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Abacavir

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Identification
Molecular formula
C14H18N6O
CAS number
136470-78-5
IUPAC name
[4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol
State
State

At room temperature, Abacavir is in a solid state, appearing as a powdery substance.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
600.00
Boiling point (Kelvin)
873.15
General information
Molecular weight
286.34g/mol
Molar mass
286.3350g/mol
Density
1.4900g/cm3
Appearence

Abacavir is typically a white to off-white solid powder. It is generally crystalline in nature when viewed closely.

Comment on solubility

Solubility of [4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol

The solubility of the compound [4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol (C14H18N6O) can be described through several important factors:

  • Polarity: The presence of the hydroxyl (-OH) group in the methanol portion contributes to its overall polarity, which generally enhances solubility in polar solvents like water.
  • Hydrogen Bonding: The compound's ability to form hydrogen bonds can improve its solubility in polar environments, making it more soluble in solvents that can engage in hydrogen bonding.
  • Hydrophobic and Hydrophilic Regions: The structure features both hydrophobic cyclopropyl and hydrophilic amine and hydroxyl parts, indicating a complex interaction with solvents of varying polarity.
  • Effect of pH: As an amino compound, its solubility may also be influenced by the pH of the solution; at different pH levels, the amino groups can become protonated or deprotonated, affecting solubility.

In summary, while the exact quantitative solubility of this specific compound remains to be elucidated through experimental data, it can be inferred that its solubility characteristics will significantly depend on the interactions of various functional groups within its structure. As noted, the complex interplay between hydrophobic and hydrophilic segments plays a critical role, making its solubility intriguing and worthy of further consideration.

Interesting facts

Discovering 4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol

This intriguing compound encompasses a unique combination of structural features that piques the interest of chemists and biologists alike. One notable aspect is its relationship to purine structures, which are fundamental components of nucleic acids like DNA and RNA. The presence of the cyclopropylamino group introduces a fascinating twist, as cyclopropyl groups are known for their distinct strain and have been implicated in various biological activities.

Key Points about the Compound:

  • Biological Implications: Its structural characteristics suggest potential roles in medicinal chemistry, especially concerning nucleobase analogs that could influence cellular processes.
  • Structural Complexity: The cyclopent-2-en-1-yl component heightens the molecular complexity, which may lead to novel interactions in biological systems.
  • Research Potential: This compound could serve as an essential tool in studying enzyme mechanisms or drug development due to its purine-like behavior.

One of the fascinating aspects of exploring this compound lies in understanding how subtle modifications to molecular structures can lead to profound changes in biological function. As chemists delve into the properties of 4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol, the potential for discovering novel applications in therapeutic medicine becomes ever more enticing.

In the words of famous chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound is a testament to the endless possibilities that arise from creative chemical structuring!

Synonyms
914348-29-1
{4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
(4-(2-Amino-6-(cyclopropylamino)-9h-purin-9-yl)cyclopent-2-en-1-yl)methanol
NSC742406
SCHEMBL464832
CHEMBL300576
DTXSID20861337
STL504711
AKOS037487916
2-Cyclopentene-1-methanol, (1S,4R)-
DB-042342
CS-0355065
EN300-297718
SR-01000942218
SR-01000942218-3
4-[2-amino-6-(cyclopropylamino)-9h-purin-9-yl]-2-cyclopentene-1-methanol