Sulfadiazine | Solubility of Things

Identification

Molecular formula

C₁₀H₁₀N₄O₂S

CAS number

68-35-9

IUPAC name

4-amino-N-pyrimidin-2-yl-benzenesulfonamide

State

At room temperature, sulfadiazine is in a solid state.

Melting point (Celsius)

253.00

Melting point (Kelvin)

526.15

Boiling point (Celsius)

546.60

Boiling point (Kelvin)

819.75

General information

Molecular weight

250.28g/mol

Molar mass

250.2810g/mol

Density

1.7300g/cm³

Appearence

Sulfadiazine is a white or slightly yellowish crystalline powder. It is practically odorless and it has a slightly bitter taste.

Comment on solubility

Solubility of 4-amino-N-pyrimidin-2-yl-benzenesulfonamide

The solubility of 4-amino-N-pyrimidin-2-yl-benzenesulfonamide, with the chemical formula C₁₀H₁₀N₄O₂S, is a noteworthy characteristic that can influence its applications in various chemical and pharmaceutical contexts. When considering the solubility of this compound, several factors come into play:

Polarity: The presence of the sulfonamide group typically enhances solubility in polar solvents, such as water.
Functional groups: The amino group and the pyrimidine ring can contribute to hydrogen bonding, further increasing the potential for solubility in aqueous environments.
Solvent choice: While this compound may exhibit reasonable solubility in water, it may also dissolve better in organic solvents, depending on the polarity and composition of the solvent.

Examining the intrinsic solubility is essential because:

It determines how effectively the compound can be administered or utilized in biological systems.
It influences the formulation of pharmaceutical products, impacting factors like bioavailability.

In conclusion, while 4-amino-N-pyrimidin-2-yl-benzenesulfonamide is expected to have moderate solubility characteristics, understanding its behavior in various solvents can aid in optimizing its use in practical applications.

Interesting facts

Interesting Facts about 4-Amino-N-pyrimidin-2-yl-benzenesulfonamide

4-amino-N-pyrimidin-2-yl-benzenesulfonamide, commonly known in the scientific community for its significance in medicinal chemistry, is a compound that has sparked substantial interest due to its unique properties and applications. Here are some fascinating aspects of this compound:

Pharmaceutical Relevance: This compound is often studied for its potential roles in the treatment of certain diseases, particularly as a *sulfonamide antibiotic*. Sulfonamides are known for their ability to inhibit bacterial growth.
Structural Significance: The presence of the pyrimidine ring in its structure contributes to its biological activity. Pyrimidines are a key component in nucleic acids, emphasizing the connection between structure and function in biological systems.
Sulfonamide Group: The benzenesulfonamide moiety makes it an interesting candidate for studies related to *enzyme inhibition*, particularly in the context of folate metabolism.
Synthetic Pathways: This compound can be synthesized through various organic reactions, making it a valuable target for synthetic chemists. Exploring different synthetic routes can lead to new derivatives with potentially enhanced activity.
Research Applications: Scientists are investigating its role in drug design and the development of novel therapies. This includes studying modifications to improve efficacy and reduce side effects.

In summary, 4-amino-N-pyrimidin-2-yl-benzenesulfonamide is more than just a chemical formula; it represents a gateway to understanding valuable pharmacological interactions and the quest for new therapies in medicine. As you delve into its molecular framework, consider the vast implications of each component and how they interact within biological systems.

Synonyms

sulfadiazine

68-35-9

Sulphadiazine

Sulfapyrimidine

Sulfadiazin

Sulfazine

Adiazine

Sulfadiazene

Adiazin

Debenal

Pyrimal

Liquadiazine

Sulfapyrimidin

Coco-Diazine

2-Sulfanilamidopyrimidine

Cremodiazine

Cremotres

Deltazina

Diazolone

Eskadiazine

Microsulfon

Palatrize

Piridisir

Quadramoid

Sanodiazine

Spofadrizine

Sterazine

Sulfadiazina

Sulfatryl

Sulfonsol

Theradiazine

Trifonamide

Neazine

Pirimal

Quadetts

Truozine

Trisem

Honey diazine

Sulfanilamidopyrimidine

Lipo-Diazine

Lipo-Levazine

Tri-Sulfameth

Metha-Meridiazine

Sulfadiazinum

Diazovit

Neotrizine

Sulfolex

Terfonyl

Diazin

Sulfose

Sulphadiazine E

Triple Sulfas

Di-Azo-Mul

Thi-Di-Mer

2-Sulfanilylaminopyrimidine

Sulfapirimidin

4-amino-N-(pyrimidin-2-yl)benzenesulfonamide

Pecta-diazine, suspension

Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-

Solfadiazina

Codiazine

Silvadene

4-amino-N-pyrimidin-2-ylbenzenesulfonamide

2-Sulfanilamidopyrimidin

Pyrimidine, 2-sulfanilamido-

RP 2616

N(1)-2-pyrimidylsulfanilamide

N(1)-2-pyrimidinylsulfanilamide

2-Sulfapyrimidine

4-AMINO-N-2-PYRIMIDINYLBENZENESULFONAMIDE

N(sup 1)-2-Pyrimidinylsulfanilamide

Sulfadiazinum [INN-Latin]

Sulfanilamide, N1-2-pyrimidinyl-

S.N. 112

Sulfadiazina [INN-Spanish]

A 306

CHEBI:9328

Sulfanilamide, N(sup 1)-2-pyrimidinyl-

4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide

Sulfanilamide, N1-2(1H)-pyrimidinylidene-

4-amino-N-pyrimidin-2-yl-benzenesulfonamide

A-306

EINECS 200-685-8

MFCD00006065

NSC 35600

Sildaflo

BRN 0235192

DTXSID7044130

4-Amino-N-2-pyrimidinyl-benzenesulfonamide

AI3-01047

N(sup1)-2-Pyrimidylsulfanilamide

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide

UNII-0N7609K889

silver sulfadiazine

N(sup1)-2-Pyrimidinylsulfanilamide

NSC35600

CHEMBL439

S. N. 112

0N7609K889

DTXCID5024130

Sulfadiazine [USP:INN:BAN:JAN]

5-25-10-00067 (Beilstein Handbook Reference)

SULFOSE COMPONENT SULFADIAZINE

NSC-35600

TERFONYL COMPONENT SULFADIAZINE

LANTRISUL COMPONENT SULFADIAZINE

SULFALOID COMPONENT SULFADIAZINE

SDZ

CAS-68-35-9

NEOTRIZINE COMPONENT SULFADIAZINE

NCGC00016305-01

TRISULFAPYRIMIDINES (SULFADIAZINE)

CocoDiazine

Solfadiazina [DCIT]

Sulfadiazine 100 microg/mL in Acetonitrile

TRIPLE SULFOID COMPONENT SULFADIAZINE

NSC117870

Sulfapyrimidin [German]

Sulfadiazinum (INN-Latin)

Benzenesulfonamide, 4-amino-N-(2-pyrimidinyl)-

RP-2616

Sulfadiazina (INN-Spanish)

SULFADIAZINE (MART.)

SULFADIAZINE [MART.]

SULFADIAZINE (USP-RS)

SULFADIAZINE [USP-RS]

SULFADIAZINE (EP MONOGRAPH)

SULFADIAZINE (USP IMPURITY)

Sulfadiazine (USP:INN:BAN:JAN)

SULFADIAZINE [EP MONOGRAPH]

SULFADIAZINE [USP IMPURITY]

SULFADIAZINE (USP MONOGRAPH)

SULFADIAZINE [USP MONOGRAPH]

2-Sulfanilamidopyrimidin [German]

A-306 (VAN)

SMR000059113

Sulfadiazine (TN)

N-(2-Pyrimidinyl)sulfanilamide

SULFADIMIDINE IMPURITY B (EP IMPURITY)

SULFADIMIDINE IMPURITY B [EP IMPURITY]

rBPI21 & Sulfa

N1-(Pyrimidin-2-yl)sulfanilamide

SR-01000002973

SSD

2-Sulfanilamido-pyrimidine

diazine

ulfadiazine

CRL-8131 & Sulfadiazine

N1-2-Pyrimidinylsulfanilamide

Sulfadiazine (JAN/USP/INN)

Sulfadiazine Base

Sulfadiazine,(S)

Trisulfapyrimidine, oral suspension

Prestwick_428

Spectrum_000986

Sulfadiazina Reig Jofre

Sulfadiazine (Standard)

Sulfacombin (Salt/Mix)

Prestwick0_000023

Prestwick1_000023

Prestwick2_000023

Prestwick3_000023

Spectrum2_001319

Spectrum3_001362

Spectrum4_000342

Spectrum5_000992

SULFADIAZINE [MI]

[(4-aminophenyl)sulfonyl]pyrimidin-2-ylamine

SULFADIAZINE [INN]

SULFADIAZINE [JAN]

Epitope ID:140083

N1-2-Pyrimidylsulfanilamide

Sulfadiazine, >=99.0%

SULFADIAZINE [VANDF]

Oprea1_081078

SCHEMBL24176

BSPBio_000085

BSPBio_002884

KBioGR_000743

KBioSS_001466

MLS000069423

MLS006011457

720 - Sulfonamides in fish

DivK1c_000543

pyrimidine, 2-sulphanilamido-

SPECTRUM1500546

SULFADIAZINE [WHO-DD]

SPBio_001417

SPBio_002006

BPBio1_000095

WLN: T6N CNJ BMSWR DZ

GTPL12635

HMS501L05

HY-B0273R

KBio1_000543

KBio2_001466

KBio2_004034

KBio2_006602

KBio3_002104

MSK4017

SULFADIAZINE [GREEN BOOK]

NINDS_000543

GLXC-25873

HMS1568E07

HMS1921A13

HMS2090P09

HMS2092I15

HMS2095E07

HMS2235D19

HMS3371L19

HMS3655I10

HMS3712E07

Pharmakon1600-01500546

SULFADIAZINE [ORANGE BOOK]

ALBB-014888

BCP12140

HY-B0273

Tox21_110360

BBL013169

BDBM50166571

CCG-39257

NSC757324

Recombinant bactericidal/permeability-increasing protein & Sulfadiazine

s1770

STK317797

2-(p-Aminobenzenesulfonamido)pyrimidin

AKOS000119073

AS29662

DB00359

KS-1144

NSC-757324

2-(4-Aminobenzenesulfonamido)pyrimidine

4-amino-N-2-pyrimidylbenzenesulfonamide

IDI1_000543

SULFADIAZINE COMPONENT OF SULFOSE

NCGC00016305-02

NCGC00016305-03

NCGC00016305-04

NCGC00016305-05

NCGC00016305-06

NCGC00016305-09

NCGC00016305-10

NCGC00016305-11

NCGC00023291-03

NCGC00023291-04

SULFADIAZINE (TRISULFAPYRIMIDINES)

SULFADIAZINE COMPONENT OF TERFONYL

2-(4-Aminobenzenesulfonylamino)pyrimidine

AC-26817

AS182571

SULFADIAZINE COMPONENT OF LANTRISUL

SULFADIAZINE COMPONENT OF SULFALOID

4-amino-N-2-pyrimidinyl benzenesulfonamide

SBI-0051520.P003

SULFADIAZINE COMPONENT OF NEOTRIZINE

4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline

AB00052095

NS00000198

S0579

Sulfadiazine 1000 microg/mL in Acetonitrile

Sulfadiazine for identification of impurity F

SW196657-3

4-amino-N-(2-pyrimidinyl) benzenesulfonamide

EN300-19076

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide #

C07658

D00587

D92267

SBI-0051520.0001

SULFADIAZINE COMPONENT OF TRIPLE SULFOID

Trisulfapyrimidine, oral suspension (Salt/Mix)

AB00052095-13

AB00052095-14

AB00052095_15

AB00052095_16

Sulfadiazine, VETRANAL(TM), analytical standard

Q2555060

SR-01000002973-2

SR-01000002973-3

BRD-K32273377-001-05-4

BRD-K32273377-001-09-6

BRD-K32273377-001-15-3

BRD-K32273377-001-16-1

BRD-K32273377-001-17-9

4-AMINO-N-(2-PYRIMIDINYL)-1-BENZENESULFONAMIDE

F1657-1720

Sulfadiazine, certified reference material, TraceCERT(R)

TRISULFAPYRIMIDINES (SULFADIAZINE) [ORANGE BOOK]

Z104472626

Sulfadiazine, European Pharmacopoeia (EP) Reference Standard

Sulfadiazine, United States Pharmacopeia (USP) Reference Standard

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide

Sulfadiazine, Pharmaceutical Secondary Standard; Certified Reference Material

141582-64-1

200-685-8

Sulfadiazine for identification of impurity F, European Pharmacopoeia (EP) Reference Standard