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Tenofovir disoproxil fumarate

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Identification
Molecular formula
C19H30N5O10P
CAS number
147127-20-6
IUPAC name
[4-(2-amino-6-oxo-3H-purin-9-yl)-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl phosphono hydrogen phosphate
State
State

At room temperature, this compound is typically in a solid state. As a pharmaceutical compound, it may be formulated in various forms for drug delivery.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
519.45g/mol
Molar mass
519.4480g/mol
Density
1.4950g/cm3
Appearence

Tenofovir disoproxil fumarate typically appears as a white to off-white crystalline powder. It is usually odorless with high solubility in water and various solvents.

Comment on solubility

Solubility of [4-(2-amino-6-oxo-3H-purin-9-yl)-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl phosphono hydrogen phosphate

The solubility of the compound C19H30N5O10P can be attributed to its structural features, which include both polar and non-polar interactions. Understanding this aspect is crucial for applications in various fields including pharmaceuticals and biochemistry.

Factors Influencing Solubility:

  • Polarity: The presence of multiple oxygen (O) and nitrogen (N) atoms generally enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds with water molecules plays a critical role in solubility.
  • Molecular Size: Larger molecular size can sometimes reduce solubility due to steric hindrance, impacting how well the compound dissolves.
  • pH Sensitivity: The solubility might also vary with pH due to the ionization of functional groups within the molecule.

In many cases, compounds similar to this one exhibit the following solubility characteristics:

  1. Moderate to High Solubility: Commonly soluble in aqueous solutions due to polar groups.
  2. Solvent Specific: May show differential solubility in organic solvents compared to water.
  3. Influence of Temperature: Higher temperatures often increase solubility for many compounds.

In conclusion, the solubility of [4-(2-amino-6-oxo-3H-purin-9-yl)-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl phosphono hydrogen phosphate is likely to be influenced by its molecular structure, functional groups, and the solvent used. As a result, experimental determination is essential for precise applications.

Interesting facts

Interesting Facts about [4-(2-amino-6-oxo-3H-purin-9-yl)-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl phosphono hydrogen phosphate

This intriguing compound is a complex molecule that showcases the beauty of chemical diversity, particularly in the realm of biochemistry. Here are some fascinating facts about it:

  • Nucleobase Component: The presence of a purine structure highlights its potential relationship with biological molecules such as DNA and RNA, making it a compound of interest in genetic studies.
  • Phosphorylation: The inclusion of phosphoryl groups suggests a role in energy transfer or signaling pathways in biological systems.
  • Potential Applications: Researchers may explore its use in medicinal chemistry, particularly in the development of targeted therapies for diseases related to nucleic acid metabolism.
  • Structural Complexity: With multiple functional groups and a sophisticated stereochemistry, studying this compound can lead to new insights in organic synthesis and product design.
  • Potential for Antiviral Activity: Compounds that contain purine derivatives are often investigated for their antiviral properties, thus this molecule might spark further research in that area.

As chemists continue to delve into the structural intricacies of such compounds, the implications for both basic science and applied chemistry grow significantly. In the words of esteemed chemist Richard Feynman, "What I cannot create, I do not understand." Understanding and synthesizing this compound could illuminate various biochemical processes.

The integration of organic and inorganic frameworks observed in this compound not only exemplifies the interconnectedness of chemical disciplines but also serves as a reminder of the elegance of molecular architecture. Each component, when pieced together, has the potential to unlock new realms of chemical knowledge and practical applications.