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Prazosin

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Identification
Molecular formula
C19H21N5O4
CAS number
19237-84-4
IUPAC name
[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone
State
State

At room temperature, Prazosin is a solid compound.

Melting point (Celsius)
278.00
Melting point (Kelvin)
551.15
Boiling point (Celsius)
516.00
Boiling point (Kelvin)
789.15
General information
Molecular weight
383.41g/mol
Molar mass
383.4180g/mol
Density
1.3500g/cm3
Appearence

Prazosin is typically encountered as a white to off-white, crystalline powder. It is known for its characteristic crystalline structure when purified.

Comment on solubility

Solubility of [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone (C19H21N5O4)

Understanding the solubility of a compound is crucial for predicting its behavior in various environments and applications. For the compound [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone, the solubility can be influenced by several factors:

  • Polarity: The presence of amino and methoxy groups suggests potential for strong interactions with polar solvents such as water.
  • Hydrogen Bonding: The ability of the amino group to form hydrogen bonds may enhance solubility in polar solvents.
  • Molecular Size: The size and complexity of the bicyclic structure might hinder solubility in certain organic solvents.
  • pH Dependence: The solubility may vary with pH, especially for compounds containing amine functionalities.

In practical terms, this compound is likely to exhibit varying solubility characteristics depending on the solvent system. For example, it may dissolve well in:

  1. Water: due to the polar nature of its functional groups.
  2. Dimethyl sulfoxide (DMSO): known for dissolving a wide range of organic and inorganic compounds.
  3. Alcohols: such as ethanol or methanol, as they can interact favorably with the methoxy groups.

However, it might face challenges achieving sufficient solubility in nonpolar solvents, limiting its applicability in certain scenarios. Thus, a thorough solubility study is essential for fully understanding how this compound can be utilized in medicinal chemistry or other fields.

Interesting facts

Exploring [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone

This compound is a fascinating example of modern medicinal chemistry, particularly due to its structural complexity and potential pharmacological applications. Here are some interesting facts:

  • Quinazoline Derivative: The compound contains a quinazoline moiety, which plays a significant role in drug design. Quinazolines are known for their diverse biological activities, including anticancer, antimicrobial, and antiviral effects.
  • Piperazine Linker: The presence of a piperazine group contributes to the compound’s ability to interact with various biological targets, enhancing its pharmacodynamics.
  • Unique Bicyclic Structure: The bicyclo[2.2.2]octane framework introduces strain, which can stabilize or influence the bioactivity of the compound significantly.
  • Potential Therapeutic Uses: Given its unique structure, this compound is being researched for use in treatments against a variety of conditions, including but not limited to cancer and neurological disorders.

The intricate balance of the piperazine and quinazoline elements within this compound showcases the intricate relationship between chemical structure and biological function. As noted by many chemists, "The structure of a molecule is the key to unlocking its potential." This statement holds particularly true for compounds with complex architectures like [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone, which push the boundaries of our understanding of molecular interactions in pharmaceuticals.

Research continues to unfold the potential of such compounds in developing new therapeutic agents, highlighting the continual need for innovation in the field of drug discovery.

Synonyms
Prazobind
107021-36-3
Szl 49
Szl-49
Methanone,[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]bicyclo[2.2.2]octa-2,5-dien-2-yl-
CHEMBL429379
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-bicyclo(2.2.2)octa-2,5-dienylcarbonyl)piperazine
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(bicyclo(2.2.2)octa-2,5-dien-2-ylcarbonyl)-
DTXSID80910214
BDBM50227880
AKOS030255794
FP27127
DB-225333
HY-118335
CS-0065710
L003498
(Bicyclo[2.2.2]octa-2,5-dien-2-yl)[4-(4-imino-6,7-dimethoxy-3,4-dihydroquinazolin-2-yl)piperazin-1-yl]methanone
[4-(4-Amino-6,7-Dimethoxyquinazolin-2-Yl)Piperazin-1-Yl]-(6-Bicyclo[2.2.2]Octa-2,5-Dienyl)Methanone
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-bicyclo[2.2.2]octa-2,5-dienyl-carbonyl)-piperazine;SZL-49
2-(4-{bicyclo[2.2.2]octa-2,5-diene-2-carbonyl}piperazin-1-yl)-6,7-dimethoxyquinazolin-4-amine