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Thymidine

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Identification
Molecular formula
C10H14N2O5
CAS number
50-89-5
IUPAC name
4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)-2,3,4,5-tetramethyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-one
State
State

At room temperature, thymidine is a solid.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.20
Boiling point (Celsius)
340.30
Boiling point (Kelvin)
613.50
General information
Molecular weight
242.23g/mol
Molar mass
242.2290g/mol
Density
1.5650g/cm3
Appearence

Thymidine appears as a white, crystalline solid. It is odorless and soluble in water. The solid crystals have a characteristic clean and sharp appearance, typical of many organic small molecules.

Comment on solubility

Solubility of 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)-2,3,4,5-tetramethyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-one

The solubility of 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)-2,3,4,5-tetramethyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-one (C10H14N2O5) is influenced by several factors, primarily its chemical structure and the presence of functional groups. This compound exhibits properties that could affect its solubility characteristics as follows:

  • Hydroxyl Groups: The presence of hydroxy (-OH) groups in the compound tends to enhance solubility in polar solvents, particularly water.
  • Pyrimidine Ring: This aromatic structure can introduce significant interaction with varied solvents, often impacting solubility in organic solvents.
  • Hydroxymethyl Substituent: This functional group can improve solubility due to its polar nature, further interacting with solvents.

Overall, solubility is expected to be moderate in water, given the competing hydrophobic regions of the molecule balanced by the polar functional groups. It is essential to note that:

  1. Solubility may increase in organic solvents due to the less polar components of the structure.
  2. Temperature and pH can also play a crucial role in the solubility of this compound.

In summary, while 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)-2,3,4,5-tetramethyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-one is likely to have reasonable solubility due to its mix of functional groups, its behavior in different solvents warrants experimental investigation for precise determination.

Interesting facts

Interesting Facts about 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)-2,3,4,5-tetramethyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-one

This compound, a notable member of the pyrimidine family, contains a unique arrangement of functional groups that grants it intriguing properties and potential applications in various fields. Here are some fascinating aspects of this compound:

  • Structural Complexity: The molecule features both a pyrimidinone ring and a tetrahydrofuran moiety, showcasing a blend of heterocycles that can lead to versatile chemical behavior.
  • Biological Activity: Compounds with similar structures have been studied for their biological activities, including antimicrobial and antitumor effects. This molecule may hold promise for future pharmaceutical research.
  • Hydroxymethyl Group: The presence of a hydroxymethyl group not only influences the reactivity of the molecule but can also enhance solubility and interact favorably in biological systems.
  • Potential as a Drug Candidate: With its unique structure, this compound may serve as a lead compound in drug development, particularly for diseases where pyrimidine derivatives have shown efficacy.
  • Natural Inspirations: Many synthetic compounds are inspired by nature; this compound’s structure suggests it might share attributes with naturally occurring molecules, potentially leading to innovative biosynthetic pathways.

In the world of organic chemistry, compounds like 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)-2,3,4,5-tetramethyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-one exemplify the intricate balance between chemical structure and biological function.

As noted by researchers, "The exploration of diverse heterocycles opens new avenues for drug discovery and complex synthetic methodologies." This statement underscores the importance of studying compounds with robust and elaborate architectures like this one.