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Tenofovir disoproxil fumarate

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Identification
Molecular formula
C19H30N5O10P
CAS number
201341-05-1
IUPAC name
[[4-[[3-[(4-amino-3-fluoro-4-oxo-butyl)amino]-3-oxo-propyl]amino]-3-hydroxy-2,2-dimethyl-4-oxo-butoxy]-hydroxy-phosphoryl] [5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
State
State

At room temperature, Tenofovir disoproxil fumarate is typically in a solid state. As a pharmaceutically active ingredient, it is often stored and handled in its stable solid form to maintain efficacy before formulation into tablets or other dosage forms.

Melting point (Celsius)
114.50
Melting point (Kelvin)
387.65
Boiling point (Celsius)
222.10
Boiling point (Kelvin)
495.25
General information
Molecular weight
519.40g/mol
Molar mass
519.4030g/mol
Density
1.4000g/cm3
Appearence

Tenofovir disoproxil fumarate typically appears as a white to off-white crystalline powder. It is a stable compound under normal conditions and is only slightly soluble in water and soluble in methanol and slightly soluble in isopropanol.

Comment on solubility

Solubility of the Compound

The compound with the name [[4-[[3-[(4-amino-3-fluoro-4-oxo-butyl)amino]-3-oxo-propyl]amino]-3-hydroxy-2,2-dimethyl-4-oxo-butoxy]-hydroxy-phosphoryl] [5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate and the chemical formula C19H30N5O10P exhibits some unique solubility characteristics that are essential to its applications:

  • Water solubility: This compound is likely to be soluble in water due to the presence of multiple polar functional groups, particularly the phosphate groups, which tend to interact with water molecules.
  • Solubility in organic solvents: The solubility in organic solvents may vary, and it often depends on the overall hydrophobic and hydrophilic balance in the molecule. Compounds with large hydrophobic sections may show limited solubility in nonpolar solvents.
  • Influence of pH: The solubility might also be affected by the pH of the solution. Phosphate groups can ionize, leading to changes in solubility under varying pH conditions.
  • Temperature dependence: Like many compounds, solubility may increase with temperature, making it important to consider conditions during experimental procedures.
  • Crystallization tendencies: High molecular weight and complex structural features may lead to crystallization phenomena, which can affect the effective solubility during practical applications.

Overall, understanding the solubility of this compound is crucial for its effective use in chemical applications, particularly in biological systems where solubility can significantly influence bioactivity and transport mechanisms. Testing under various conditions is often recommended to fully characterize its solubility profile.

Interesting facts

Exploring a Complicated Compound

The compound named 4-[[3-[(4-amino-3-fluoro-4-oxo-butyl)amino]-3-oxo-propyl]amino]-3-hydroxy-2,2-dimethyl-4-oxo-butoxy]-hydroxy-phosphoryl] [5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate holds significant interest for scientists due to its intricate structure and potential biological applications. Here are some intriguing aspects of this compound:

  • Complex Pharmacophore: The compound showcases a complex pharmacophore that could interact with various biological targets, making it a candidate for drug discovery.
  • Fluoro-Modification: The presence of a fluorine atom is notable as it can enhance metabolic stability, thereby improving the compound's efficacy and bioavailability.
  • Phosphorylation: The phosphoryl group incorporated in its structure may confer essential characteristics for biological activity, particularly in medicinal chemistry.
  • Potential Applications: Its structural components suggest it could possess properties useful in treatments for conditions like cancer or bacterial infections, meriting further investigation.
  • Interdisciplinary Appeal: This compound represents an intersection of organic chemistry, medicinal chemistry, and biochemistry, appealing to a wide range of research fields.

"Understanding such complex molecules is vital for advancing pharmaceutical innovation." This compound exemplifies the intricate relationship between structure and function in drug development and highlights the importance of synthetic organic chemistry in creating novel therapeutic agents. As research progresses, compounds like this may pave the way for breakthroughs in targeted therapies and personalized medicine.