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Puromycin

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Identification
Molecular formula
C22H29N7O5
CAS number
58-58-2
IUPAC name
4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide
State
State
At room temperature, Puromycin is in a solid state.
Melting point (Celsius)
230.00
Melting point (Kelvin)
503.00
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.00
General information
Molecular weight
471.48g/mol
Molar mass
471.4780g/mol
Density
1.5600g/cm3
Appearence

Puromycin is typically a white to off-white powder.

Comment on solubility

Solubility Overview of 4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide (C22H29N7O5)

The solubility of 4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide can be influenced by various factors due to its complex structure. Here's a detailed look at its solubility characteristics:

  • Solvents: The compound is expected to be more soluble in polar solvents, such as water and methanol, due to the presence of multiple hydroxyl groups, which can form hydrogen bonds with the solvent.
  • pH Sensitivity: The solubility can also be affected by the pH of the solution. In acidic conditions, the solubility might increase due to protonation of the amine groups, enhancing interaction with the solvent.
  • Temperature Dependency: An increase in temperature generally leads to increased solubility for many organic compounds; however, this may vary based on the specific interactions present in this compound.
  • Molecular Structure Impact: The presence of a carboxamide group may also contribute to its solubility, whereas hydrophobic regions could negatively impact solubility in nonpolar solvents.

In summary, the solubility of this compound is multifaceted, heavily influenced by its functional groups and the solvent used. As with many similar compounds, it's critical to conduct specific solubility tests to determine its behavior in various environments for practical application.

Interesting facts

Interesting Facts about 4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide

4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide is a fascinating compound that intersects various fields of chemical research, especially in medicinal chemistry and pharmaceutical applications. Here are some notable insights:

  • Biological Significance: This compound is particularly intriguing due to its potential role as a therapeutic agent. Its structural motifs suggest that it may have interactions at a molecular level that could be beneficial in treating certain diseases.
  • Synthetic Pathways: The synthesis of this compound showcases the application of complex organic synthesis strategies, demonstrating how intricate molecules can be crafted from simpler precursors through multiple steps, including the formation of glycosidic and heterocyclic bonds.
  • Structure-Activity Relationship (SAR): The presence of both amino and carbohydrate-like structures indicates that it could participate in various biological interactions. Researchers are often keen on understanding how modifications to the structure might enhance biological activity or reduce toxicity where necessary.
  • Potential Applications: Due to its unique functional groups, there is ongoing research into its use as a potential anti-cancer agent. Notably, compounds with pyrimidine and pyrrole cores have been found to exhibit significant biological activity.
  • Multifaceted Approach: The compound's structure allows for the exploration of its behavior through various analytical techniques. These might include NMR spectroscopy for structural confirmation, as well as mass spectrometry for understanding fragmentation patterns.

In the realm of pharmaceutical chemistry, understanding compounds like this one is essential for the development of new therapeutic strategies. As a researcher or student, delving into the complex world of such molecules can provide invaluable insight into the intricate balance between structure and function.

As one scholar aptly noted, “The magic of chemistry lies in its ability to create compounds that can change lives.” Indeed, this compound exemplifies that sentiment and underscores the promise that lies within the world of organic synthesis and drug development.

Synonyms
Antibiotic B 14437 (base)
90813-74-4
4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide
NSC65346
Sauzivamycin
MLS000517268
MLS002703016
SKI 27013
B 90912
SMR000127424
4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrate
Neuro_000028
Neuro_000078
CHEMBL328834
SCHEMBL12284269
BDBM32338
cid_9549170
DTXSID30920146
BCP32776
NSC134339
NSC-134339
NCGC00247059-01
NCI60_000957
NCI60_018656
SMR001566824
DB-044520
F82268
Z3291119633
4-Amino-7-pentofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboximidic acid
4-amino-7-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrate
4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-pyrrolo[2,3-d]pyrimidinecarboxamide;hydrate
4-azanyl-7-[5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrate