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4'-Fluoro-α-pyrrolidinobutiophenone

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Identification
Molecular formula
C15H20FNO
CAS number
849231-08-9
IUPAC name
4-(2-azaspiro[4.4]nonan-2-yl)-1-(4-fluorophenyl)butan-1-one
State
State

At room temperature, the compound is in a solid state. It is commonly handled in laboratories and may require appropriate storage conditions to maintain its stability.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
340.00
Boiling point (Kelvin)
613.15
General information
Molecular weight
263.34g/mol
Molar mass
263.3350g/mol
Density
1.1700g/cm3
Appearence

It is typically encountered as a white crystalline solid. The exact appearance can vary slightly, but the general aspect of a crystalline solid remains consistent.

Comment on solubility

Solubility of 4-(2-azaspiro[4.4]nonan-2-yl)-1-(4-fluorophenyl)butan-1-one

The compound 4-(2-azaspiro[4.4]nonan-2-yl)-1-(4-fluorophenyl)butan-1-one, with the chemical formula C15H20FNO, exhibits intriguing solubility characteristics that can impact its application and utility in various fields.

Solubility Profile

Examining its solubility, we can outline the following key points:

  • Polar vs. Nonpolar: The presence of the amino group (N) and fluorine (F) may impart some polar characteristics to the molecule, suggesting that it could be more soluble in polar solvents compared to nonpolar solvents.
  • Solvent Compatibility: It is likely to be soluble in polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), while exhibiting limited solubility in hydrocarbons like hexane or toluene.
  • Temperature Dependence: Like many organic compounds, solubility might increase with temperature, a common trait allowing for greater dissolution at elevated conditions.
  • Functional Group Influence: The unique spiro structure can affect intermolecular interactions, potentially altering solubility through hydrogen bonding or dipole-dipole interactions.

In summary, while specific solubility values for this compound can vary with experimental conditions, its structural features suggest enhanced solubility in polar solvents and moderate solubility in less polar environments. This characteristic makes it a subject of interest for further exploration in both chemical synthesis and practical applications.

Interesting facts

Interesting Facts about 4-(2-azaspiro[4.4]nonan-2-yl)-1-(4-fluorophenyl)butan-1-one

4-(2-azaspiro[4.4]nonan-2-yl)-1-(4-fluorophenyl)butan-1-one is a fascinating compound that has garnered attention in various fields, particularly in medicinal chemistry and drug design. Here are some intriguing aspects of this compound:

  • Potential Therapeutic Applications: This compound has shown promise as a building block for developing drugs, specifically in treating neurological disorders. Its structure suggests that it may interact effectively with specific receptors in the brain.
  • Structural Complexity: The inclusion of a spirocyclic structure in its molecular framework gives it unique conformational characteristics. Such structures can result in compounds with enhanced biological activity due to their ability to fit into specific biological targets.
  • Fluorine's Role: The presence of the fluorine atom in the phenyl group enhances both the lipophilicity and metabolic stability of the compound, which can lead to improved pharmacokinetic properties.
  • Innovative Synthesis: The synthesis of this compound involves complex multi-step reactions that highlight the creativity and skill required in organic chemistry. It serves as an excellent example of how diverse functional groups can be integrated into a single molecular entity.
  • Research Applications: Due to its interesting properties, this compound is often utilized in research to study structure-activity relationships (SAR) in drug discovery, allowing scientists to design new and potentially more effective therapeutic agents.

As with many compounds in the field of medicinal chemistry, the study of 4-(2-azaspiro[4.4]nonan-2-yl)-1-(4-fluorophenyl)butan-1-one continues to unveil new possibilities and applications, making it a subject of ongoing research and exploration. Intriguingly, as scientific knowledge progresses, compounds like this one could potentially lead to breakthroughs in treatments for various diseases.

Synonyms
BRN 1430287
64-63-1
BUTYROPHENONE, 4-(2-AZASPIRO(4.4)NON-2-YL)-4'-FLUORO-
4-(2-Azaspiro(4.4)non-2-yl)-4'-fluoro-butyrophenone
DTXSID80213979
5-20-04-00355 (Beilstein Handbook Reference)
1-(4-Fluorophenyl)-4-(2-azaspiro[4.4]nonan-2-yl)butan-1-one
DTXCID60136470