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Fluorophenamic acid

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Identification
Molecular formula
C22H28ClFN2O4
CAS number
.893-57-1
IUPAC name
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidyl]-2-methoxy-benzamide
State
State

At room temperature, Fluorophenamic acid is a solid. It is typically stored in a dry, cool place, and handled as a powder or crystalline solid.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
530.00
Boiling point (Kelvin)
803.15
General information
Molecular weight
485.51g/mol
Molar mass
485.5100g/mol
Density
1.3000g/cm3
Appearence

Fluorophenamic acid is typically a white to off-white crystalline solid. It may appear as a powder or in crystalline form with a fine texture.

Comment on solubility

Solubility of 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidyl]-2-methoxy-benzamide

The solubility of the compound 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidyl]-2-methoxy-benzamide (C22H28ClFN2O4) can be influenced by several factors:

  • Polarity: The presence of functional groups such as amines and methoxy groups suggests varying degrees of polarity, which can affect its solubility in polar versus nonpolar solvents.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the amino and methoxy groups can enhance solubility in polar solvents, particularly water.
  • Van der Waals Forces: The aromatic rings present in the structure may exhibit hydrophobic interactions leading to decreased solubility in highly polar solvents.

In general, the solubility of this compound can be summarized as follows:

  1. If the compound is dissolved in organic solvents such as DMSO or ethanol, it may exhibit better solubility due to the nonpolar regions.
  2. In aqueous solutions, the solubility may be limited due to the bulkiness of the molecule and hydrophobic characteristics from the aromatic groups.

In conclusion, the solubility of C22H28ClFN2O4 is a complex interplay of structural characteristics, where polarity, hydrogen bonding, and molecular interactions play crucial roles in determining its behavior in various solvents.

Interesting facts

Interesting Facts about 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidyl]-2-methoxy-benzamide

This complex compound, often discussed in the field of medicinal chemistry, is notable for its potential applications in pharmaceutical research. Here are some fascinating insights:

  • Targeted Action: The unique structure of this compound suggests it may act on specific biological pathways, making it of interest in the development of targeted therapies.
  • Piperidine Moiety: The inclusion of a piperidine ring is a common motif in various bioactive compounds, often enhancing their ability to interact with biological targets.
  • Fluorine Substitution: The presence of fluorine atoms can modify the compound's lipophilicity, which may influence its pharmacokinetic properties, potentially aiding in blood-brain barrier penetration—a crucial factor in neuropharmacology.
  • Amino Group Benefits: Amino groups are known to enhance solubility and bioavailability, which are essential characteristics for the efficacy of therapeutic agents.

Moreover, the compound's multi-faceted design allows for various functional group modifications, which could lead to the development of derivatives with improved activity or reduced side effects. As a result, compounds like this one are often at the forefront of research in drug discovery, enabling scientists to understand better how structural changes can affect biological function.

In the words of one researcher, "The complexity of synthesis in compounds like this reflects the intricate relationship between chemistry and biology, where even minor modifications can yield significant therapeutic impacts."

Continued study in this realm is crucial, not only for advancing specific therapies but also for unveiling new medicinal applications and enhancing our overall understanding of chemical interactions within biological systems.

Synonyms
cisapride
Propulsid
81098-60-4
104860-73-3
Acenalin
Propulsin
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
Risamal
4-AMINO-5-CHLORO-N-{1-[3-(4-FLUOROPHENOXY)PROPYL]-3-METHOXY-4-PIPERIDYL}-2-METHOXYBENZAMIDE
T 1341
4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
(+/-)-Cisapride
DTXCID402825
Cisapride?
NCGC00016944-01
4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
4-Amino-5-Chloro-N-{1-[3-(4-Fluorophenoxy)Propyl]-3-Methoxy-4-Piperidinyl}-2-Methoxybenzamide
Benzamide, 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxy-, cis-
Benzamide, 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, cis-
Prestwick_786
CAS-81098-60-4
Cisapride (USP/INN)
(.+/-.)-Cisapride
Prestwick0_000430
Prestwick1_000430
Prestwick2_000430
CHEMBL1729
SCHEMBL16131
GTPL240
SPBio_002359
CHEBI:95129
cid_5311047
HMS1569E22
HMS3370F16
KBC97069
Tox21_110699
BDBM50005836
STL058624
AKOS005710823
Tox21_110699_1
AC-1912
CCG-213491
NCGC00025262-02
NCGC00168465-01
4-amino-5-chloro-N-[1-{3-[(4-fluorophenyl)oxy]propyl}-3-(methyloxy)piperidin-4-yl]-2-(methyloxy)benzamide
LS-15011
NS00003210
C06910
D00274
L000938
BRD-A12896037-001-02-7
BRD-A12896037-001-04-3
4-Amino-5-chloro-N-(1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl)-2-methoxybenzamide, cis- #