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Zidovudine

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Identification
Molecular formula
C10H13N5O4
CAS number
30516-87-1
IUPAC name
4-amino-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
State
State

Zidovudine is solid at room temperature.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
359.60
Boiling point (Kelvin)
632.75
General information
Molecular weight
267.24g/mol
Molar mass
267.2420g/mol
Density
1.4360g/cm3
Appearence

Zidovudine typically appears as a white, odorless, and crystalline solid.

Comment on solubility

Solubility of 4-amino-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one

The solubility of the compound 4-amino-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one (C10H13N5O4) can be understood through several key factors:

  • Hydrophilicity: The presence of hydroxymethyl groups contributes significantly to its hydrophilic nature, likely facilitating solubility in polar solvents such as water.
  • Amine Group: The amino group (-NH2) enhances solubility due to its ability to form hydrogen bonds with solvent molecules.
  • Structure Influence: The tetrahydrofuran moiety may introduce a degree of flexibility, which can further assist in solvation processes.

However, while the theoretical aspects suggest good solubility in polar solvents, empirical solubility should be verified through experimentation. As one researcher noted, "Practical solubility often varies from theoretical predictions due to complex interactions in solution."
Thus, it is important to consider both the chemical structure and experimental data when evaluating the solubility of this compound.

Interesting facts

Interesting Facts about 4-amino-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one

This intriguing compound, 4-amino-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one, is notable for its structural complexity and potential applications in various fields of science. Here are some engaging insights about this compound:

  • Pharmaceutical Potential: The presence of the pyrimidin-2-one moiety often correlates with biological activity, making this compound a subject of interest in drug discovery. Researchers continue to investigate its efficacy as a potential therapeutic agent.
  • Unique Structural Features: The incorporation of a hydroxymethyl group attached to the tetrahydrofuran ring contributes to its unique three-dimensional structure, which may influence its interaction with biological targets.
  • Synthetic Versatility: The compound can be synthesized through various organic reactions, showcasing the versatility of modern organic synthesis techniques that allow for the tailoring of its functional groups.
  • Research Opportunities: Ongoing studies help in understanding the compound's reactivity and binding characteristics, making it an excellent candidate for various chemical assessments, including structure-activity relationship (SAR) studies.
  • Interdisciplinary Appeal: Beyond medicinal chemistry, this compound may have applications in materials science and biochemistry, thus attracting interest from multiple disciplines.

In conclusion, 4-amino-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one represents a fascinating example of how intricate chemical structures can lead to a diverse array of biological and chemical phenomena. As research progresses, its contributions to science may prove to be significant and multifaceted.

Synonyms
4-amino-1-[5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
NSC606170
2',3'-Dideoxycytidine;ddC;Dideoxycytidine
2?,3?-Dideoxycytidine
CHEMBL18537
SCHEMBL12149465
SCHEMBL21100417
DTXSID60928175
CHEBI:181069
HMS3371L15
HMS3393H18
HMS3655K04
HMS3867I13
2',3'-DIDEOXYCYTIDINE (DDC)
AB01085
LS-13656
NCI60_004652
SY106119
DB-138166
1-[5-(Hydroxymethyl)oxolan-2-yl]-4-imino-1,4-dihydropyrimidin-2-ol
2 inverted exclamation mark ,3 inverted exclamation mark -Dideoxycytidine
4-Amino-1-[tetrahydro-5-(hydroxymethyl)-2-furanyl]-2(1h)-pyrimidinone
790299-36-4