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Phenylbutazone

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Identification
Molecular formula
C19H20N2O2
CAS number
50-33-9
IUPAC name
4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione
State
State

Phenylbutazone is in a solid state at room temperature. It is typically handled as a powder in pharmaceutical and chemical settings.

Melting point (Celsius)
103.00
Melting point (Kelvin)
376.15
Boiling point (Celsius)
745.30
Boiling point (Kelvin)
1 018.45
General information
Molecular weight
308.38g/mol
Molar mass
308.3750g/mol
Density
1.2300g/cm3
Appearence

Phenylbutazone appears as a white or slightly yellow crystalline powder. It is tasteless and does not have any distinct odor. The compound is usually utilized in its solid form and is known for having a crystalline structure.

Comment on solubility

Solubility of 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione (C19H20N2O2)

The solubility of 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione can be quite intriguing due to its complex molecular structure. This compound features both hydrophobic and polar functional groups, which influence its solubility behavior in various solvents.

Solubility Characteristics:

  • Polar Solvents: Its polar groups suggest that it may demonstrate some solubility in polar solvents such as ethanol and methanol.
  • Non-Polar Solvents: The butyl and phenyl groups enhance non-polar characteristics, potentially increasing solubility in non-polar solvents like hexane.
  • Water Solubility: Given its substantial lipophilicity due to the presence of bulky hydrocarbon chains, it is expected to have low solubility in water.

Moreover, the solubility of organic compounds like this one can be affected by temperature and the presence of other solutes or solvent conditions. As a general observation, the intricate balance between hydrophilic and hydrophobic interactions in 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione suggests that while it may dissolve well in certain organic solvents, its overall solubility profile would likely be moderate to low in aqueous environments.

In summary, the solubility of this compound is a **dynamic property** that can vary significantly depending on the choice of solvent. Understanding this solubility behavior is key for applications ranging from synthesis to pharmaceutical formulation.

Interesting facts

Exploring 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione

4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione, often referred to in research as a promising chemical compound, belongs to the *pyrazolidine* family, which is known for its diverse applications in various fields of chemistry and pharmacology. Here are some intriguing facts about this compound:

  • Medicinal Applications: This compound has demonstrated potential in the realm of medicinal chemistry, where certain derivatives have been studied for their anti-inflammatory and analgesic effects.
  • Chemical Versatility: The structure of 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione allows for versatile modifications, making it an interesting subject for chemical synthesis and the exploration of structure-activity relationships.
  • Mechanism of Action: While the full mechanism of action is still an active area of research, initial studies suggest that compounds in this class may influence various biological pathways, including those related to pain and inflammation.
  • Importance of Substituents: The presence of butyl and diphenyl groups significantly affects the compound’s reactivity and stability, enhancing its potential for further modifications and applications in drug design.

Research Significance

As a student or scientist delving into the world of medicinal chemistry, understanding compounds like 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione can be enlightening. The relationships between molecular structure and biological activity offer a profound insight into how slight variations can lead to significant changes in efficacy and safety. It's a reminder of the *intricate dance* between chemistry and biology in drug development.

Further research into this compound could pave the way for innovative treatments and enhance our understanding of pyrazolidine derivatives. As you explore this fascinating compound, keep in mind the potential it holds for future medicinal breakthroughs.


Synonyms
phenylbutazone
50-33-9
4-Butyl-1,2-diphenylpyrazolidine-3,5-dione
Butapirazol
Butazolidin
Fenilbutazona
Butadion
Diphenylbutazone
Butazolidine
Fenibutazona
Fenylbutazon
Intrabutazone
Artrizin
Butacote
Butadiona
Diphebuzol
Ecobutazone
Fenibutol
Intrazone
Phebuzine
Azolid
Butoz
Buzon
Phenylbutazonum
Butapyrazole
Equipalazone
Flexazone
Bute
Alkabutazona
Butapirazole
Chembutazone
Mephabutazon
Mephabutazone
Praecirheumin
Scanbutazone
Alqoverin
Anpuzone
Anuspiramin
Arthrizon
Artrizone
Artropan
Azobutyl
Bunetzone
Butacompren
Butagesic
Butalgina
Butalidon
Butarecbon
Butartril
Butartrina
Butazina
Butazona
Butidiona
Butylpyrin
Buvetzone
Digibutina
Diossidone
Eributazone
Febuzina
Fenartil
Fenibutal
Fenibutasan
Fenilbutina
Fenilbutine
Fenilidina
Fenotone
Intalbut
Ipsoflame
Malgesic
Merizone
Nadazone
Nadozone
Novophenyl
Phebuzin
Phenbutazol
Phenopyrine
Phenylbutaz
Phenyzone
Pyrabutol
Pyrazolidin
Rectofasa
Reumasyl
Reumazin
Reumazol
Reumuzol
Reupolar
Robizone
Rubatone
Zolaphen
Alindor
Anerval
Antadol
Benzone
Betazed
Bizolin
Busone
Butaluy
Butone
Diozol
Elmedal
Lingel
Reudox
Reumune
Kadol
Reudo
Uzone
Butiwas-Simple
Neo-zoline
Phenyl-Mobuzon
Equi bute
Exrheudon N
Robizone-V
4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
Robizon-V
Phenylbutazon
Butaphen
Shigrodin
Tevcodyne
Azdid
Ia-But
Pirarreumol B
Buta phen
4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine
Bizolin 200
Phenbutazone
Schemergin
Butatron
Wescozone
Tazone
Phen-Buta-Vet
Phenyzene
Tencodyne
Therazone
Todalgil
Zolidinum
Tetnor
Ticinil
3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-
B.t.z.
Mepha-Butazon
3,5-Dioxo-1,2-diphenyl-4-N-butylpyrazolidine
4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE
Phenyl butazone
Usaf ge-15
R-3-ZON
4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
VAC-10
A 7514
DA-192
1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione
3,5-Dioxo-1,2-diphenyl-4-n-butyl-pyrazolidin
G 13,871
1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine
1,2-Diphenyl-4-butyl-3,5-dioxopyrazolidine
CHEBI:48574
Fenilbutazon
MFCD00005500
NSC-25134
GN5P7K3T8S
50-33-9 (free form)
MLS000069424
Butadionum
Schemergen
DTXSID9021136
NCI-C55414
'Esteve'
NCGC00015846-10
NCGC00015846-11
Fenilbutazone
SMR000059073
Fenilbutazone [DCIT]
Phenylbutazon [German]
G-13871
P1Z
DTXCID601136
Fenilbutazona [INN-Spanish]
Phenylbutazonum [INN-Latin]
CAS-50-33-9
CCRIS 2374
component of Azolid-A
HSDB 3159
3,5-Dioxe-4 buty-1, diphenyl-pyrazolidine
NCI-C56531
SR-01000000004
AZOLID (TN)
EINECS 200-029-0
NSC 25134
G 13871
UNII-GN5P7K3T8S
BRN 0290080
Alkazone
Phenogel
Phen-Buta
Pirarreumol 'B'
Phenylbutazone [USP:INN:BAN:JAN]
1,5-dioxopyrazolidine
Spectrum_001079
4-Butyl-1,5-dione
Opera_ID_888
Spectrum2_001282
Spectrum3_000675
Spectrum4_000477
Spectrum5_001335
Lopac-P-8386
Phenylbutazone (Standard)
P1686
Epitope ID:124940
P 8386
PHENYLBUTAZONE [MI]
SCHEMBL3632
PHENYLBUTAZONE [INN]
PHENYLBUTAZONE [JAN]
Lopac0_000993
Oprea1_416494
BSPBio_002369
KBioGR_000954
KBioSS_001559
PHENYLBUTAZONE [HSDB]
PHENYLBUTAZONE [IARC]
MLS001148412
MLS002152929
DivK1c_000331
PHENYLBUTAZONE [VANDF]
SPECTRUM1500482
SPBio_001283
PHENYLBUTAZONE [MART.]
1,5-dioxo-4-butylpyrazolidine
3, 4-butyl-1,2-diphenyl-
4-Butyl-1,5-dioxopyrazolidine
4-Butyl-1,5-pyrazolidinedione
GTPL7270
PHENYLBUTAZONE [USP-RS]
PHENYLBUTAZONE [WHO-DD]
1,3-dioxo-4-N-butylpyrazoline
HMS501A13
HY-B0230R
KBio1_000331
KBio2_001559
KBio2_004127
KBio2_006695
KBio3_001589
NINDS_000331
Phenylbutazone (JP18/USP/INN)
BCPP000108
HMS1920H06
HMS2090H17
HMS2091P08
HMS2233B13
HMS3263G07
HMS3369P16
HMS3649M17
HMS3651G15
HMS3715E21
HMS3884C06
Pharmakon1600-01500482
Phenylbutazone, analytical standard
component of Azolid-A (Salt/Mix)
Phenylbutazone - Bio-X trade mark
PHENYLBUTAZONE [GREEN BOOK]
BCP02607
HY-B0230
NSC25134
3,2-diphenyl-4-N-butylpyrazolidine
PHENYLBUTAZONE [ORANGE BOOK]
Tox21_110242
Tox21_110243
Tox21_201809
Tox21_302763
Tox21_500993
3,2-diphenyl-4-N-butyl-pyrazolidin
AC-683
CCG-39220
NSC757272
PHENYLBUTAZONE [EP MONOGRAPH]
s1654
STK388348
PHENYLBUTAZONE [USP MONOGRAPH]
AKOS001592731
Phenylbutazone (Butazolidin, Butatron)
Tox21_110242_1
DB00812
FP26944
KS-5127
LP00993
NSC-757272
SDCCGSBI-0050966.P005
WLN: T5VNNV EHJ BR& CR& E4
IDI1_000331
NCGC00015846-01
NCGC00015846-02
NCGC00015846-03
NCGC00015846-04
NCGC00015846-05
NCGC00015846-06
NCGC00015846-07
NCGC00015846-08
NCGC00015846-09
NCGC00015846-12
NCGC00015846-13
NCGC00015846-15
NCGC00015846-27
NCGC00023855-03
NCGC00023855-04
NCGC00023855-05
NCGC00023855-06
NCGC00023855-07
NCGC00023855-08
NCGC00181112-01
NCGC00256449-01
NCGC00259358-01
NCGC00261678-01
4297-92-1
BP166190
SBI-0050966.P004
DB-051755
SUXIBUZONE IMPURITY A [EP IMPURITY]
EU-0100993
NS00000675
SW199456-2
UNM000001255503
1,2-diphenyl-3,5-dioxo-4-butyl-pyrazolidine
Phenylbutazone, SAJ special grade, >=99.0%
1,2-diphenyl-3,5-dioxo-4-n-butylpyrazolidine
C07440
D00510
EN300-126733
1,2-diphenyl-3,5-dioxo-4-n-butyl-pyrazolidine
AB00052071-15
AB00052071-16
AB00052071_17
AB00052071_18
A828072
AG-205/04675049
Q421342
SR-01000000004-2
SR-01000000004-4
SR-01000000004-5
SR-01000000004-9
BRD-K10843433-001-12-8
BRD-K10843433-001-20-1
BRD-K10843433-001-21-9
BRD-K10843433-001-22-7
BRD-K10843433-001-23-5
SR-01000000004-13
Z57355370
Phenylbutazone, TraceCERT(R), certified reference material
Phenylbutazone, European Pharmacopoeia (EP) Reference Standard
Phenylbutazone, United States Pharmacopeia (USP) Reference Standard
InChI=1/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H