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Bupropion

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Identification
Molecular formula
C13H18ClNO
CAS number
31677-93-7
IUPAC name
4-(2,6-dimethyl-1-piperidyl)-1-phenyl-1-(2-pyridyl)butan-1-ol
State
State

At room temperature, Bupropion is a solid. It is stable under normal conditions and is often found in pharmaceutical formulations.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
425.00
Boiling point (Kelvin)
698.15
General information
Molecular weight
239.39g/mol
Molar mass
239.3890g/mol
Density
1.2130g/cm3
Appearence

Bupropion is an off-white, crystalline powder. It is usually provided in tablet form for medical use. The amphetamine-like structure gives it a distinctive look compared to other similar compounds.

Comment on solubility

Solubility of 4-(2,6-dimethyl-1-piperidyl)-1-phenyl-1-(2-pyridyl)butan-1-ol

The solubility of the compound 4-(2,6-dimethyl-1-piperidyl)-1-phenyl-1-(2-pyridyl)butan-1-ol (C13H18ClNO) can be influenced by several factors due to its complex structure. Here are some points to consider:

  • Polarity: The presence of the hydroxyl group (-OH) suggests the compound has some polar characteristics, which may enhance its solubility in polar solvents like water or alcohols.
  • Aliphatic and Aromatic Components: The combination of aliphatic chains and aromatic rings may contribute to a balance in solubility, where certain solvents may be more effective depending on the environment.
  • Temperature: Like many organic compounds, solubility is temperature-dependent; thus, increasing the temperature may lead to better solubility in various solvents.
  • pH Influence: The ionization state of the compound in different pH environments may also affect solubility, particularly due to the presence of functional groups that can either accept or donate protons.

In conclusion, while the solubility of this compound in water may be limited due to its large molecular size and the influence of hydrophobic interactions, it is expected to be more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO). Further studies and experimental determination may provide more definitive insights into its solubility profile.

Interesting facts

Interesting Facts about 4-(2,6-Dimethyl-1-piperidyl)-1-phenyl-1-(2-pyridyl)butan-1-ol

This compound, known for its complex structure, showcases a fascinating blend of several functional groups. It belongs to the class of drugs that exhibit interesting pharmacological activities. Here are some key highlights:

  • Diverse Functionality: The presence of both piperidine and pyridine rings in its structure indicates potential interactions with various biological receptors. These rings allow the compound to mimic natural substrates and participate in numerous biochemical processes.
  • Pharmaceutical Applications: Compounds like this often serve as precursors or lead compounds in drug design due to their ability to interact with neurotransmitter systems. They hold promise in developing new therapeutic agents for conditions such as anxiety and depression.
  • Synthetic Accessibility: The synthetic pathways to obtain this compound can be relatively straightforward, which allows for its easy modification. The introduction of different substituents could lead to compounds with enhanced biological activity.
  • Structure-Activity Relationship (SAR): Chemists are particularly interested in understanding how small changes to the molecular structure affect the pharmacological profile. This compound offers a rich platform for studying SAR due to its varied functional groups.

As a fascinating subject of study, 4-(2,6-dimethyl-1-piperidyl)-1-phenyl-1-(2-pyridyl)butan-1-ol illustrates the connection between chemical structure and biological function. Its exploration continues to reveal insights into drug design and development, making it a noteworthy topic in both academic and research settings.

Synonyms
(+/-)-Pirmenol
SCHEMBL220923
CHEMBL432103
DTXSID20860764
TCA25219
4-(2,6-dimethylpiperidin-1-yl)-1-phenyl-1-pyridin-2-ylbutan-1-ol
4-(2,6-dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol