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4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide

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Identification
Molecular formula
C14H18ClN3O3S
CAS number
32997-05-0
IUPAC name
4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide
State
State

The compound is typically a solid at room temperature, appearing as a crystalline powder with a consistent texture.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
342.83g/mol
Molar mass
342.8310g/mol
Density
1.3100g/cm3
Appearence

The compound appears as a crystalline solid. It typically manifests as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide

The solubility of 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide (C14H18ClN3O3S) is influenced by a variety of factors due to its complex structure. Understanding its solubility profile is essential for applications in pharmaceuticals and industrial formulations. Here are some key points to consider:

  • Polarity: The presence of the sulfonamide group contributes to enhanced solubility in polar solvents.
  • Hydrogen Bonding: This compound can form hydrogen bonds due to its amide and sulfonamide functionalities, potentially increasing solubility in aqueous solutions.
  • Solvent Compatibility: It is likely to be soluble in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), which are polar aprotic solvents.
  • Temperature Effects: General solubility theory suggests that increasing temperature may enhance its solubility in some solvents.

In summary, while this compound may exhibit good solubility characteristics in certain solvents due to its polar groups and potential for hydrogen bonding, it's important to conduct empirical studies to determine its specific solubility limits under varying conditions. The intricacies of solubility can often reveal much about a compound's suitability for diverse applications.

Interesting facts

Interesting Facts about 4-Chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide

This compound is an intriguing member of the sulfamide class, known for its *pharmacological properties*. The structural complexity is notable, featuring a benzamide moiety linked to a piperidine ring, making it an interesting subject for medicinal chemistry research. Here are some fascinating points about this compound:

  • Biological Activity: Sulfamoylbenzamides are often studied for their potential *antimicrobial and anti-inflammatory activities*. This highlights the significance of the compound in drug development.
  • Mechanism of Action: This compound, like other sulfamides, may act by inhibiting *carbonic anhydrase*, an enzyme critical in many physiological processes. A deeper understanding could pave the way for new therapies.
  • Versatility in Synthesis: The synthetic pathway for creating such compounds can vary widely, allowing for modifications that can enhance potency or selectivity, making it a fantastic model for students learning about organic synthesis.
  • Chirality: The presence of a chiral center in the piperidine ring suggests that enantiomers could display different biological effects, an essential consideration in drug design.
  • Environmental Impact: The stability and persistence of this compound in biological and environmental systems are critical factors to consider in assessments of its safety and ecological toxicity.

As you explore the chemistry behind 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide, remember the interconnectedness of its structure and function, which emphasizes the *vital role* of chemical compounds in developing therapeutic agents.

Synonyms
Chlosudimeprimylum
Aquex
Brinaldix
MLS000551289
DTXSID1022847
SMR000145215
Chlorsudimeprimyl
DTXCID802847
4-Chloro-N-(2,6-dimethyl-piperidin-1-yl)-3-sulfamoyl-benzamide
NCGC00016527-01
3563-77-7
CAS-636-54-4
Spectrum_001568
Opera_ID_864
4-chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide
Prestwick0_000354
Prestwick1_000354
Prestwick2_000354
Spectrum2_001595
Spectrum3_001891
Spectrum4_000207
Spectrum5_001563
Oprea1_353822
BSPBio_003422
KBioGR_000813
KBioSS_002048
Adurix; Aquex; Brinaldix; Chlosudimeprimyl;Clopamidum; DT 327
MLS001201776
MLS006010787
DivK1c_000946
SCHEMBL124598
SPECTRUM1503919
SPBio_001590
SPBio_002368
Benzamide, 4-chloro-N-(2,6-dimethylpiperidino)-3-sulfamoyl-, cis-
3-(Aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)benzamide-, cis-
CHEMBL1361347
CHEBI:95210
HMS502P08
KBio1_000946
KBio2_002048
KBio2_004616
KBio2_007184
KBio3_002925
NINDS_000946
HMS1569G09
HMS2093K21
HMS2233P13
HMS3371C11
HMS3374M01
Tox21_110475
BDBM50237613
CCG-39373
1-6-Hexamethylene-bis-(3-benzylquinuclidium)chloride tetrahydrate Qualidil
AKOS024374908
IDI1_000946
NCGC00016527-03
NCGC00018272-02
NCGC00018272-03
NCGC00096000-01
NCGC00096000-02
LS-14327
SBI-0051860.P002
DB-054517
SW196897-2
SR-01000675440
Q5135114
SR-01000675440-2
BRD-A85651701-001-03-1
BRD-A85651701-001-19-7
4-chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide
3-(aminosulfonyl)-4-chloro-N-(2,6-dimethylpiperidin-1-yl)benzamide