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Zidovudine

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Identification
Molecular formula
C10H13N5O4
CAS number
30516-87-1
IUPAC name
4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
State
State

Zidovudine is a solid at room temperature.

Melting point (Celsius)
123.00
Melting point (Kelvin)
396.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
267.24g/mol
Molar mass
267.2410g/mol
Density
1.3600g/cm3
Appearence

Zidovudine typically appears as a white to beige, crystalline powder. It is practically odorless.

Comment on solubility

Solubility of 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one

The solubility characteristics of the compound 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one (C10H13N5O4) are quite intriguing due to its diverse functional groups which may influence its interactions with solvents.

Some important aspects regarding its solubility include:

  • Polarity: The presence of hydroxyl (-OH) groups typically increases the polarity of the compound, suggesting enhanced solubility in polar solvents such as water.
  • Functional Groups: The amino group (-NH2) in the structure can facilitate hydrogen bonding with solvents, potentially increasing solubility.
  • Molecular Weight: With a molecular weight of 253.24 g/mol, its relatively low weight may indicate a tendency for better solubility compared to larger compounds.

It is important to note that the solubility may be particularly affected by pH levels and temperature, leading to varying solubility profiles in different environments. A quote often shared in the scientific community states, "The characteristics of solubility are just as fluid as the liquids themselves." This perfectly encapsulates the behavior of compounds like this one.

In conclusion, one might expect 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one to demonstrate significant solubility in polar solvents, with various factors contributing to its overall solubility profile.

Interesting facts

Interesting Facts about 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one

This compound, often abbreviated as a complex nucleotide derivative, holds intrigue for both medicinal chemists and biochemists due to its unique structure and potential applications. Here are some fascinating aspects:

  • Structural Complexity: The presence of multiple functional groups, such as amino and hydroxymethyl moieties, highlights the compound's rich chemical reactivity.
  • Potential Biological Role: Compounds of this nature may play a significant role in biochemical pathways, potentially acting as inhibitors or modulators in various enzymatic reactions.
  • Drug Development: The structural components suggest that it might be a candidate for developing new therapeutic agents, particularly in the field of antiviral or anticancer drugs.
  • Field of Study: It's relevant in research areas exploring nucleotide analogs, which can provide insight into nucleic acid metabolism and function.
  • Research Applications: The synthesis of this compound can aid in the study of protein-nucleotide interactions, which are crucial for understanding cellular mechanisms.

As stated by many researchers, "The design of small molecules that can influence biological systems is one of the most exciting challenges in chemistry." With compounds like this, we can unlock new pathways to curing diseases and enhancing our understanding of life at the molecular level.

Overall, the study of 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one offers a glimpse into the innovation that lies at the intersection of chemistry and biology.

Synonyms
Cytosine deoxyribonucleoside
2'-Deoxy-a-cytidine
4-amino-1-(2-deoxypentofuranosyl)pyrimidin-2(1H)-one
4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
Desoxycytidine
2'-DEOXY-L-CYTIDINE
Cytosine deoxy nucleoside hydrochloride
4449-40-5
3h-deoxycytidine
4-amino-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
2 inverted exclamation mark -Deoxycytidine
bmse000323
TimTec1_003892
NCIOpen2_004589
Oprea1_381403
Oprea1_817993
MLS001183806
CHEMBL280428
SCHEMBL6676882
SCHEMBL10238960
DTXSID00862483
CKTSBUTUHBMZGZ-UHFFFAOYSA-N
HMS2231K21
HMS3374L10
ALBB-025026
BBL002243
MFCD00066875
STK029880
AKOS002315137
AKOS016368361
4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
SMR000677924
SY066621
NS00014659
EN300-7382574
AN-329/06055034
Cytidine, 2'-deoxy-, monohydrochloride (8CI 9CI)
Cytosine, 1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-
F3096-1697
2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-
4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone
4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
7060-91-5