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Alprazolam

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Identification
Molecular formula
C17H13ClN4
CAS number
28981-97-7
IUPAC name
4-[3-(cyclopropylmethyl)-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine
State
State

Alprazolam is in a solid state at room temperature. It is usually encountered in its pill or tablet form when used pharmaceutically.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
519.24
Boiling point (Kelvin)
792.39
General information
Molecular weight
308.77g/mol
Molar mass
308.7650g/mol
Density
1.3180g/cm3
Appearence

Alprazolam is a white, crystalline powder, and it is odorless. In its pure form, it is typically supplied as a solid.

Comment on solubility

Solubility of 4-[3-(cyclopropylmethyl)-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine

The solubility of the compound with the formula C17H13ClN4, known for its distinctive structure, can be influenced by several factors. Typically, compounds with multiple functional groups such as this one can exhibit diverse solubility characteristics:

  • Polarity: The presence of polar nitrogen atoms in the imidazole and pyrimidine rings can enhance solubility in polar solvents.
  • Hydrophobic Interactions: The cyclopropyl and fluorophenyl groups introduce hydrophobic characteristics, which may limit solubility in aqueous environments.
  • pH Dependence: The solubility may also vary with pH, particularly due to the basicity of the amine, potentially leading to different solubility profiles in acidic versus basic solutions.
  • Solvent Choice: It is essential to consider the choice of solvent; organic solvents such as DMSO, methanol, or acetonitrile may provide better solubility compared to water.

In practice, one can say:

“Optimizing solvent conditions is key to maximizing the solubility of this compound.”

Overall, while experimental data are necessary to ascertain the precise solubility levels, understanding these influencing factors is crucial for applications involving this compound.

Interesting facts

Interesting Facts about 4-[3-(cyclopropylmethyl)-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine

This intriguing compound, known for its unique molecular structure, stands out in the realm of pharmaceuticals and medicinal chemistry. Here are some fascinating insights:

  • Targeted Therapy: This compound plays a significant role in the development of targeted therapies, particularly in oncology, where imidazole and pyrimidine derivatives are often explored for their efficacy against various cancer types.
  • Fluorine's Role: The presence of the 4-fluorophenyl group enhances the compound's ability to interact with biological targets, potentially increasing the potency and selectivity of the drug.
  • Cyclopropylmethyl Group: The addition of the cyclopropylmethyl moiety is not just for structural uniqueness; it can introduce significant activity by affecting binding interactions and molecular stability.
  • Research Applications: This compound has become a subject of various studies aimed at understanding its biological activity, serving as a useful lead compound in medicinal chemistry.

In the words of a renowned chemist, "The beauty of molecular design lies in how small modifications can lead to profound changes in biological activity." This compound exemplifies that principle, showcasing how thoughtful structural modifications can enhance therapeutic properties.

Overall, the exploration of compounds like this one contributes significantly to advancements in drug discovery and development, illuminating pathways to effective treatments that better target diseases while minimizing off-target effects.

Synonyms
165806-51-9
1bmk
4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE
SB-218655
4-[3-(cyclopropylmethyl)-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine
R37TCQ1HFT
4-(1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyrimidin-2-amine
4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1h-imidazol-5-yl]pyrimidin-2-amine
SB 218655
4-(3-(Cyclopropylmethyl)-5-(4-fluorophenyl)imidazol-4-yl)pyrimidin-2-amine
C14316
2-Pyrimidinamine, 4-(1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-
UNII-R37TCQ1HFT
CHEMBL590753
SCHEMBL4323457
BDBM15238
DTXSID50274456
sb218655
DB03980
SB5
DB-380279
NS00068983
Q27094839
4-[1-(Cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine