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Diclofenac

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Identification
Molecular formula
C14H13Cl2NO2
CAS number
15307-79-6
IUPAC name
4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid
State
State

Diclofenac is a solid at room temperature, typically appearing as a crystalline powder.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
327.50
Boiling point (Kelvin)
600.65
General information
Molecular weight
296.15g/mol
Molar mass
296.1480g/mol
Density
1.5656g/cm3
Appearence

Diclofenac typically appears as a white to slightly yellowish crystalline powder. It is practically insoluble in water but soluble in organic solvents.

Comment on solubility

Solubility of 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid

The solubility of 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid (C14H13Cl2NO2) is influenced by several factors relating to its chemical structure. Understanding solubility is crucial for its applications in various fields, including pharmaceuticals and chemical synthesis. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple functional groups, including the amino and carboxylic acid moieties, can impart polarity to the molecule, enhancing its solubility in polar solvents like water.
  • Hydrophobicity: The dipentylamino group contributes significant hydrophobic properties, which may decrease solubility in aqueous environments.
  • Temperature Dependency: As is common with many compounds, solubility can increase with temperature; therefore, studying this compound at various temperatures could provide insights into its solubility profile.
  • pH Sensitivity: The solubility of carboxylic acids is significantly affected by pH. Under acidic conditions, the compound may remain protonated, while at higher pH levels, deprotonation could increase solubility.

In general, this compound tends to have limited aqueous solubility owing to its relatively complex structure. As encapsulated by the statement, "Solubility is a dance between the polar and non-polar aspects of a molecule." Thus, while it may dissolve in polar organic solvents, its solubility in water could be restricted, necessitating further investigation to optimize its use in various applications.

Interesting facts

Interesting Facts about 4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid

This compound, often referred to as a part of the class of amino acid derivatives, demonstrates a fascinating interplay of structural features that contribute to its unique properties and potential applications. Here are some key highlights:

  • Chemical Structure: The presence of a dichlorobenzoyl group combined with an amino acid backbone illustrates the complexity that can arise in organic molecules. This intricate design may contribute to varied biological activities.
  • Potential Applications: Compounds like this one can serve as valuable intermediates in the synthesis of pharmaceuticals, especially in drug design. Their unique structures may allow for interactions with specific biological targets.
  • Biological Significance: Amino acids and their derivatives are essential in biological systems; understanding their behavior can reveal insights into metabolic pathways and enzymatic reactions.
  • Research Importance: The incorporation of halogens, such as chlorine, into molecular structures has been shown to significantly enhance biological activity, making compounds like this of particular interest in medicinal chemistry.
  • Environmental Considerations: With the growing focus on environmentally friendly chemistry, studying halogenated derivatives is crucial, as they can exhibit varying degrees of environmental persistence.

As noted in scientific literature, "the modification of amino acid structures can lead to derivatives with enhanced properties that are crucial for drug development." The exploration of compounds like 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid not only broadens our understanding of chemical interactions but also opens doors to innovations in health and technology.

Synonyms
Lorglumide
97964-56-2
Lorglumide [INN]
Lorglumida
CR-1409
LAD1UQ73BE
CHEMBL24938
CHEBI:88307
4-(3,4-dichlorobenzamido)-5-(dipentylamino)-5-oxopentanoic acid
4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic acid
Lorglumidum [Latin]
Lorglumida [Spanish]
Lorglumidum
4-((3,4-dichlorobenzoyl)amino)-5-(dipentylamino)-5-oxopentanoic acid
Pentanoic acid,4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-
CCRIS 6857
UNII-LAD1UQ73BE
DL-4-(3,4-Dichlorobenzoylamino)-5-(dipentylamino)-5-oxopentanoic Acid; 4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic Acid; CR 1409; (+/-)-4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic Acid; 4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic Acid
Spectrum_001628
Prestwick0_000915
Prestwick1_000915
Prestwick2_000915
Prestwick3_000915
D,L-4-(3,4-Dichlorobenzoylamino)-5-(dipentylamino)-5-oxo-pentanoic acid
Lopac0_000731
BSPBio_000790
GTPL891
KBioSS_002108
4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-butyric acid
SCHEMBL149509
SPBio_002979
BPBio1_000870
DTXSID2046961
KBio2_002108
KBio2_004676
KBio2_007244
(+-)-4-(3,4-Dichlorobenzamido)-N,N-dipentylglutaramic acid
HMS2090O20
BDBM50008170
MFCD00083183
PDSP1_000881
PDSP2_000867
FL43268
SDCCGSBI-0050709.P003
Pentanoic acid, 4-((3,4-dichlorobenzoyl)amino)-5-(dipentylamino)-5-oxo-, (+-)-
SBI-0050709.P002
NS00122184
AB01275506-01
L000350
BRD-A29854054-236-03-5
BRD-A29854054-236-07-6
BRD-A29854054-236-12-6
Q12745785
N(2)-(3,4-dichlorobenzoyl)-N,N-dipentyl-alpha-glutamine
(+/-)-4-(3,4-DICHLOROBENZAMIDO)-N,N-DIPENTYLGLUTARAMIC ACID
(+/-)-4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic acid sodium salt
DL-4-(3,4-DICHLOROBENZOYLAMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID
PENTANOIC ACID, 4-((3,4-DICHLOROBENZOYL)AMINO)-5-(DIPENTYLAMINO)-5-OXO-