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4-Amino-1H-imidazole-5-carboxylic acid

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Identification
Molecular formula
C4H5N3O2
CAS number
7424-82-5
IUPAC name
4-amino-1H-imidazole-5-carboxylic acid
State
State

At room temperature, 4-amino-1H-imidazole-5-carboxylic acid is in a solid state.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.00
Boiling point (Celsius)
258.00
Boiling point (Kelvin)
531.00
General information
Molecular weight
129.10g/mol
Molar mass
129.1030g/mol
Density
1.5000g/cm3
Appearence

4-Amino-1H-imidazole-5-carboxylic acid typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-amino-1H-imidazole-5-carboxylic acid

4-amino-1H-imidazole-5-carboxylic acid, with the chemical formula C4H5N3O2, exhibits interesting solubility properties that can be influenced by various factors.

Key Aspects of Solubility:

  • Water Solubility: This compound is generally soluble in water, which is a beneficial characteristic for biological applications and research purposes.
  • pH Dependency: The solubility can vary depending on the pH of the solution. It is often more soluble in acidic conditions, where protonation can facilitate its dissolution.
  • Solvent Effects: While it is primarily soluble in polar solvents like water, its solubility may be reduced in non-polar organic solvents. The polarity should be considered when selecting solvents for experiments.

In summary, the solubility of 4-amino-1H-imidazole-5-carboxylic acid is influenced by the solvent and its pH level. Understanding these attributes is essential for effective usage in synthesis and biological applications. Always take care to optimize conditions to achieve the desired solubility and stability.

Interesting facts

Interesting Facts about 4-amino-1H-imidazole-5-carboxylic acid

4-amino-1H-imidazole-5-carboxylic acid, often referred to as histidine due to its presence in the amino acid classification, is a fascinating compound that plays a vital role in biological systems. Here are some intriguing points about this compound:

  • Biosynthesis: Histidine is classified as an essential amino acid for humans, meaning it cannot be synthesized by the body and must be obtained through diet.
  • Biological Importance: Histidine is crucial in various biological processes including:
    • Protein synthesis
    • Enzyme activity regulation
    • Assisting in the formation of hemoglobin, which is essential for oxygen transport in the blood.
  • Role in pH Regulation: It has a unique side chain that allows it to function effectively as a buffer in physiological pH, helping maintain the acid-base balance in the body.
  • History: Discovered in 1896 by Fritz Huber, histidine was first isolated from protein hydrolysates and has since been studied extensively in the fields of biochemistry and nutrition.
  • Sources: Histidine can be found in high-protein foods such as:
    • Meat
    • Fish
    • Dairy products
    • Beans
  • Potential Therapeutic Uses: Beyond its dietary importance, histidine is also being researched for potential therapeutic uses, including:
    • Antioxidant properties
    • Immune system support
    • Potential role in anxiety management through histamine regulation.

The versatility of 4-amino-1H-imidazole-5-carboxylic acid not only makes it indispensable in biochemistry but also a subject of ongoing research aimed at unlocking more of its potential benefits.

Synonyms
5-amino-1H-imidazole-4-carboxylic acid
4919-04-4
4-amino-1H-imidazole-5-carboxylic acid
5-aminoimidazole-4-carboxylic acid
5-amino-4-imidazole carboxylate
4-Amino-5-imidazolecarboxylic acid
MFCD09909757
5-AMINO-1H-IMIDAZOLE-4-CARBOXYLICACID
C05516
SCHEMBL71570
4-aminoimidazole-5-carboxylate
5-aminoimidazole-4-carboxylate
CHEBI:28280
DTXSID20274261
4-amino-imidazole-5-carboxylic acid
AKOS006276123
AKOS016009183
AB54857
SY346387
DB-070972
CS-0452931
EN300-93341
C90485
Q27103607