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Betamethasone 21-acetate

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Identification
Molecular formula
C24H31FO6
CAS number
987-24-6
IUPAC name
4-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid
State
State

At room temperature, Betamethasone 21-acetate exists as a solid. Its crystalline form makes it stable under standard conditions, and it is usually stored in a dry environment to prevent degradation.

Melting point (Celsius)
211.15
Melting point (Kelvin)
484.30
Boiling point (Celsius)
273.15
Boiling point (Kelvin)
546.30
General information
Molecular weight
476.54g/mol
Molar mass
476.5400g/mol
Density
1.3000g/cm3
Appearence

Betamethasone 21-acetate is typically a white or almost white crystalline powder. It is characterized by its lack of significant odor and a smooth texture.

Comment on solubility

Solubility of 4-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid

The solubility of the compound with the chemical formula C24H31FO6 is a critical aspect to consider for its potential applications. Since this compound contains multiple functional groups, its solubility is influenced by several factors.

Factors Affecting Solubility

  • Polarity: The presence of hydroxyl groups (–OH) generally enhances solubility in polar solvents like water.
  • Hydrophobic Regions: The large hydrophobic segments of the molecule may lead to limited solubility in water.
  • Solvation: Ability of solvents to solvate the compound will greatly affect solubility; for instance, organic solvents may dissolve the compound better than water.

In many cases, compounds similar to this one exhibit variable solubility in:

  • Water - Often limited due to hydrophobic characteristics.
  • Alcohols - May show better solubility, particularly in ethanol or methanol.
  • Aqueous Solutions - Potential for solubility enhancement with appropriate pH adjustments.

As such, it would be prudent to conduct empirical tests to accurately determine the solubility characteristics in various solvents. Such tests are essential for understanding how this compound can be effectively utilized in pharmaceutical or biochemical contexts.

Interesting facts

Interesting Facts about 4-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid

This intriguing compound belongs to a class of substances known as steroids, which are essential in various biological processes. Steroids often function as hormones, influencing metabolism, immune function, and salt balance in the body.

Key Characteristics

  • Functional Groups: The presence of multiple hydroxyl groups suggests potential solubility and biological activity, making this compound of interest in pharmacological studies.
  • Biological Significance: Compounds similar to this one may exhibit significant pharmacological effects, particularly in hormone regulation.
  • Synthetic Pathways: Understanding the synthesis of this compound can provide insights into developing new therapeutic agents.

A Few Interesting Insights

Here are some captivating aspects of this compound:

  • Structural Complexity: The structure features multiple rings and stereocenters, posing interesting challenges and opportunities for synthetic chemistry.
  • Biochemical Pathways: The compound may interact with specific enzymatic pathways, impacting areas such as steroidogenesis.
  • Potential Applications: It could serve as a lead compound in drug discovery aimed at treating hormonal imbalances or other related disorders.

Overall, 4-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid represents a fascinating area of study within the realm of organic and medicinal chemistry, showcasing the intricate interplay between structure and biological activity.

Synonyms
prednisolone succinate
4-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy]-4-oxobutanoic acid
NCGC00183124-01
SCHEMBL13026153
DTXSID80859674
BCP34113
DB-047541
F85234
Prednisolone Impurity 4;Prednisolone 21-hemisuccinate