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4-Aminobenzamidine

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Identification
Molecular formula
C7H9N3
CAS number
4403-71-8
IUPAC name
4-aminobenzamidine
State
State

At room temperature, 4-aminobenzamidine is a solid, specifically existing as a crystalline powder.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.20
Boiling point (Celsius)
382.60
Boiling point (Kelvin)
655.80
General information
Molecular weight
135.17g/mol
Molar mass
135.1720g/mol
Density
1.3333g/cm3
Appearence

4-Aminobenzamidine appears as a white to off-white crystalline powder. It is typically odorless and may clump due to its crystalline nature.

Comment on solubility

Solubility of 4-Aminobenzamidine (C7H9N3)

The solubility characteristics of 4-aminobenzamidine can be quite fascinating. This compound belongs to the class of amidines, which generally exhibits interesting solubility behavior due to their polar functional groups.

Key Points on Solubility:

  • Water Solubility: 4-aminobenzamidine is reported to have moderate solubility in water, largely attributed to its amino and amidine groups that can engage in hydrogen bonding with water molecules.
  • Organic Solvents: The solubility in organic solvents can vary widely. Common solvents include dimethyl sulfoxide (DMSO) and ethanol, where the compound tends to be more soluble due to the non-polar characteristics of these solvents.
  • pH Dependence: The solubility of this compound may be influenced by pH levels in the solution. In acidic conditions, the protonation of the amine group can enhance solubility.
  • Temperature Effects: Like many organic compounds, the solubility may increase with higher temperatures, making it easier to dissolve 4-aminobenzamidine in heated aqueous solutions or organic solvents.

As a general rule, the solubility of amidines in water and organic solvents can be substantial, and understanding the solubility profile of 4-aminobenzamidine is crucial for applications in biological systems and pharmaceuticals. Furthermore, precise conditions in laboratory settings can be tailored to achieve optimal solubility for experimental needs.

Interesting facts

Interesting Facts about 4-Aminobenzamidine

4-Aminobenzamidine is a fascinating compound with numerous applications and properties that pique the interest of chemists and researchers alike. Here are some intriguing aspects:

  • Key Functional Groups: This compound features both an amine group and an amidine, which allows it to behave as a versatile building block in synthetic organic chemistry.
  • Role as a Precursor: 4-Aminobenzamidine is utilized as a precursor in the synthesis of various pharmaceuticals and biologically active compounds, making it a valuable asset in medicinal chemistry.
  • Enzyme Inhibition: The compound has been studied for its potential to inhibit certain enzymes, which can be beneficial in developing treatments for diseases such as cancer and hypertension.
  • Structure Functions: The molecular structure, featuring a benzene ring, contributes to its stability and reactivity, which are essential in drug formulation processes.
  • Research Applications: Scientists examine 4-Aminobenzamidine for its applications in diagnostics, particularly in developing probes to study enzyme activities.

As noted by researchers, "4-aminobenzamidine’s ability to mimic natural substrates makes it a focal point in studying enzyme mechanisms." This capability enhances its utility in pharmacology, making it an important compound in modern drug discovery.

With ongoing research, the full potential of 4-Aminobenzamidine continues to unfold, promising exciting developments in the fields of chemistry and medicine.

Synonyms
4-aminobenzamidine
p-Aminobenzamidine
3858-83-1
4-Aminobenzenecarboximidamide
4-aminobenzimidamide
Benzenecarboximidamide, 4-amino-
Benzamidine, p-amino-
EINECS 223-370-7
4-Amino-benzamidine
NSC 227928
BRN 0386209
63GK9KT599
NSC-227928
4-AMINOBENZENE-1-CARBOXIMIDAMIDE
CHEMBL124632
DTXSID30191899
para-aminobenzamidine
p-Aminobenzamidine (dihydrochloride)
UNII-63GK9KT599
Lopac-A-7148
Lopac0_000070
1329499-33-3
ABD
SCHEMBL150756
WPANETAWYGDRLL-UHFFFAOYSA-
DTXCID20114390
BBL007616
BDBM50092660
NSC227928
STK367857
AKOS005444850
Benzenecarboximidamide, 4-amino-(9CI)
CCG-204165
SDCCGSBI-0050058.P002
NCGC00015084-01
NCGC00015084-02
NCGC00015084-03
NCGC00015084-04
NCGC00015084-05
NCGC00162057-01
DA-17009
(6S)-Tetrahydro-L-biopterin-d3 Disulfate
CS-0165920
NS00030422
EN300-70197
AB00374717-08
4-aminobenzimidamide? (Dabigatran Impurity pound(c)
Q27263611
InChI=1/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10)
223-370-7