Skip to main content

Sertindole

ADVERTISEMENT
Identification
Molecular formula
C24H26N4O2
CAS number
106516-24-9
IUPAC name
4-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxy-propoxy]-1H-indole-2-carbonitrile
State
State

At room temperature, sertindole is in a solid state, specifically a crystalline powder, which is typical for many pharmaceutical compounds. It is generally stable under normal conditions of temperature and pressure.

Melting point (Celsius)
239.30
Melting point (Kelvin)
512.45
Boiling point (Celsius)
457.90
Boiling point (Kelvin)
731.05
General information
Molecular weight
440.57g/mol
Molar mass
440.5700g/mol
Density
1.3000g/cm3
Appearence

Sertindole is typically supplied as a white to off-white crystalline powder. It may appear slightly different based on the form and manufacturer, but it generally does not have any distinctive color or sheen when in its pure state.

Comment on solubility

Solubility Profile of 4-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxy-propoxy]-1H-indole-2-carbonitrile

The solubility of the compound C24H26N4O2 can be quite complex due to its intricate molecular structure. Here are some important considerations:

  • Hydrophobic versus Hydrophilic Characteristics: The presence of a benzhydryl group indicates significant hydrophobicity, which can lead to decreased solubility in water. However, the inclusion of a hydroxyl group (-OH) can impart some hydrophilic properties, enhancing solubility in polar solvents.
  • Solvent Dependence: Typically, such compounds may show enhanced solubility in organic solvents. For instance, solvents like:
    • DMSO (Dimethyl sulfoxide)
    • Ethyl acetate
    • Methanol
    are often able to dissolve this type of compound more readily.
  • pH Effects: The solubility can also vary with changes in pH. If the compound behaves as a weak acid or base, its ionization in solution may significantly influence its solubility.
  • Temperature Influence: Increased temperature can often enhance solubility, making thermal conditions a critical factor during solubility assessments.

In conclusion, the solubility of C24H26N4O2 is influenced by various factors, leading to variability based on solvent choice, temperature, and other environmental conditions. Hence, experimentation is essential for definitive solubility profiles.

Interesting facts

Interesting Facts about 4-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxy-propoxy]-1H-indole-2-carbonitrile

4-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxy-propoxy]-1H-indole-2-carbonitrile, often just referred to as a complex indole derivative, has captured the interest of researchers due to its unique structure and potential applications. Here are some fascinating aspects worth noting:

  • Pharmacological Significance: This compound is notable for its potential as a pharmacological agent. Indoles are a prominent class of compounds in medicinal chemistry, often associated with various biological activities, such as anti-cancer and anti-inflammatory properties.
  • Structure-Activity Relationship: The presence of the piperazine moiety in its structure may enhance the compound’s interaction with specific receptors in the brain, making it a candidate for further investigations in neuropharmacology.
  • Indole Scaffolding: The indole core is known for its ability to mimic peptide structures, providing opportunities for developing novel therapeutic agents that may have fewer side effects than traditional drugs.
  • Synthetic Versatility: The various functional groups, such as the hydroxyl and carbonitrile groups, open pathways for further derivatization, enabling the creation of a library of analogs with potentially enhanced biological activities.
  • Potential Applications: Beyond its implications in pharmacology, this compound may have applications in fields such as materials science and organic electronics, where indole derivatives are being explored for their electronic properties.

In summary, 4-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxy-propoxy]-1H-indole-2-carbonitrile represents a remarkable intersection of organic synthesis, medicinal chemistry, and material science. As researchers delve deeper into its properties and potential applications, this compound may pave the way for innovative therapeutic approaches in the future.

Synonyms
97730-95-5
Dpi 201-106
DPI-201-106
4-[3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile
SDZ-201106
Racemic DPI 201-106
4-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy]-1H-indole-2-carbonitrile
CHEMBL314639
UI0EP1D878
97730-95-5 (racemic)
DPI 201-106;SDZ 201106
4-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy)-1H-indole-2-carbonitrile
4-[3-(4-Diphenylmethyl-1-piperazinyl)-2-hydroxypropoxy]-1H-indole-2-carbonitrile
(+/-)-SDZ-201106(DPI-201106)
CBiol_001886
4-{3-[4-(diphenylmethyl)piperazin-1-yl]-2-hydroxypropoxy}-1h-indole-2-carbonitrile
DPI-201106
4-(3-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-2-HYDROXYPROPOXY)-1H-INDOLE-2-CARBONITRILE
(+-)-4-(3-(4-(Diphenylmethyl)-1-piperazinyl)-2-hydroxypropoxy)-1H-indole-2-carbonitrile
UNII-UI0EP1D878
BSPBio_001475
KBioGR_000195
KBioSS_000195
dpi201-106
SCHEMBL2197158
KBio2_000195
KBio2_002763
KBio2_005331
KBio3_000389
KBio3_000390
DTXSID10913677
SDZ-201106 (+/-), (DPI-201106)
CHEBI:110175
Bio1_000172
Bio1_000661
Bio1_001150
Bio2_000195
Bio2_000675
HMS1361J17
HMS1791J17
HMS1989J17
HMS3402J17
EX-A8532
BDBM50001689
AKOS000278277
AKOS030548174
1H-Indole-2-carbonitrile, 4-(3-(4-(diphenylmethyl)-1-piperazinyl)-2-hydroxypropoxy-, (+-)-
IDI1_033945
NCGC00163143-01
NCGC00163143-02
NCGC00163143-03
DA-63015
DPI-201-106?
HY-19666
MS-28604
CS-0016178
Sdz-201106(+/-),(dpi-201106)
DPI-201-106, (+/-)-
BRD-A64553394-001-02-8
BRD-A64553394-001-04-4
Q27189556
4-[3-(4-Benzhydryl-piperazin-1-yl)-2-hydroxy-propoxy]-1H-indole-2-carbonitrile
1H-INDOLE-2-CARBONITRILE, 4-(3-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-2-HYDROXYPROPOXY)-