosulfamoyl)benzoic acid

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Identification
Molecular formula
C7H5Cl2NO4S
CAS number
2806-40-8
IUPAC name
4-(dichlorosulfamoyl)benzoic acid
State
State

At room temperature, 4-(dichlorosulfamoyl)benzoic acid is a solid. It generally takes a crystalline form and is stable under standard conditions.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
267.07g/mol
Molar mass
267.0670g/mol
Density
1.6500g/cm3
Appearence

The compound 4-(dichlorosulfamoyl)benzoic acid typically appears as a crystalline solid. The crystals are usually off-white to light beige in color, depending on purity and form.

Comment on solubility

Solubility of 4-(Dichlorosulfamoyl)benzoic Acid (C7H5Cl2NO4S)

The solubility of 4-(dichlorosulfamoyl)benzoic acid can be characterized by several key features:

  • Polar Substituents: The presence of both chlorine and a sulfamoyl group contributes to its polarity, which generally enhances solubility in polar solvents like water.
  • Acidic Nature: Given that it is a benzoic acid derivative, it can form salts with bases, potentially increasing its solubility in aqueous solutions if the conditions allow.
  • Solvent Dependency: While the compound may be more soluble in water due to its functional groups, its solubility can vary significantly in organic solvents. Typical organic solvents may show reduced solubility due to steric hindrances and the hydrophobic benzoic acid core.
  • Temperature Effects: As with many compounds, solubility may increase with temperature, allowing for a better dissolution in solvents.

It is essential to conduct experimental studies to establish definitive solubility data, as predictions based on structure alone may not account for all interactions in solution. Therefore, in practical applications, solubility assessments should consider both the environment and the formulation to ensure desired outcomes.

Interesting facts

Interesting Facts About 4-(Dichlorosulfamoyl)benzoic Acid

4-(Dichlorosulfamoyl)benzoic acid is a fascinating compound that showcases the intricate relationships between structure and function in chemical compounds. Here are some key points to note:

  • Pharmaceutical Relevance: This compound is often studied for its potential applications in medicinal chemistry, particularly as an antibacterial agent. Its structural features allow it to interact with biological systems in unique ways.
  • Functional Groups: The presence of multiple functional groups, including the sulfonamide and carboxylic acid, makes this compound a subject of interest for researchers exploring structure-activity relationships (SAR) in drug design.
  • Environmental Considerations: Like many chlorinated compounds, 4-(dichlorosulfamoyl)benzoic acid raises important questions about environmental impact and biodegradability. Understanding its fate in the environment is essential for assessing risk.
  • Synthetic Pathways: The synthesis of this compound is of importance in organic chemistry courses, demonstrating the practical applications of various reaction mechanisms, including nucleophilic substitutions and acylation processes.
  • Analytical Techniques: Investigating this compound often involves sophisticated analytical techniques such as NMR spectroscopy and mass spectrometry, providing students with hands-on experience in modern analytical methods.

As we delve deeper into the world of organic chemistry, 4-(dichlorosulfamoyl)benzoic acid serves as a reminder of the interconnectedness of chemical properties and biological activity. Its study not only expands our knowledge of chemical compounds but also underscores the importance of responsible chemistry in our society.

Synonyms
halazone
80-13-7
Halazon
Pantocid
Pantocide
4-(Dichlorosulfamoyl)benzoic Acid
Cloritines
Pantosid
Pentocid
Zeptabs
Pantotsid
Halazonum
p-(Dichlorosulfamoyl)benzoic acid
Halazone [INN]
p-Sulfondichloramidobenzoic acid
4-(N,N-Dichlorosulfamoyl)benzoic acid
p-Carboxybenzenesulfondichloroamide
Parasulfondichloramido benzoic acid
p-(N,N-Dichlorosulfamyl)benzoic acid
Halazona
p-(N,N-Dichlorosulfamoyl)benzoic acid
Benzoic acid, 4-((dichloroamino)sulfonyl)-
Benzoic acid, 4-[(dichloroamino)sulfonyl]-
Benzoic acid, p-(dichlorosulfamoyl)-
NSC 60717
NSC-60717
p-Dichlorosulfamoylbenzoic acid
G359OL82VB
DTXSID9025370
HALAZONE [MI]
HALAZONE [MART.]
HALAZONE [WHO-DD]
Kyselina p-N,N-dichlorsulfamoylbenzoova
4-[(dichloroamino)sulfonyl]benzoic acid
DTXCID205370
HALAZONE [USP MONOGRAPH]
4-((dichloroamino)sulfonyl)benzoic acid
NCGC00091225-02
Halazono
HALAZONE (MART.)
HALAZONE (USP MONOGRAPH)
Caswell No. 326
Halazonum [INN-Latin]
Halazono [INN-Spanish]
p-Sulfondichloramidobenzoic acid;Pentocid; Zeptabs;NSC 60717; Pantocid
CAS-80-13-7
CCRIS 6243
Halazone [USP:INN]
EINECS 201-253-1
EPA Pesticide Chemical Code 077201
BRN 2740018
UNII-G359OL82VB
4benzoic acid
Kyselina p-N,N-dichlorsulfamoylbenzoova [Czech]
Halazone (USP/INN)
Spectrum_000839
WLN: QVR DSWNGG
Spectrum2_000670
Spectrum3_000447
Spectrum4_000569
Spectrum5_000786
pDichlorosulfamoylbenzoic acid
SCHEMBL29353
BSPBio_002094
KBioGR_000978
KBioSS_001319
2-11-00-00220 (Beilstein Handbook Reference)
DivK1c_000683
pSulfondichloramidobenzoic acid
pSulfondichloramidobenzoid acid
SPECTRUM1500324
SPBio_000739
p(Dichlorosulfamoyl)benzoic acid
CHEMBL1368146
pCarboxybenzenesulfondichloroamide
HMS502C05
KBio1_000683
KBio2_001319
KBio2_003887
KBio2_006455
KBio3_001314
NINDS_000683
Benzoic acid, p(dichlorosulfamoyl)
HMS1920B21
HMS2091J07
p(N,NDichlorosulfamyl)benzoic acid
Pharmakon1600-01500324
HY-B1386
NSC60717
p(N,NDichlorosulfamoyl)benzoic acid
4(N,NDichlorosulfamoyl)benzoic acid
4CarboxyN,Ndichlorobenzenesulfonamide
Kyselina pN,Ndichlorsulfamoylbenzoova
Tox21_111104
Tox21_202519
CCG-39876
MFCD00045858
NSC757053
s6440
AKOS015891386
P-SULFONDICHLORAMIDOBENZOID ACID
Tox21_111104_1
NSC-757053
IDI1_000683
NCGC00091225-01
NCGC00091225-03
NCGC00091225-04
NCGC00091225-06
NCGC00260068-01
Benzoic acid, 4((dichloroamino)sulfonyl)
DA-53823
PARASULFONDICHLOROAMIDO BENZOIC ACID
SBI-0051400.P003
4-(N,N-DICHLOROSULFAMYL)BENZOIC ACID
CS-0013119
H0348
NS00041233
4-CARBOXY-N,N-DICHLOROBENZENESULFONAMIDE
D02446
D90842
AB00052007_02
SR-05000001638
Q4344352
SR-05000001638-1
BRD-K68091065-001-04-7
p-(N,N-Dichlorosulfamyl)benzoic acid, analytical standard, >=70% (TLC)
201-253-1