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Hydrocortisone acetate

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Identification
Molecular formula
C23H32O6
CAS number
50-03-3
IUPAC name
4-[2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid
State
State

At room temperature, hydrocortisone acetate is typically in a solid state, appearing as a fine crystalline powder. It is stable under normal conditions of use and storage.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
462.80
Boiling point (Kelvin)
735.95
General information
Molecular weight
404.50g/mol
Molar mass
404.4980g/mol
Density
1.3100g/cm3
Appearence

Hydrocortisone acetate appears as a white to practically white crystalline powder. It may appear slightly off-white due to impurities, but in its purest form, it maintains a bright white hue.

Comment on solubility

Solubility of 4-[2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid (C23H32O6)

The solubility of 4-[2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid is influenced by several factors including the compound's structural components and the nature of its functional groups. Solubility can be categorized based on the following considerations:

  • Polarity: The presence of hydroxyl groups (–OH) typically increases solubility in polar solvents such as water. This compound contains two hydroxyl groups which may enhance its solubility in such solvents.
  • Hydrophobic Character: The extensive hydrocarbon framework suggests a certain degree of hydrophobicity, potentially limiting solubility in aqueous environments.
  • Solvent Compatibility: Solubility may vary significantly with different solvents. Organic solvents, such as ethanol or methanol, may be more effective in dissolving this compound than water.
  • Functional Group Interactions: The ketone (–C=O) and carboxylic acid (–COOH) functional groups contribute to possible hydrogen bonding, influencing interaction with solvent molecules.

In summary, while the presence of hydroxyl and carboxylic acid functional groups suggests that 4-[2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid may exhibit some degree of solubility in polar solvents, it is essential to consider its hydrophobic nature and the influence of the solvent used.

Interesting facts

Interesting Facts about 4-[2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid

This compound represents a fascinating class of organic molecules that display significant biochemical activities. Here are some intriguing aspects of this compound:

  • Complex Structure: The molecule features a unique architecture with multiple functional groups that enhance its reactivity. Its complexity includes multiple hydroxyl groups and a distinctive cyclopentaphenanthrene core, which is often found in natural steroids.
  • Biological Significance: Compounds similar to this one are often studied for their potential therapeutic effects. They may exhibit properties such as anti-inflammatory, anti-cancer, or antioxidant activities. Research into such molecules often delves into their interactions with biological systems.
  • Synthesis Challenges: The synthesis of this compound is likely to require careful planning and multi-step processes. The presence of various stereocenters can make it challenging to achieve the desired configuration without significant effort.
  • Natural Occurrence: The cornerstone structure may resemble naturally occurring steroids, which are vital in many biological processes, such as hormonal regulation and cell membrane fluidity. Studying these compounds enhances our understanding of steroid chemistry.
  • Potential Applications: Given its structural features, the compound could be a candidate for drug development, particularly in areas targeting hormonal diseases or metabolic disorders.

The study of such complex compounds not only enriches the field of organic chemistry but also contributes to the broader scientific understanding of medicinal chemistry and drug design. **As a quote often reiterated in the chemistry community**: "Every molecule tells a story, and some stories are worth exploring deeply."

Synonyms
DTXSID10859723
NS00009851
4-[(11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl)oxy]-4-oxobutanoic acid