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Sertraline

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Identification
Molecular formula
C17H17Cl2N
CAS number
79617-96-2
IUPAC name
4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine
State
State

At room temperature, sertraline is generally in a solid state as its hydrochloride salt form, which is how it is often used pharmaceutically.

Melting point (Celsius)
246.00
Melting point (Kelvin)
519.15
Boiling point (Celsius)
533.50
Boiling point (Kelvin)
806.65
General information
Molecular weight
306.23g/mol
Molar mass
306.2300g/mol
Density
1.2000g/cm3
Appearence

Sertraline is typically a white to off-white crystalline powder. It can vary slightly in appearance based on its form and specific manufacturing processes.

Comment on solubility

Solubility of 4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine (C17H17Cl2N)

The solubility of 4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine is an intriguing subject due to its chemical structure and properties. Here are some key points to consider:

  • Polar vs. Nonpolar: This compound contains chlorine atoms, which can impart some polar characteristics. However, it also has a relatively large hydrocarbon backbone, suggesting that it may exhibit nonpolar behavior.
  • Common Solvents: Compounds such as this one are typically soluble in organic solvents like:
    • Chloroform
    • Dichloromethane
    • Acetone
    Yet, it is likely to have poor solubility in polar solvents like water.
  • Temperature Effects: Generally, an increase in temperature can enhance solubility for many organic compounds, including this one, making hot solvents a potential avenue for increased dissolution.
  • pH Influence: The presence of an amine group suggests that this compound may behave favorably in basic conditions where protonation can increase solubility.

In summary, while 4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine may demonstrate some level of solubility in certain organic solvents, its overall solubility profile will depend heavily on the medium's polarity, temperature, and pH conditions. As with many compounds, a thorough investigation remains paramount to fully understand the solubility characteristics.

Interesting facts

Interesting Facts about 4-(3,4-Dichlorophenyl)-N-methyl-tetralin-1-amine

4-(3,4-Dichlorophenyl)-N-methyl-tetralin-1-amine, often referred to in the scientific community as a member of the amine family, presents a unique chemical structure that has garnered interest for several reasons:

  • Pharmacological Potential: This compound is notable for its potential applications in therapeutic settings. It can act as a substrate for various receptors in the brain, leading to research in areas of neuropharmacology.
  • Structural Insights: The presence of dichlorophenyl groups introduces intriguing properties that can enhance the lipophilicity of the compound, which could influence its interaction with biological membranes.
  • Research Utility: As a synthetic organic molecule, it serves as a useful tool in various chemical synthesis experiments, providing insights into substitution patterns and reactivity patterns characteristic of amines.
  • Environmental Impact: Investigations are ongoing regarding the environmental persistence of compounds containing halogens like chlorine, including the potential for bioaccumulation and its effects on ecosystems.
  • Structure-Activity Relationships: The study of this compound encourages scientists to explore the relationships between its molecular structure and biological activity, which is crucial for drug development.

In summary, 4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine embodies an exciting intersection of organic chemistry and pharmacology, presenting various avenues for exploration. As researchers delve deeper into its properties and potential applications, it may pave the way for significant advancements in medicine and environmental science.

Synonyms
140631-53-4
4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
4(3,4-DICHLOROPHENYL) 1,2,3,4 TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE
(R,R)-Sertraline
1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-
Zoloft (Salt/Mix)
MolMap_000056
SCHEMBL137619
CHEMBL190573
SCHEMBL14028076
BDBM86421
DTXSID00861017
HMS3372K14
EDA61798
4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine
NSC_68617
1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-
4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenamine
AKOS015911986
AB25163
CAS_79617-96-2
DB-105907
1-methylamino-4-(3,4-dichlorophenyl)tetralin
EN300-296116
L000801
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine
4(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine racemate
racemic N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine