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piroxicam

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Identification
Molecular formula
C15H13N3O4
CAS number
36322-90-4
IUPAC name
4-[[2-benzamido-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid
State
State

At room temperature, piroxicam is typically found in a solid state. It is stable under normal conditions of use, storage, and handling. It is generally provided in tablet or capsule form for medicinal purposes.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
597.00
Boiling point (Kelvin)
870.15
General information
Molecular weight
331.35g/mol
Molar mass
331.3460g/mol
Density
1.6920g/cm3
Appearence

Piroxicam is a yellow solid compound. It typically exists as a powder with fine crystalline structure. Its appearance can vary slightly depending on the form, such as anhydrous or hydrate. When in its anhydrous form, it may appear more granulated or flaky.

Comment on solubility

Solubility of 4-[[2-benzamido-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid

The solubility of 4-[[2-benzamido-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid (C15H13N3O4) can be influenced by a variety of factors including temperature, pH, and the presence of solvents. Generally, this compound is expected to display moderate solubility characteristics due to the presence of both hydrophobic aromatic rings and hydrophilic functional groups.

Factors Influencing Solubility:

  • Temperature: Like many organic compounds, increased temperature may enhance solubility.
  • pH Levels: Given the presence of carboxylic acid groups, the solubility can shift dramatically under different pH conditions, as deprotonation may occur in alkaline conditions.
  • Solvent Type: The presence of polar solvents can facilitate solubility, whereas nonpolar solvents may not dissolve it effectively.

As noted, the structure contains multiple functional groups that can engage in hydrogen bonding, potentially leading to somewhat greater solubility in aqueous environments compared to purely hydrophobic compounds.
Thus, it is crucial to consider the solvent-sample interactions, making it essential to choose the right solvent for application purposes.

In summary, while this compound may not be highly soluble in all environments, the right conditions and solvents can enhance its solubility significantly, showcasing the intricate balance between structure and solubility behavior.

Interesting facts

Interesting Facts about 4-[[2-benzamido-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid

This fascinating compound, often referred to as a member of the amide family, boasts a range of intriguing properties and potential applications in the field of medicinal chemistry. Below are some notable aspects of this compound:

  • Pain Relief Potential: Compounds similar to this one are explored for their analgesic properties, making them candidates for pain management treatments.
  • Cancer Research: The structure of this compound reveals a potential influence on various cancer pathways, prompting studies into its efficacy as an anti-cancer agent.
  • Biochemical Applications: This compound's unique functional groups allow it to interact with specific proteins, leading to insights in biochemical research.
  • Structure-Activity Relationship: The complexity of this molecule allows chemists to study how minor modifications can significantly change its biological activity.
  • Pharmaceutical Benefits: The amide bond and aromatic rings present in this compound are essential components in the design of pharmaceuticals, highlighting its importance in drug development.

As noted by researchers, "The intersection of structure and function in complex molecules like this one provides a rich landscape for discovery."
Understanding the properties of compounds like 4-[[2-benzamido-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid not only advances scientific knowledge but also opens doors to innovative therapeutics that could improve health outcomes.

Synonyms
N-benzoyl-l-tyrosyl-paba
PFT
PFD (TN)
Bentiromide (JAN/USAN/INN)
SCHEMBL1001794
(S)-4-([2-(Benzoylamino)-3-(4-hydroxyphenyl)propanoyl]amino)benzoic acid
CHEMBL4793122
DTXSID80860543
4-[(N-Benzoyltyrosyl)amino]benzoic acid
NS00004079
N-(N-Benzoyl-L-tyrosyl)-4-aminobenzoic Acid
D01346
G12135