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4-Hydroxyamphetamine

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Identification
Molecular formula
C9H13NO
CAS number
39542-60-4
IUPAC name
4-[2-(methylamino)propyl]phenol
State
State

The compound is typically a solid at room temperature.

Melting point (Celsius)
141.00
Melting point (Kelvin)
414.00
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.00
General information
Molecular weight
151.21g/mol
Molar mass
165.2300g/mol
Density
1.0450g/cm3
Appearence

4-Hydroxyamphetamine appears as a crystalline solid. It is typically encountered as a white or off-white powder.

Comment on solubility

Solubility of 4-[2-(methylamino)propyl]phenol (C9H13NO)

The solubility of 4-[2-(methylamino)propyl]phenol, a compound with the molecular formula C9H13NO, is influenced by several factors due to its unique structure. This compound features both a phenolic group and an amine functionality, making it relatively versatile in its solubility characteristics.

Factors Affecting Solubility:

  • Polarity: The presence of the hydroxyl group (–OH) allows for hydrogen bonding with water, enhancing its solubility in polar solvents.
  • Molecular Weight: With a molecular weight of 165.21 g/mol, lower molecular weight likely contributes to moderate solubility.
  • Alkyl Chain Length: The methylamino propyl side chain may introduce a degree of hydrophobic character, influencing the solubility in non-polar solvents.

As such, 4-[2-(methylamino)propyl]phenol is expected to exhibit:

  • Good solubility in water and other polar solvents due to polar interactions.
  • Limited solubility in non-polar solvents as a result of the phenolic group's hydrophilicity.

In practice, when considering solubility, it is essential to note that the environmental conditions, such as temperature and pH, can significantly impact these solubility characteristics. Therefore, it's best to conduct experiments to determine the precise solubility under specific conditions.

Interesting facts

Interesting Facts about 4-[2-(methylamino)propyl]phenol

4-[2-(methylamino)propyl]phenol, commonly referred to in scientific contexts due to its unique structure, has piqued the interest of chemists and researchers alike. Here are some engaging facts regarding this intriguing compound:

  • Structure and Functionality: The compound features a phenolic structure with a methylamino group, making it a part of a larger class of compounds known for their biological activity. The presence of the methylamino moiety enhances its potential interactions with biological targets.
  • Biological Relevance: Compounds like 4-[2-(methylamino)propyl]phenol are often studied for their implications in pharmacology. They can act as intermediates in the synthesis of more complex drugs and may exhibit properties that warrant further exploration in the fields of neurology and psychiatry.
  • Synthetic Pathways: The synthesis of this compound involves various organic reactions, illustrating the versatility of organic chemistry. The precise formation of such compounds is not only important for understanding their properties but also for developing new materials and medications.
  • Potential Applications: Due to its functional groups, this compound shows potential in various applications, such as:
    • Pharmaceuticals and drug development
    • Biochemical research
    • Potential use in the development of chemical sensors
  • Research Opportunities: The compound opens a pathway for intriguing research, especially in understanding its mechanism of action, efficacy, and safety profiles in biological systems.

In conclusion, 4-[2-(methylamino)propyl]phenol demonstrates a fascinating intersection between organic chemistry and applied biological science, reminding us that many small molecules hold great potential for impacting health and medicine.

Synonyms
Pholedrine
Pulsotyl
Veritol
370-14-9
Pressitan
P-HYDROXYMETHAMPHETAMINE
Foledrin
Isodrinum
Pholetone
Stimatone
Sympropamin
Syncordan
Terapinyl
Veritain
Epifen
Varitol
Knoll H75
4-[2-(Methylamino)propyl]phenol
Paredrinol
Promethin
Prometin
4-Hydroxymethamphetamine
4-(2-(Methylamino)propyl)phenol
N-Methylparedrine
Pholedrinum
4-Hydroxy-N-methylamphetamine
p-Hydroxy-N-methylbenzedrine
Racemic pholedrine
p-(2-Methylaminopropyl)phenol
Foledrinio
rac Pholedrine
Isodrin (sympathomimetic)
Oh-ma
Pholedrinum [INN-Latin]
Foledrinio [INN-Spanish]
1-(p-Hydroxyphenyl)-2-methylaminopropane
Pholedrine [INN:BAN:DCF]
(+/-)-Pholedrine
p-Hydroxy-N-methylamphetamine
Foledrina
p-Hydroxy-N,alpha-dimethylphenethylamine
beta-(p-Hydroxyphenyl)isopropylmethylamine
KNOLL-H75
Phenethylamine, p-hydroxy-N,alpha-dimethyl-
alpha-(p-Oxyphenyl)-beta-methyl aminopropane
PHENOL, p-(2-(METHYLAMINO)PROPYL)-
EINECS 206-725-0
AY28O44JGD
1-(p-Oxyphenyl)-2-methylaminopropan
Pholedrine (INN)
PHOLEDRINE [MI]
PHOLEDRINE [INN]
1-(p-Oxyphenyl)-2-methylaminopropan [German]
alpha-(p-Hydroxyphenyl)-beta-methylaminopropane
beta(p-Oxy-phenyl)isopropylmethylamin [German]
beta(p-Oxy-phenyl)isopropylmethylamin
Phenol, 4-(2-(methylamino)propyl)-
PHOLEDRINE [WHO-DD]
p-Hydroxy-N,.alpha.-dimethylphenethylamine
.beta.-(p-Hydroxyphenyl)isopropylmethylamine
(+/-)-1-(4-Hydroxyphenyl)-N-methyl-2-aminopropane
.alpha.-(p-Hydroxyphenyl)-.beta.-methylaminopropane
Phenol, 4-[2-(methylamino)propyl]-
Pholedrinum (INN-Latin)
Foledrinio (INN-Spanish)
Phenol, p-[2-(methylamino)propyl]-
rac Pholedrine (1.0mg/ml in Acetonitrile)
4-hydroxy-N-methylamphetamine; 4-HMA; rac Pholedrine
UNII-AY28O44JGD
Pholedrin
p-[2-(Methylamino)propyl]phenol
SCHEMBL119262
CHEMBL2008672
DTXSID70861908
p-[(2-Methylamino)propyl]phenol
CHEBI:134798
Isodrin (sympathomimetic compound)
p-[2-(methylamino)propyl]-phenol
p-Hydroxy-N,a-dimethylphenethylamine
AKOS005216720
AKOS017390993
FR27568
NCI60_042163
P-HYDROXYMETHAMPHETAMINE, (+/-)-
DB-049052
NS00007149
alpha-(p-hydroxyphenyl-beta-methylaminopropane
D08370
Phenethylamine, p-hydroxy-N,.alpha.-dimethyl-
p-Hydroxymethamphetamine, 1.0 mg/mL in methanol
.alpha.-(p-Oxyphenyl)-.beta.-methyl aminopropane
SR-01000944930
Q7187065
SR-01000944930-1
p-Hydroxymethamphetamine, analytical standard, for drug analysis
206-725-0
4-[2-(Methylamino)propyl]phenol;()-1-(4-Hydroxyphenyl)-N-methyl-2-aminopropane;(+/-))-Pholedrine