Skip to main content

Thiamine pyrophosphate

ADVERTISEMENT
Identification
Molecular formula
C12H19N4O7P2
CAS number
154-87-0
IUPAC name
4-[[2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-4-hydroxy-butanoic acid
State
State

In its solid form, thiamine pyrophosphate is a crystalline powder at room temperature. However, it is highly soluble in water, which facilitates its use in aqueous biological systems.

Melting point (Celsius)
60.00
Melting point (Kelvin)
333.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
466.35g/mol
Molar mass
466.3540g/mol
Density
1.4199g/cm3
Appearence

Thiamine pyrophosphate appears as a white to off-white crystalline powder. It is typically stable under standard temperature and pressure but should be protected from light and moisture to prevent degradation. The compound is highly soluble in water, resulting in clear solutions.

Comment on solubility

Solubility of 4-[[2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-4-hydroxy-butanoic acid (C12H19N4O7P2)

The solubility of this complex compound can be quite intriguing given its multifaceted structure, which comprises various functional groups that significantly affect its interaction with solvents. Here are some key considerations regarding its solubility:

  • Polarity: The presence of multiple hydroxyl (-OH) and phosphoryl (-PO4) groups suggests that this compound may exhibit high polarity, enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to its hydroxyl groups can lead to improved solubility in aqueous environments, as these hydrogen bonds can stabilize interactions with water molecules.
  • Ionization: The acidic nature of butanoic acid may allow for ionization in aqueous solutions, potentially resulting in increased solubility. It is likely to dissociate in water, contributing to its overall solubility when considering the pH of the solution.
  • Solvent Interaction: While this compound is likely soluble in polar solvents, it may face challenges in non-polar solvents due to its structural features. The steric hindrance introduced by the thiazolium and pyrimidinyl rings may further complicate interactions with non-polar media.

In conclusion, the solubility of C12H19N4O7P2 is expected to be significantly better in polar solvents because of its polar functional groups, hydrogen bonding capability, and potential for ionization. However, studying specific solubility conditions and solvent systems will provide more definitive insights.

Interesting facts

Exploring the Unique Compound: 4-[[2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-4-hydroxy-butanoic acid

This intriguing compound is a prime example of the complex nature of modern pharmaceuticals and biochemical research. As a derivative featuring nitrogen, phosphorus, and sulfur-containing moieties, it highlights the advances in medicinal chemistry aimed at developing effective therapeutics.

Key Features:

  • Diverse Functional Groups: The molecule incorporates various functional groups, including amino groups, hydroxyl groups, and thiazolium, which play essential roles in biological activity and interaction with biological macromolecules.
  • Pyrimidine Backbone: The inclusion of a pyrimidine ring, known for its role in nucleosides and nucleotides, showcases the compound's potential in molecular biology and genetic research.
  • Phosphoryl Moieties: The presence of phosphorus in the form of phosphoryl groups suggests potential applications in phosphorylation processes, critical in signaling pathways within cells.
  • Antimicrobial and Antitumor Potential: Compounds resembling this structure have been studied for their antimicrobial and antitumor properties, making them of interest in drug development.

Applications and Impacts:

Scientists are continuously exploring the multifaceted applications of compounds like this one, including:

  • Designing targeted therapies to combat resistant strains of bacteria or cancer cells.
  • Enhancing gene therapy strategies by utilizing nucleobase analogs that can interfere with nucleic acid synthesis.
  • Investigation in the realm of bioconjugation techniques, merging biological molecules with nanoparticles for improved drug delivery systems.

In closing, the intricate design of this compound serves as a reminder of the rich tapestry of chemical research that continually unveils the potential of new materials. Each layer of its structure opens opportunities for discovery that could lead to novel therapeutics, better understanding of biological processes, and advancements in medical science.