Skip to main content

Adefovir dipivoxil

ADVERTISEMENT
Identification
Molecular formula
C20H32N5O8P
CAS number
142340-99-6
IUPAC name
4-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylamino]-4-oxo-butanoic acid
State
State

At room temperature, Adefovir dipivoxil is a solid.

Melting point (Celsius)
97.00
Melting point (Kelvin)
370.15
Boiling point (Celsius)
205.00
Boiling point (Kelvin)
478.15
General information
Molecular weight
501.48g/mol
Molar mass
501.4760g/mol
Density
1.5600g/cm3
Appearence

Adefovir dipivoxil is a white to off-white crystalline powder. It is generally hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 4-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylamino]-4-oxo-butanoic acid

The solubility of a compound is a crucial property that influences its bioavailability and functionality in various applications. For the complex compound 4-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylamino]-4-oxo-butanoic acid (C20H32N5O8P), we find interesting considerations:

  • Water Solubility: Generally, compounds that contain multiple hydroxyl (–OH) groups and phosphonate (-PO3) moieties are expected to have higher solubility in water due to their ability to form hydrogen bonds.
  • Organic Solvents: Solubility in organic solvents may vary; compounds with a high degree of polarity, like this one, can exhibit limited solubility in non-polar solvents.
  • pH Sensitivity: The solubility can also be influenced by pH, especially if the compound contains acidic groups. An increase in pH may lead to deprotonation of carboxylic acids, enhancing solubility.
  • Thermal Stability: Solubility can be affected by temperature; some compounds become more soluble when heated.

In summary, the solubility of this compound is likely influenced by a combination of its structural features and environmental conditions. The presence of hydrophilic groups lends it a potential for good solubility in aqueous environments, which is pivotal for its probable applications in biological systems.

Interesting facts

Exploring the Complexities of a Unique Chemical Compound

This fascinating compound, known as 4-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylamino]-4-oxo-butanoic acid, is a remarkable example of the complexity found within chemical structures in the field of biochemistry. Here are some intriguing facts about this compound:

  • Biological Significance: This compound features a unique arrangement of amino acids and phosphonic acid derivatives which suggests potential roles in biological systems, particularly in relation to cellular signaling and metabolism.
  • Phosphorylation: The presence of multiple phosphono groups highlights its potential as a biologically active phosphoramidate, possibly impacting interactions with biomolecules like proteins and nucleic acids.
  • Structure-Activity Relationship: The complexity of its structure makes it an interesting candidate for studies on structure-activity relationships (SAR), where scientists might investigate how changes to its molecular design could influence its biological activity.
  • Source of Inspiration: Researchers often find that understanding such complex compounds can lead to discoveries regarding drug development and therapeutic interventions, particularly in targeting specific enzymes or pathways.
  • Potential Applications: Given its intricate structure, this compound may have implications in pharmaceuticals, specifically in the treatment of diseases influenced by purine metabolism.

As we delve deeper into the realm of chemical compounds, it becomes clear that structural diversity is essential to the development of innovative solutions in medicinal chemistry. This particular compound is a testament to the extraordinary complexity found in nature and the potential applications that can arise from its study.