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Baclofen

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Identification
Molecular formula
C10H12ClNO2
CAS number
1134-47-0
IUPAC name
4-amino-3-(4-chlorophenyl)butanoic acid
State
State

At room temperature, Baclofen is in solid form.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
213.66g/mol
Molar mass
213.6610g/mol
Density
1.2918g/cm3
Appearence

Baclofen is a white to off-white, odorless or practically odorless crystalline powder.

Comment on solubility

Solubility of 4-amino-3-(4-chlorophenyl)butanoic acid (C10H12ClNO2)

The solubility of 4-amino-3-(4-chlorophenyl)butanoic acid is influenced by several factors that can enhance or hinder its dissolving capabilities.

Factors Affecting Solubility

  • Polarity: The presence of both an amino group (-NH2) and a carboxylic acid group (-COOH) in its structure increases the polarity of this compound. This sometimes enhances its solubility in polar solvents, such as water.
  • Hydrophobic Moiety: The 4-chlorophenyl group introduces a hydrophobic character that can decrease overall solubility in aqueous environments. This dual character creates a complex balance in solubility.
  • pH Sensitivity: The solubility can vary significantly with pH, particularly due to the carboxylic acid group, which can ionize under alkaline conditions, affecting the compound's ability to dissolve.

General Insights

In conclusion, while 4-amino-3-(4-chlorophenyl)butanoic acid may exhibit some solubility in water, it is not exceedingly soluble. Depending on the solvent conditions and pH, effective solubility may fluctuate, establishing this compound as an interesting subject for further study in pharmaceutical chemistry.

Interesting facts

Interesting Facts about 4-Amino-3-(4-Chlorophenyl)butanoic Acid

4-Amino-3-(4-chlorophenyl)butanoic acid, commonly referred to as a derivative of amino acid structures, plays a significant role in various biochemical applications and research areas. Here are some engaging facts about this compound:

  • Biochemical Importance: This compound is recognized for its potential involvement in neurotransmitter synthesis and modulation. Its structural similarity to the amino acid glutamate indicates a possible role in neurobiological processes.
  • Pharmacological Potential: 4-amino-3-(4-chlorophenyl)butanoic acid has attracted interest for its potential therapeutic applications, particularly in the field of neuropharmacology. It may exhibit modulatory effects on receptor activity, paving the way for novel drug development.
  • Research Applications: This compound serves as a crucial intermediate in synthetic organic chemistry, facilitating the formation of more complex structures. Its importance in the chemical industry cannot be overstated, as it supports research in medicinal chemistry.
  • Environmental Considerations: As with many chemical compounds, understanding the environmental impact of 4-amino-3-(4-chlorophenyl)butanoic acid is essential. Studies may focus on its degradation pathways and potential ecological effects if released into the environment.
  • Cultural Significance: The study of amino acid derivatives like this compound extends to the realm of nutrition and dietary supplements, emphasizing their roles in human health and wellness.

In the words of famous chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” This reflects the ongoing exploration of compounds like 4-amino-3-(4-chlorophenyl)butanoic acid in both academic and industrial settings as researchers continue to uncover their myriad applications and benefits.


By diving deeper into the properties and behaviors of such compounds, scientists are not only enhancing our understanding of biochemical processes but also contributing to the advancement of innovative therapeutic solutions.

Synonyms
baclofen
1134-47-0
Lioresal
4-Amino-3-(4-chlorophenyl)butanoic acid
Baclon
Kemstro
DL-Baclofen
Baclofene
Baclofeno
Gabalon
(+-)-Baclofen
Baclofenum
Baclophen
Lioresal Intrathecal
(RS)-BACLOFEN
beta-(4-Chlorophenyl)gaba
4-Amino-3-(4-chlorophenyl)butyric acid
Gablofen
Ciba 34,647-Ba
(+/-)-BACLOFEN
DL-4-Amino-3-p-chlorophenylbutanoic acid
Ba-34647
beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
C 34647Ba
beta-(p-Chlorophenyl)-gamma-aminobutyric acid
Ba 34647
Baclofene [INN-French]
Baclofenum [INN-Latin]
Baclofeno [INN-Spanish]
Ba-34,647
beta-(Aminomethyl)-p-chlorohydrocinnamic acid
gamma-Amino-beta-(p-chlorophenyl)butyric acid
Baclofen (R,S)
FLEQSUVY
LYVISPAH
CCRIS 3722
Butanoic acid, 4-amino-3-(4-chlorophenyl)-
EINECS 214-486-9
UNII-H789N3FKE8
MFCD00055143
NSC-755906
BRN 2104494
OZOBAX
CHEBI:2972
H789N3FKE8
IPX056
DTXSID5022641
Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-
IPX 056
C10H12ClNO2
CHEMBL701
DTXCID002641
Atrofen
Apo-Baclofen
Chlorophenyl GABA
NSC329137
Baclofen [USAN:USP:INN:BAN:JAN]
NSC 755906
HYDROCINNAMIC ACID, beta-(AMINOMETHYL)-p-CHLORO-
4-Amino-3-(p-chlorophenyl)butyric acid
NCGC00015156-11
Baclofene (INN-French)
Baclofenum (INN-Latin)
(RS)-Amino-3-(4-chlorophenyl)butyric acid
Baclofeno (INN-Spanish)
PCP-GABA
BACLOFEN (MART.)
BACLOFEN [MART.]
BACLOFEN (USP-RS)
BACLOFEN [USP-RS]
.beta.-(Aminomethyl)-p-chlorohydrocinnamic acid
.beta.-(Aminomethyl)-4-chlorobenzenepropanoic acid
GABA, Chlorophenyl
BACLOFEN (EP MONOGRAPH)
BACLOFEN [EP MONOGRAPH]
BACLOFEN (USP MONOGRAPH)
BACLOFEN [USP MONOGRAPH]
Baclofen (USAN:USP:INN:BAN:JAN)
Lioresal (TN)
Kemstro (TN)
SR-01000000107
(+)-Baclofen; (L)-Baclofen
M03BX01
Baclofen; (3RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
baclofen o
MFCD01321057
Baclofen Injection
(y)-Baclofen
Prestwick_85
CAS-1134-47-0
(?)-Baclofen
(R,S)-Baclofen
Lioresal (baclofen)
Baclofen (Standard)
(A+/-)-Baclofen
( inverted exclamation markA)-BACLOFEN
Baclofen (Intrathecal)
Spectrum_000066
BACLOFEN [USAN]
BACLOFEN [INN]
BACLOFEN [JAN]
BACLOFEN [MI]
BACLOFEN [VANDF]
(.+/-.)-Baclofen
(.+/-.)-Baklofen
Prestwick0_000085
Prestwick1_000085
Prestwick2_000085
Prestwick3_000085
Spectrum2_000092
Spectrum3_000310
Spectrum4_000245
Spectrum5_000852
BACLOFEN [WHO-DD]
Biomol-NT_000251
UPCMLD-DP142
4-AMINO-3(4-CHLOROPHENYL)BUTYRIC ACID
B 5399
Lopac0_000163
Oprea1_440627
SCHEMBL19333
BSPBio_000010
BSPBio_001880
KBioGR_000650
KBioSS_000466
Baclofen - Bio-X trade mark
MLS000028480
.beta.-(4-Chlorophenyl)gaba
DivK1c_000001
SPECTRUM1500135
Baclofen (JP18/USP/INN)
Hydrocinnamic acid, .beta.-(aminomethyl)-p-chloro-
SPBio_000044
SPBio_001949
BACLOFEN [ORANGE BOOK]
Benzenepropanoic acid, .beta.-(aminomethyl)-4-chloro-
BPBio1_000012
BPBio1_000750
GTPL1084
BETA-P-CHLOROPHENYL-GABA
(+/-)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
CIBA BA 34647
UPCMLD-DP142:001
BDBM24182
HMS500A03
HY-B0007R
KBio1_000001
KBio2_000466
KBio2_003034
KBio2_005602
KBio3_001380
Baclofen 0.5 mg/ml in Methanol
NINDS_000001
HMS1568A12
HMS1920E21
HMS2091M03
HMS2095A12
HMS3260B07
HMS3712A12
Pharmakon1600-01500135
( inverted question mark)-Baclofen
ALBB-014712
BCP11844
BCP32777
EX-A1378
HY-B0007
Tox21_110090
Tox21_500163
BBL010735
CCG-38910
CX1358
HB0953
NSC755906
s4840
STK535284
AKOS005174692
Tox21_110090_1
AC-4530
DB00181
FB18127
HS-1001
LP00163
MB00475
NSC-329137
SB67382
SDCCGSBI-0050151.P005
4-Amino-3-(4-chlorophenyl)butanoicacid
IDI1_000001
SMP1_000036
NCGC00015156-04
NCGC00015156-05
NCGC00015156-06
NCGC00015156-07
NCGC00015156-08
NCGC00015156-12
NCGC00015156-13
NCGC00015156-15
NCGC00015156-26
NCGC00015156-28
NCGC00023843-03
NCGC00024579-03
NCGC00024579-04
NCGC00024579-05
NCGC00024579-06
NCGC00260848-01
BB166152
SMR000058294
SY023865
SY052300
4-amino-3-(4-chlorophenyl)-butanoic acid
SBI-0050151.P004
(+/-)-Baclofen, >=98% (TLC), solid
4-Amino-3-(4-chlorophenyl)butanoic acid #
AB00051921
B3343
EU-0100163
NS00007882
beta-(4-chlorophenyl)-gamma-aminobutyric acid
Baclofen, 1mg/ml in Acetonitrile/Water : 1/1
D00241
EN300-118715
M01382
(RS)-4-Amino-3-(4-chlorophenyl)buta noic acid
AB00051921_16
(3RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
.beta.-(p-Chlorophenyl)-.gamma.-aminobutyric acid
.gamma.-Amino-.beta.-(p-chlorophenyl)butyric acid
4-Amino-3-(4-chlorophenyl)butyric Acid, Baclofen
L000002
Q413717
SR-01000000107-2
SR-01000000107-4
SR-01000000107-6
SR-01000000107-8
(+/-)-ss-(Aminomethyl)-4-chlorobenzenepropanoic acid
BRD-A84174873-001-05-2
BRD-A84174873-003-07-4
(+/- )-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
Baclofen, British Pharmacopoeia (BP) Reference Standard
Baclofen, European Pharmacopoeia (EP) Reference Standard
F2173-1127
STX209; STX-209; STX 209; D-Baclofen; Arbaclofen
Baclofen Lioresal 4-Amino-3-(4-chlorophenyl)butyric acid
Baclofen, United States Pharmacopeia (USP) Reference Standard
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material
?-(Aminomethyl)-4-chloro-benzenepropanoic acid;?-(Aminomethyl)-p-chlorohydrocinnamic acid;?-(4-Chlorophenyl)-GABA
214-486-9
b-(Aminomethyl)-4-chloro-benzenepropanoic acid;b-(Aminomethyl)-p-chlorohydrocinnamic acid;b-(4-Chlorophenyl)-GABA