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Bortezomib

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Identification
Molecular formula
C19H25BN4O4S
CAS number
179324-69-7
IUPAC name
[4-carbamimidoylsulfanyl-1-[[1-[3-phenyl-2-(propanoylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid
State
State

The compound is typically a solid at room temperature.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
384.23g/mol
Molar mass
384.2340g/mol
Density
1.3000g/cm3
Appearence

Bortezomib appears as a white to off-white crystalline powder. It is usually quite fine and has a slightly crystalline structure.

Comment on solubility

Solubility of 4-carbamimidoylsulfanyl-1-[[1-[3-phenyl-2-(propanoylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid

The solubility of 4-carbamimidoylsulfanyl-1-[[1-[3-phenyl-2-(propanoylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid, with the chemical formula C19H25BN4O4S, can present intriguing challenges due to its complex structure. The solubility characteristics are influenced by several factors:

  • Polarity: The presence of polar functional groups, such as boronic acid and amine functionalities, can enhance solubility in polar solvents, including water.
  • Hydrophobicity: The aromatic and aliphatic groups can render parts of the molecule hydrophobic, potentially limiting solubility in aqueous environments.
  • pH Dependency: As a boronic acid, its solubility may vary with pH changes, affecting the dissociation of its acidic protons.

In general, we might expect this compound to be:

  1. Soluble in: Polar solvents such as water and alcohols at certain concentrations.
  2. Insoluble in: Non-polar solvents due to the presence of hydrophobic regions.

In conclusion, the intricate balance of polar and non-polar elements within the molecular structure leads to a specific solubility profile that can be sensitive to environmental conditions. This is exemplified by the statement, "The solubility of a compound is often a reflection of its molecular architecture." Understanding these solubility characteristics is crucial for applications in pharmaceuticals and materials science, where solubility can significantly influence functionality and effectiveness.

Interesting facts

Interesting Facts about 4-Carbamimidoylsulfanyl-1-[[1-[3-phenyl-2-(propanoylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid

This compound is a fascinating example of a boronic acid, which is notable not just for its structural complexity but also for its biological significance. Here are some interesting insights:

  • Versatile Functionality: Boronic acids are well-known for their ability to form reversible covalent bonds with diols. This unique property makes them invaluable in various applications, including drug design and catalysis.
  • Role in Medicinal Chemistry: Compounds like this one are often explored in the development of pharmaceuticals, particularly for their potential anti-cancer properties. Researchers continuously seek to innovate and improve upon existing drugs by modifying these boronic acid scaffolds.
  • Integration of Multiple Moieties: This compound features diverse functional groups, including a carbamimidoyl group and a propanoylamino chain. The combination of these functional groups may enhance its specificity and activity against biological targets.
  • Peptide Mimics: The design of this compound emphasizes the creation of peptide mimics, which can have improved stability in biological systems compared to their natural counterparts. This can lead to better therapeutic outcomes.

As a scientist or a chemistry student, you might find it intriguing to explore how the integration of different chemical functionalities can lead to innovative therapies that target complex diseases. The study of such compounds often leads to breakthroughs in understanding mechanisms of action and developing new treatments.

In conclusion, the intricate structure and potential applications of 4-carbamimidoylsulfanyl-1-[[1-[3-phenyl-2-(propanoylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid represent a rich avenue for research in modern chemistry and pharmacology.

Synonyms
SCHEMBL8166601