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Simvastatin

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Identification
Molecular formula
C25H38N2O5
CAS number
79902-63-9
IUPAC name
4-[2-[[4-[[2-[(2-acetamido-3-methyl-butanoyl)amino]-3-methyl-butanoyl]amino]-3-hydroxy-6-methyl-heptanoyl]amino]propanoylamino]-3-hydroxy-6-methyl-heptanoic acid
State
State

Simvastatin is a solid at room temperature, typically found in the form of tablets. It is used as a lipid-lowering medication to control elevated cholesterol levels.

Melting point (Celsius)
138.00
Melting point (Kelvin)
411.15
Boiling point (Celsius)
487.00
Boiling point (Kelvin)
760.15
General information
Molecular weight
418.57g/mol
Molar mass
418.5710g/mol
Density
1.0460g/cm3
Appearence

Simvastatin appears as a white to off-white crystalline powder. It is practically insoluble in water and freely soluble in chloroform, methanol, and ethanol. The compound usually comes in the form of tablets when prepared for pharmaceutical use.

Comment on solubility

Solubility of 4-[2-[[4-[[2-[(2-acetamido-3-methyl-butanoyl)amino]-3-methyl-butanoyl]amino]-3-hydroxy-6-methyl-heptanoyl]amino]propanoylamino]-3-hydroxy-6-methyl-heptanoic acid

This compound, with the chemical formula C25H38N2O5, presents a unique case in terms of solubility due to its complex structure and multiple functional groups. Here are some key considerations regarding its solubility:

  • Hydrophobic vs. Hydrophilic Characteristics: With a relatively large organic backbone, the compound contains both hydrophobic (from the long carbon chains) and hydrophilic (from the amide and hydroxyl groups) regions.
  • Solvent Dependency: The solubility of this compound may vary significantly depending on the solvent used. It is likely to exhibit higher solubility in polar solvents (such as water or methanol) due to the presence of hydroxyl and amide groups.
  • Temperature Effects: Like many compounds, solubility can increase with temperature. A higher temperature may provide more kinetic energy, helping to overcome intermolecular forces.
  • pH Influence: The solubility could also be affected by the pH of the solution, particularly if the compound can exist in ionized (charged) forms. This is particularly pertinent for acids and bases.

In conclusion, while the specific solubility values of this compound might not be readily available, it is a prime candidate for study in various solvents, and the intricate balance of its functional groups plays a crucial role in determining its overall solubility behavior. As always, experimental data should be sought to obtain precise solubility metrics.

Interesting facts

Interesting Facts about 4-[2-[[4-[[2-[(2-acetamido-3-methyl-butanoyl)amino]-3-methyl-butanoyl]amino]-3-hydroxy-6-methyl-heptanoyl]amino]propanoylamino]-3-hydroxy-6-methyl-heptanoic acid

This compound represents a fascinating and complex structure that showcases the beauty of organic chemistry. Often encountered in biochemistry and pharmaceuticals, its intricate design is indicative of the interactions and functions that can arise in biological systems.

Key Features of the Compound:

  • Multi-functional Role: The presence of multiple amino groups allows this compound to engage in a variety of biological interactions, potentially serving as a building block for peptides or proteins.
  • Structure Activity Relationship: The unique arrangement and modification of amino groups and hydroxyl groups suggest that even slight changes to the structure could lead to significant variations in biological activity.
  • Potential Therapeutic Applications: Due to its complex nature and ability to interact with various biological receptors, this compound may hold promise for drug development, particularly in the field of targeted therapies.

Moreover, the compound's intermediates derived from its structure could be valuable in synthetic chemistry. While we often want to simplify our understanding of compounds, this particular molecule reminds us of the fascinating complexity inherent in biochemical processes. As stated by renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This sentiment rings true here, as each functional group and modification opens new pathways for exploration.

In conclusion, 4-[2-[[4-[[2-[(2-acetamido-3-methyl-butanoyl)amino]-3-methyl-butanoyl]amino]-3-hydroxy-6-methyl-heptanoyl]amino]propanoylamino]-3-hydroxy-6-methyl-heptanoic acid serves as a striking example of the intricate relationships within organic chemistry. It is essential for students and scientists alike to delve into such compounds, as they pave the way for innovation in medicinal chemistry and biochemistry.

Synonyms
Pepstatin A (acetate)
Pepstatin acetate
G85503