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4-Chloro-N-(2-morpholinoethyl)benzamide

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Identification
Molecular formula
C13H17ClN2O2
CAS number
6780-23-8
IUPAC name
4-chloro-N-(2-morpholinoethyl)benzamide
State
State
At room temperature, 4-Chloro-N-(2-morpholinoethyl)benzamide is typically in a solid state.
Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
512.50
Boiling point (Kelvin)
785.65
General information
Molecular weight
268.74g/mol
Molar mass
268.7480g/mol
Density
1.3190g/cm3
Appearence

4-Chloro-N-(2-morpholinoethyl)benzamide typically appears as a solid substance. The compound can form crystalline structures and is generally white to off-white in color.

Comment on solubility

Solubility of 4-chloro-N-(2-morpholinoethyl)benzamide

The solubility of 4-chloro-N-(2-morpholinoethyl)benzamide, with the chemical formula C13H17ClN2O2, can be influenced by various factors including its molecular structure and the presence of functional groups. This compound contains both a chloro group and a morpholino moiety, which play critical roles in its solubility properties.

Here are some key points regarding its solubility:

  • Polar vs. Nonpolar Interaction: The presence of the morpholino group suggests some degree of polar character, which can enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the nitrogen and oxygen atoms in the structure can further aid in solubility in aqueous environments.
  • Organic Solvents: In organic solvents, the solubility may vary substantially, often depending on the solvent's polarity. The compound might be more soluble in moderately polar organic solvents.
  • Temperature Dependency: Similar to many organic compounds, its solubility may increase with temperature, hence experiments conducted at elevated temperatures might yield improved solubility results.

In summary, while specific solubility data for 4-chloro-N-(2-morpholinoethyl)benzamide may not be readily available, the structural characteristics point towards a potentially moderate solubility in polar solvents. Always consult further experimental data for precise applications.

Interesting facts

4-chloro-N-(2-morpholinoethyl)benzamide

4-chloro-N-(2-morpholinoethyl)benzamide is a fascinating chemical compound with distinct characteristics that have garnered attention in the field of medicinal chemistry. This compound is classified as an amide, which is a functional group commonly found in various pharmaceuticals and bioactive molecules. Here are some interesting insights about this intriguing compound:

  • Biological Relevance: The presence of the morpholino group in its structure enhances the compound's potential as a drug candidate, particularly in neuroscience and oncology, as morpholines are known to interact with various biological targets.
  • Chlorine as a Game Changer: The chlorine atom in the 4-position of the benzene ring plays a significant role in modifying the compound’s properties, affecting both its lipophilicity and overall bioactivity.
  • Structure-Activity Relationship (SAR): Researchers often explore SAR to understand how changes in molecular structure influence biological activity. This compound serves as a valuable model for studying such relationships, especially regarding its amide functionality.
  • Applications in Drug Design: The unique structure of 4-chloro-N-(2-morpholinoethyl)benzamide makes it a candidate for developing new pharmaceuticals, showcasing the importance of chemical diversity in drug design.
  • Synthetic Pathways: The synthesis of this compound often involves various methods of functional group transformations, providing chemistry students with practical insights into organic synthesis techniques.

In summary, 4-chloro-N-(2-morpholinoethyl)benzamide is more than just a chemical formula; it represents a complex interplay of molecular features that influences its potential therapeutic applications. As the pharmaceutical landscape evolves, compounds like this one will continue to play a crucial role in the development of innovative treatments.

Synonyms
moclobemide
71320-77-9
Aurorix
Moclobemid
Manerix
4-chloro-N-(2-morpholinoethyl)benzamide
Moclaime
Moclamine
Moclobemida
Moclobemidum
Moclamide
Moclobemidum [INN-Latin]
Moclobemida [INN-Spanish]
p-Chloro-N-(2-morpholinoethyl)benzamide
4-Chlor-N-(2-morpholinoethyl)benzamid
Ro 11-1163
GNF-PF-695
4-Chloro-N-(2-morpholin-4-yl-ethyl)-benzamide
4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide
Auromid
4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide
Moclobemide (Ro 111163)
Moclobemide [USAN:INN:BAN]
4-chloro-N-(2-morpholin-4-ylethyl)benzamide
Ro 11-1163/000
Aurorix (TN)
4-chloro-N-[2-(4-morpholinyl)ethyl]benzamide
C13H17ClN2O2
HSDB 7180
BENZAMIDE, 4-CHLORO-N-(2-(4-MORPHOLINYL)ETHYL)-
Benzamide, 4-chloro-N-[2-(4-morpholinyl)ethyl]-
PJ0Y7AZB63
BRN 0530974
DTXSID9040554
CHEBI:83531
Moclamine (Salt/Mix)
MOCLOBEMIDE [MI]
Moclobamide
MOCLOBEMIDE [INN]
Ro111163
MOCLOBEMIDE [HSDB]
MOCLOBEMIDE [USAN]
MOCLOBEMIDE [MART.]
MOCLOBEMIDE [WHO-DD]
CHEMBL86304
MLS000070549
Ro-111163000
DTXCID7020554
Ro-11-1163/000
MFCD00865388
NCGC00027930-02
NCGC00027930-04
SMR000012114
Moclobemidum (INN-Latin)
Moclobemida (INN-Spanish)
MOCLOBEMIDE (MART.)
Moclobemide [USAN:BAN:INN]
CAS-71320-77-9
Ro-11-1163
4-chloro-N-(2-(morpholin-4-yl)ethyl)benzamide
SR-01000357772
CBMicro_048319
Moclobemide (USAN/INN)
UNII-PJ0Y7AZB63
Moclobemide?
Ro-11-1163, Aurorix, Manerix, Moclamine, p-Chloro-N-(2-morpholinoethyl)benzamide
Moclobemide (Standard)
Opera_ID_225
4-CHLORO-N-
Oprea1_256739
Oprea1_270122
SCHEMBL49708
MLS000759438
MLS001240195
MLS001424077
GTPL7428
BENZAMIDE,4-CHLORO-N-[2-(4-MORPHOLINYL)ETHYL]-
Moclobemide - Bio-X trade mark
BDBM15613
HY-B0534R
N06AG02
HMS2051A16
HMS2096G07
HMS2232B20
HMS3262F09
HMS3371A01
HMS3393A16
HMS3657K05
HMS3713G07
HMS3885A15
BCP15783
HY-B0534
Moclobemide 1.0 mg/ml in Methanol
Tox21_110971
Tox21_113614
Tox21_500824
HB1791
s3212
STK222240
AKOS003270184
Moclobemide, >=98% (HPLC), solid
Tox21_110971_1
CCG-100879
DB01171
FM26030
LP00824
NC00129
SDCCGSBI-0048213.P003
NCGC00027930-03
NCGC00027930-05
NCGC00027930-07
NCGC00027930-16
NCGC00261509-01
AC-12467
AC-35244
BM164599
p-chloro-N-(2-morpholinoethyl)-benzamide
BIM-0048213.P001
M2733
NS00009131
SW197509-3
D02561
EN300-761488
4-Chloro-N-[2-(4-morpholinyl)ethyl] benzamide
AB00400932_12
Q421934
SR-01000357772-1
SR-01000357772-4
BRD-K07237224-001-19-6
Z32409934
Ro11-1163; Ro 11-1163; Ro111163; Ro-111163; Ro 111163
108375-13-9